FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296260788> ?p ?o ?g. }

• W4296260788 abstract "The indispensability of primary cilia in skeletal development has been widely recognized. We have previously shown that intraflagellar transport 140 (IFT140), a protein component of a bidirectional intraflagellar transport system required for ciliary function, controls bone development and dentinogenesis. However, it remains unknown whether IFT140 functionally contributes to bone fracture rehabilitation. Here an osteotomy-induced femoral fracture model was generated in Ift140-transgenic (Ift140-TG) and osteoblast-specific Ift140-conditional knockout (Ift140-cKO) mice. Micro-computed tomography, osteogenic induction, qualitative polymerase chain reaction, and toluidine blue and safranin O/fast green staining assays were used to characterize the dynamics of bone fracture healing from various perspectives. We found that IFT140 was relatively enriched in the bone callus and decreased in fracture-susceptible aged, or diabetic bones. Ift140-cKO mice had impaired osteogenic differentiation from bone mesenchymal stem cells, lower bone mass, and delayed fracture closure, whereas Ift140-TG mice had promising healing outcomes. Overall, our findings demonstrated for the first time that IFT140 has a beneficial role in fracture repair. Future investigation of the primary cilium in the context of aging and osteoporosis would certainly benefit patients at high risk of bone fractures." @default.
• W4296260788 created "2022-09-19" @default.
• W4296260788 creator A5002934294 @default.
• W4296260788 creator A5012088353 @default.
• W4296260788 creator A5013970773 @default.
• W4296260788 creator A5024438596 @default.
• W4296260788 creator A5049313599 @default.
• W4296260788 creator A5056540270 @default.
• W4296260788 creator A5056545246 @default.
• W4296260788 creator A5069464491 @default.
• W4296260788 creator A5073439342 @default.
• W4296260788 date "2022-09-01" @default.
• W4296260788 modified "2023-09-30" @default.
• W4296260788 title "Loss of intraflagellar transport 140 in osteoblasts cripples bone fracture healing" @default.
• W4296260788 cites W1997455881 @default.
• W4296260788 cites W2016689947 @default.
• W4296260788 cites W2020730431 @default.
• W4296260788 cites W2130607897 @default.
• W4296260788 cites W2138844665 @default.
• W4296260788 cites W2138889138 @default.
• W4296260788 cites W2269475172 @default.
• W4296260788 cites W2408425935 @default.
• W4296260788 cites W2590729753 @default.
• W4296260788 cites W2773627761 @default.
• W4296260788 cites W2807361643 @default.
• W4296260788 cites W2913985590 @default.
• W4296260788 cites W2934107946 @default.
• W4296260788 cites W2943235479 @default.
• W4296260788 cites W2944598382 @default.
• W4296260788 cites W2954185030 @default.
• W4296260788 cites W2965526879 @default.
• W4296260788 cites W2981860717 @default.
• W4296260788 cites W2990517472 @default.
• W4296260788 cites W3020226284 @default.
• W4296260788 cites W3022728020 @default.
• W4296260788 cites W3094367396 @default.
• W4296260788 cites W3101970418 @default.
• W4296260788 cites W3165023024 @default.
• W4296260788 cites W3195195170 @default.
• W4296260788 cites W3195883976 @default.
• W4296260788 cites W3200250351 @default.
• W4296260788 cites W3211636670 @default.
• W4296260788 doi "https://doi.org/10.1016/j.fmre.2022.09.006" @default.
• W4296260788 hasPublicationYear "2022" @default.
• W4296260788 type Work @default.
• W4296260788 citedByCount "0" @default.
• W4296260788 crossrefType "journal-article" @default.
• W4296260788 hasAuthorship W4296260788A5002934294 @default.
• W4296260788 hasAuthorship W4296260788A5012088353 @default.
• W4296260788 hasAuthorship W4296260788A5013970773 @default.
• W4296260788 hasAuthorship W4296260788A5024438596 @default.
• W4296260788 hasAuthorship W4296260788A5049313599 @default.
• W4296260788 hasAuthorship W4296260788A5056540270 @default.
• W4296260788 hasAuthorship W4296260788A5056545246 @default.
• W4296260788 hasAuthorship W4296260788A5069464491 @default.
• W4296260788 hasAuthorship W4296260788A5073439342 @default.
• W4296260788 hasBestOaLocation W42962607881 @default.
• W4296260788 hasConcept C100094513 @default.
• W4296260788 hasConcept C104317684 @default.
• W4296260788 hasConcept C105702510 @default.
• W4296260788 hasConcept C115811362 @default.
• W4296260788 hasConcept C126838900 @default.
• W4296260788 hasConcept C127716648 @default.
• W4296260788 hasConcept C151730666 @default.
• W4296260788 hasConcept C164659718 @default.
• W4296260788 hasConcept C185592680 @default.
• W4296260788 hasConcept C202751555 @default.
• W4296260788 hasConcept C2776441800 @default.
• W4296260788 hasConcept C2778260815 @default.
• W4296260788 hasConcept C2779343474 @default.
• W4296260788 hasConcept C37590093 @default.
• W4296260788 hasConcept C55493867 @default.
• W4296260788 hasConcept C71924100 @default.
• W4296260788 hasConcept C8337478 @default.
• W4296260788 hasConcept C86803240 @default.
• W4296260788 hasConcept C95444343 @default.
• W4296260788 hasConceptScore W4296260788C100094513 @default.
• W4296260788 hasConceptScore W4296260788C104317684 @default.
• W4296260788 hasConceptScore W4296260788C105702510 @default.
• W4296260788 hasConceptScore W4296260788C115811362 @default.
• W4296260788 hasConceptScore W4296260788C126838900 @default.
• W4296260788 hasConceptScore W4296260788C127716648 @default.
• W4296260788 hasConceptScore W4296260788C151730666 @default.
• W4296260788 hasConceptScore W4296260788C164659718 @default.
• W4296260788 hasConceptScore W4296260788C185592680 @default.
• W4296260788 hasConceptScore W4296260788C202751555 @default.
• W4296260788 hasConceptScore W4296260788C2776441800 @default.
• W4296260788 hasConceptScore W4296260788C2778260815 @default.
• W4296260788 hasConceptScore W4296260788C2779343474 @default.
• W4296260788 hasConceptScore W4296260788C37590093 @default.
• W4296260788 hasConceptScore W4296260788C55493867 @default.
• W4296260788 hasConceptScore W4296260788C71924100 @default.
• W4296260788 hasConceptScore W4296260788C8337478 @default.
• W4296260788 hasConceptScore W4296260788C86803240 @default.
• W4296260788 hasConceptScore W4296260788C95444343 @default.
• W4296260788 hasLocation W42962607881 @default.
• W4296260788 hasOpenAccess W4296260788 @default.
• W4296260788 hasPrimaryLocation W42962607881 @default.
• W4296260788 hasRelatedWork W1503876310 @default.
• W4296260788 hasRelatedWork W2000301861 @default.

• next