FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296248977> ?p ?o ?g. }

• W4296248977 endingPage "387" @default.
• W4296248977 startingPage "379" @default.
• W4296248977 abstract "Abstract Background The aetiology of breast cancers diagnosed ≤ 50 years of age remains unclear. We aimed to compare reproductive risk factors between molecular subtypes of breast cancer, thereby suggesting possible aetiologic clues, using routinely collected cancer registry and maternity data in Scotland. Methods We conducted a cross-sectional study of 4108 women aged ≤ 50 years with primary breast cancer diagnosed between 2009 and 2016 linked to maternity data. Molecular subtypes of breast cancer were defined using immunohistochemistry (IHC) tumour markers, oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER2), and tumour grade. Age-adjusted polytomous logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association of number of births, age at first birth and time since last birth with IHC-defined breast cancer subtypes. Luminal A-like was the reference compared to luminal B-like (HER2−), luminal B-like (HER2+), HER2-overexpressed and triple-negative breast cancer (TNBC). Results Mean (SD) for number of births, age at first birth and time since last birth was 1.4 (1.2) births, 27.2 (6.1) years and 11.0 (6.8) years, respectively. Luminal A-like was the most common subtype (40%), while HER2-overexpressed and TNBC represented 5% and 15% of cases, respectively. Larger numbers of births were recorded among women with HER2-overexpressed and TNBC compared with luminal A-like tumours (> 3 vs 0 births, OR 1.87, 95%CI 1.18–2.96; OR 1.44, 95%CI 1.07–1.94, respectively). Women with their most recent birth > 10 years compared to < 2 years were less likely to have TNBC tumours compared to luminal A-like (OR 0.63, 95%CI 0.41–0.97). We found limited evidence for differences by subtype with age at first birth. Conclusion Number of births and time since last birth differed by molecular subtypes of breast cancer among women aged ≤ 50 years. Analyses using linked routine electronic medical records by molecularly defined tumour pathology data can be used to investigate the aetiology and prognosis of cancer." @default.
• W4296248977 created "2022-09-19" @default.
• W4296248977 creator A5007286394 @default.
• W4296248977 creator A5024821010 @default.
• W4296248977 creator A5042176392 @default.
• W4296248977 creator A5043150762 @default.
• W4296248977 creator A5055747898 @default.
• W4296248977 creator A5080125366 @default.
• W4296248977 creator A5081401762 @default.
• W4296248977 date "2022-09-18" @default.
• W4296248977 modified "2023-10-18" @default.
• W4296248977 title "Reproductive history differs by molecular subtypes of breast cancer among women aged ≤ 50 years in Scotland diagnosed 2009–2016: a cross-sectional study" @default.
• W4296248977 cites W1723129825 @default.
• W4296248977 cites W1824488209 @default.
• W4296248977 cites W1973274902 @default.
• W4296248977 cites W1980294831 @default.
• W4296248977 cites W2003663277 @default.
• W4296248977 cites W2017047594 @default.
• W4296248977 cites W2019458473 @default.
• W4296248977 cites W2043202631 @default.
• W4296248977 cites W2044702943 @default.
• W4296248977 cites W2065569072 @default.
• W4296248977 cites W2076182452 @default.
• W4296248977 cites W2081452999 @default.
• W4296248977 cites W2085187751 @default.
• W4296248977 cites W2093585770 @default.
• W4296248977 cites W2095305396 @default.
• W4296248977 cites W2097255042 @default.
• W4296248977 cites W2112125488 @default.
• W4296248977 cites W2115303291 @default.
• W4296248977 cites W2122889158 @default.
• W4296248977 cites W2126275835 @default.
• W4296248977 cites W2126293923 @default.
• W4296248977 cites W2127057139 @default.
• W4296248977 cites W2132893003 @default.
• W4296248977 cites W2137161531 @default.
• W4296248977 cites W2147842136 @default.
• W4296248977 cites W2155533563 @default.
• W4296248977 cites W2165724265 @default.
• W4296248977 cites W2259802687 @default.
• W4296248977 cites W2261427161 @default.
• W4296248977 cites W2444539661 @default.
• W4296248977 cites W2497572040 @default.
• W4296248977 cites W2503123240 @default.
• W4296248977 cites W2558484066 @default.
• W4296248977 cites W2575702899 @default.
• W4296248977 cites W2581601910 @default.
• W4296248977 cites W2767497132 @default.
• W4296248977 cites W2782942057 @default.
• W4296248977 cites W2785547116 @default.
• W4296248977 cites W2829068939 @default.
• W4296248977 cites W2890674638 @default.
• W4296248977 cites W2904341199 @default.
• W4296248977 cites W2909714593 @default.
• W4296248977 cites W2923084911 @default.
• W4296248977 cites W2972904252 @default.
• W4296248977 cites W3010898346 @default.
• W4296248977 cites W3036766775 @default.
• W4296248977 cites W3096816962 @default.
• W4296248977 cites W3128646645 @default.
• W4296248977 cites W4289035535 @default.
• W4296248977 doi "https://doi.org/10.1007/s10549-022-06721-1" @default.
• W4296248977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36116093" @default.
• W4296248977 hasPublicationYear "2022" @default.
• W4296248977 type Work @default.
• W4296248977 citedByCount "0" @default.
• W4296248977 crossrefType "journal-article" @default.
• W4296248977 hasAuthorship W4296248977A5007286394 @default.
• W4296248977 hasAuthorship W4296248977A5024821010 @default.
• W4296248977 hasAuthorship W4296248977A5042176392 @default.
• W4296248977 hasAuthorship W4296248977A5043150762 @default.
• W4296248977 hasAuthorship W4296248977A5055747898 @default.
• W4296248977 hasAuthorship W4296248977A5080125366 @default.
• W4296248977 hasAuthorship W4296248977A5081401762 @default.
• W4296248977 hasBestOaLocation W42962489771 @default.
• W4296248977 hasConcept C121608353 @default.
• W4296248977 hasConcept C126322002 @default.
• W4296248977 hasConcept C131872663 @default.
• W4296248977 hasConcept C142052008 @default.
• W4296248977 hasConcept C142724271 @default.
• W4296248977 hasConcept C143998085 @default.
• W4296248977 hasConcept C151956035 @default.
• W4296248977 hasConcept C156957248 @default.
• W4296248977 hasConcept C2780110267 @default.
• W4296248977 hasConcept C29456083 @default.
• W4296248977 hasConcept C44249647 @default.
• W4296248977 hasConcept C530470458 @default.
• W4296248977 hasConcept C71924100 @default.
• W4296248977 hasConcept C84606932 @default.
• W4296248977 hasConcept C98717036 @default.
• W4296248977 hasConceptScore W4296248977C121608353 @default.
• W4296248977 hasConceptScore W4296248977C126322002 @default.
• W4296248977 hasConceptScore W4296248977C131872663 @default.
• W4296248977 hasConceptScore W4296248977C142052008 @default.
• W4296248977 hasConceptScore W4296248977C142724271 @default.
• W4296248977 hasConceptScore W4296248977C143998085 @default.
• W4296248977 hasConceptScore W4296248977C151956035 @default.
• W4296248977 hasConceptScore W4296248977C156957248 @default.

• next