FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296236224> ?p ?o ?g. }

• W4296236224 abstract "Abstract Gene expression profiling (GEP) is considered as gold standard for cell-of-origin (COO) classification of diffuse large B-cell lymphoma (DLBCL). However, the high dimensionality of GEP limits its application in clinical practice. In this study, we aim to develop a parsimonious model based on GEP to accurately predict COO subtype of DLBCL for clinical applications. We first proposed a variable important measure to solve the instability of penalized regression methods in high-dimensional settings. Then this strategy was applied to six penalized methods to identify a small gene subset for DLBCL classification. Using a training dataset of 350 DLBCL patients, we developed a six-gene model for DLBCL classification. For training and validation datasets, model evaluations showed the six-gene model performed well in terms of discrimination, calibration and clinical usefulness. Subgroups of patients characterized by these six genes showed significantly different prognosis. Furthermore, model comparisons demonstrated that the six-gene model outperformed models constructed by typical penalized regression methods. In conclusion, the six genes had considerable clinical usefulness in DLBCL classification and prognosis. The genes order based on their importance provided a priority for further functional and targeted drug research." @default.
• W4296236224 created "2022-09-18" @default.
• W4296236224 creator A5000293968 @default.
• W4296236224 creator A5000528066 @default.
• W4296236224 creator A5017841304 @default.
• W4296236224 creator A5034532201 @default.
• W4296236224 creator A5058314921 @default.
• W4296236224 creator A5071972213 @default.
• W4296236224 creator A5073524724 @default.
• W4296236224 date "2022-09-09" @default.
• W4296236224 modified "2023-10-14" @default.
• W4296236224 title "Subtype classification and prognosis of diffuse large B-cell lymphoma based on variable importance analysis" @default.
• W4296236224 cites W1782183425 @default.
• W4296236224 cites W1853055195 @default.
• W4296236224 cites W1969132581 @default.
• W4296236224 cites W1976564639 @default.
• W4296236224 cites W1998513750 @default.
• W4296236224 cites W2004831407 @default.
• W4296236224 cites W2020925091 @default.
• W4296236224 cites W2023187622 @default.
• W4296236224 cites W2024990640 @default.
• W4296236224 cites W2028477010 @default.
• W4296236224 cites W2029341502 @default.
• W4296236224 cites W2043316586 @default.
• W4296236224 cites W2068343048 @default.
• W4296236224 cites W2070872496 @default.
• W4296236224 cites W2074682976 @default.
• W4296236224 cites W2076236096 @default.
• W4296236224 cites W2090233475 @default.
• W4296236224 cites W2107665951 @default.
• W4296236224 cites W2116420885 @default.
• W4296236224 cites W2119910794 @default.
• W4296236224 cites W2133878894 @default.
• W4296236224 cites W2136392251 @default.
• W4296236224 cites W2139954541 @default.
• W4296236224 cites W2147246240 @default.
• W4296236224 cites W2158631566 @default.
• W4296236224 cites W2167536907 @default.
• W4296236224 cites W2171448541 @default.
• W4296236224 cites W2184467029 @default.
• W4296236224 cites W2225121000 @default.
• W4296236224 cites W2296718190 @default.
• W4296236224 cites W2324751340 @default.
• W4296236224 cites W2417116130 @default.
• W4296236224 cites W2462540433 @default.
• W4296236224 cites W3106108064 @default.
• W4296236224 cites W4234698323 @default.
• W4296236224 cites W4236710883 @default.
• W4296236224 cites W1969998568 @default.
• W4296236224 doi "https://doi.org/10.21203/rs.3.rs-27723/v2" @default.
• W4296236224 hasPublicationYear "2022" @default.
• W4296236224 type Work @default.
• W4296236224 citedByCount "0" @default.
• W4296236224 crossrefType "posted-content" @default.
• W4296236224 hasAuthorship W4296236224A5000293968 @default.
• W4296236224 hasAuthorship W4296236224A5000528066 @default.
• W4296236224 hasAuthorship W4296236224A5017841304 @default.
• W4296236224 hasAuthorship W4296236224A5034532201 @default.
• W4296236224 hasAuthorship W4296236224A5058314921 @default.
• W4296236224 hasAuthorship W4296236224A5071972213 @default.
• W4296236224 hasAuthorship W4296236224A5073524724 @default.
• W4296236224 hasBestOaLocation W42962362241 @default.
• W4296236224 hasConcept C105795698 @default.
• W4296236224 hasConcept C126322002 @default.
• W4296236224 hasConcept C143998085 @default.
• W4296236224 hasConcept C154945302 @default.
• W4296236224 hasConcept C2778559949 @default.
• W4296236224 hasConcept C2779338263 @default.
• W4296236224 hasConcept C33923547 @default.
• W4296236224 hasConcept C41008148 @default.
• W4296236224 hasConcept C70721500 @default.
• W4296236224 hasConcept C71924100 @default.
• W4296236224 hasConcept C83546350 @default.
• W4296236224 hasConcept C86803240 @default.
• W4296236224 hasConceptScore W4296236224C105795698 @default.
• W4296236224 hasConceptScore W4296236224C126322002 @default.
• W4296236224 hasConceptScore W4296236224C143998085 @default.
• W4296236224 hasConceptScore W4296236224C154945302 @default.
• W4296236224 hasConceptScore W4296236224C2778559949 @default.
• W4296236224 hasConceptScore W4296236224C2779338263 @default.
• W4296236224 hasConceptScore W4296236224C33923547 @default.
• W4296236224 hasConceptScore W4296236224C41008148 @default.
• W4296236224 hasConceptScore W4296236224C70721500 @default.
• W4296236224 hasConceptScore W4296236224C71924100 @default.
• W4296236224 hasConceptScore W4296236224C83546350 @default.
• W4296236224 hasConceptScore W4296236224C86803240 @default.
• W4296236224 hasLocation W42962362241 @default.
• W4296236224 hasLocation W42962362242 @default.
• W4296236224 hasOpenAccess W4296236224 @default.
• W4296236224 hasPrimaryLocation W42962362241 @default.
• W4296236224 hasRelatedWork W2057640177 @default.
• W4296236224 hasRelatedWork W2149614267 @default.
• W4296236224 hasRelatedWork W2469247447 @default.
• W4296236224 hasRelatedWork W2748952813 @default.
• W4296236224 hasRelatedWork W2806991430 @default.
• W4296236224 hasRelatedWork W2897496508 @default.
• W4296236224 hasRelatedWork W2899084033 @default.
• W4296236224 hasRelatedWork W2917256527 @default.
• W4296236224 hasRelatedWork W3028202721 @default.
• W4296236224 hasRelatedWork W3107474891 @default.

• next