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- W4296266888 abstract "Abstract Emerging pathogens can have devastating effects on naïve hosts, but disease outcomes often vary among host species. Comparing the cellular response of different hosts to infection can provide insight into mechanisms of host defence. Here, we used RNA‐seq to characterize the transcriptomic response of Darwin's finches to avian poxvirus, a disease of concern in the Galápagos Islands. We tested whether gene expression differs between infected and uninfected birds, and whether transcriptomic differences were related either to known antiviral mechanisms and/or the co‐option of the host cellular environment by the virus. We compared two species, the medium ground finch ( Geospiza fortis ) and the vegetarian finch ( Platyspiza crassirostris ), to determine whether endemic Galápagos species differ in their response to pox. We found that medium ground finches had a strong transcriptomic response to infection, upregulating genes involved in the innate immune response including interferon production, inflammation, and other immune signalling pathways. In contrast, vegetarian finches had a more limited response, and some changes in this species were consistent with viral manipulation of the host's cellular function and metabolism. Many of the transcriptomic changes mirrored responses documented in model and in vitro studies of poxviruses. Our results thus indicate that many pathways of host defence against poxviruses are conserved among vertebrates and present even in hosts without a long evolutionary history with the virus. At the same time, the differences we observed between closely related species suggests that some endemic species of Galápagos finch could be more susceptible to avian pox than others." @default.
- W4296266888 created "2022-09-19" @default.
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- W4296266888 date "2022-09-26" @default.
- W4296266888 modified "2023-09-29" @default.
- W4296266888 title "Transcriptomic responses of Galápagos finches to avian poxvirus infection" @default.
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- W4296266888 doi "https://doi.org/10.1111/mec.16690" @default.
- W4296266888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36086992" @default.
- W4296266888 hasPublicationYear "2022" @default.
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