Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296251489> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4296251489 endingPage "122148" @default.
- W4296251489 startingPage "122148" @default.
- W4296251489 abstract "Fascioliasis, a common parasitic infection observed in the pediatric patient population, is a leading cause of concern in countries with poor/unhealthy water resources. To treat this condition first line agent such as triclabendazole (TBZ) has been the choice therapy. However, there is a major hurdle in exploiting TBZ. Characterized with poor aqueous solubility (0.1 mg/L), its solubility has been the rate limiting factor, rendering requirement of large doses of TBZ. To address the same, the focus of the current study was to develop a self-nano emulsifying drug delivery system (TBZ-SNEDDS) for TBZ and developing dose customizable pediatric dispersible color-coded tablets. TBZ-SNEDDS were successfully formulated by using Kolliphor®EL, as a surfactant, a lipid phase of medium chain triglyceride and α-tocopherol in the ratio of (1:1), with dimethylacetamide (DMA) as a solvent. It was observed during in vitro release studies that there was a significant effect of fed conditions on the rate of TBZ release from the formulation. greater than 85 % TBZ was observed to release in fed conditions in comparison to fasted conditions. As currently TBZ is prescribed on a weight-based dosage regimen, it is imperative to develop a dose-customizable fast dissolving pediatric formulation. Hence, TBZ-SNEDDS could prove to be pivotal in helping countless children around the world in desperate conditions to get cheap yet effective therapy." @default.
- W4296251489 created "2022-09-19" @default.
- W4296251489 creator A5011840568 @default.
- W4296251489 creator A5036638461 @default.
- W4296251489 creator A5081881235 @default.
- W4296251489 creator A5087896760 @default.
- W4296251489 date "2022-10-01" @default.
- W4296251489 modified "2023-09-25" @default.
- W4296251489 title "Rebuttal, Replying to the “Letter to the Editor” entitled “Questionable micelle formation of the double hydrophilic block copolymer PEG-pHPMA”" @default.
- W4296251489 cites W1537081151 @default.
- W4296251489 cites W2049185103 @default.
- W4296251489 cites W2518627595 @default.
- W4296251489 cites W3019130660 @default.
- W4296251489 cites W3127935232 @default.
- W4296251489 cites W3162924348 @default.
- W4296251489 cites W3183130434 @default.
- W4296251489 cites W3201203528 @default.
- W4296251489 cites W4247337628 @default.
- W4296251489 doi "https://doi.org/10.1016/j.ijpharm.2022.122148" @default.
- W4296251489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36130860" @default.
- W4296251489 hasPublicationYear "2022" @default.
- W4296251489 type Work @default.
- W4296251489 citedByCount "0" @default.
- W4296251489 crossrefType "journal-article" @default.
- W4296251489 hasAuthorship W4296251489A5011840568 @default.
- W4296251489 hasAuthorship W4296251489A5036638461 @default.
- W4296251489 hasAuthorship W4296251489A5081881235 @default.
- W4296251489 hasAuthorship W4296251489A5087896760 @default.
- W4296251489 hasConcept C11268172 @default.
- W4296251489 hasConcept C155574463 @default.
- W4296251489 hasConcept C178790620 @default.
- W4296251489 hasConcept C184651966 @default.
- W4296251489 hasConcept C185592680 @default.
- W4296251489 hasConcept C71924100 @default.
- W4296251489 hasConcept C98274493 @default.
- W4296251489 hasConceptScore W4296251489C11268172 @default.
- W4296251489 hasConceptScore W4296251489C155574463 @default.
- W4296251489 hasConceptScore W4296251489C178790620 @default.
- W4296251489 hasConceptScore W4296251489C184651966 @default.
- W4296251489 hasConceptScore W4296251489C185592680 @default.
- W4296251489 hasConceptScore W4296251489C71924100 @default.
- W4296251489 hasConceptScore W4296251489C98274493 @default.
- W4296251489 hasLocation W42962514891 @default.
- W4296251489 hasLocation W42962514892 @default.
- W4296251489 hasOpenAccess W4296251489 @default.
- W4296251489 hasPrimaryLocation W42962514891 @default.
- W4296251489 hasRelatedWork W1184022130 @default.
- W4296251489 hasRelatedWork W1983464871 @default.
- W4296251489 hasRelatedWork W2008059695 @default.
- W4296251489 hasRelatedWork W2014422782 @default.
- W4296251489 hasRelatedWork W2050462713 @default.
- W4296251489 hasRelatedWork W2089503686 @default.
- W4296251489 hasRelatedWork W2391982268 @default.
- W4296251489 hasRelatedWork W3024223573 @default.
- W4296251489 hasRelatedWork W3043749580 @default.
- W4296251489 hasRelatedWork W3049453080 @default.
- W4296251489 hasVolume "626" @default.
- W4296251489 isParatext "false" @default.
- W4296251489 isRetracted "false" @default.
- W4296251489 workType "article" @default.