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- W4296267817 abstract "Background: Type-one diabetes (T1D), a chronic autoimmune disease with marked inflammatory responses, is associated with infertility complications and implications. Based on the anti-diabetic, antioxidant, and anti-hyperlipidemic potential of Portulaca oleracea (PO), this study aimed to evaluate the protective effect of this plant extract on streptozotocin-induced type-I-diabetes-associated reproductive system dysfunction and inflammation. Methods: Male rats were randomly divided into four experimental groups: control, diabetic, and treatment/s (PO extract at 100 or 300 mg/kg/daily). Then food and water consumption, body, testis and epididymis weights, histopathological evaluation, seminiferous tubules diameter, sperm count and motility, glucose levels, sex hormones, and inflammatory and oxidative stress markers were evaluated. Results: Our results showed that streptozotocin-induced diabetes significantly increased food and water consumption; increased glucose, MDA, TGF-β1, and TNF-α levels; and decreased the seminiferous tubules diameter, sperm count and motility, levels of LH, testosterone, total thiol, VEGF, and SOD activity. Interestingly, PO extract (phytochemically characterized by using liquid chromatography–mass spectrometry to detect bioactive molecules) significantly ameliorated these parameters and histopathological indexes’ damage in rats. Conclusion. Even if more preclinical assessments are needed to better characterize the mechanism/s of action, the results of this study will pave the way for the rational use of PO on diabetic-associated clinical complications and implications." @default.
- W4296267817 created "2022-09-19" @default.
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- W4296267817 date "2022-09-17" @default.
- W4296267817 modified "2023-10-18" @default.
- W4296267817 title "Protective Effect of Portulaca oleracea on Streptozotocin-Induced Type I Diabetes-Associated Reproductive System Dysfunction and Inflammation" @default.
- W4296267817 cites W1536141833 @default.
- W4296267817 cites W1550330319 @default.
- W4296267817 cites W1586503364 @default.
- W4296267817 cites W1888759561 @default.
- W4296267817 cites W1970002533 @default.
- W4296267817 cites W1970276520 @default.
- W4296267817 cites W1976679183 @default.
- W4296267817 cites W1983837156 @default.
- W4296267817 cites W1994306531 @default.
- W4296267817 cites W1997609942 @default.
- W4296267817 cites W2004730294 @default.
- W4296267817 cites W2005796344 @default.
- W4296267817 cites W2012646526 @default.
- W4296267817 cites W2014532026 @default.
- W4296267817 cites W2026277176 @default.
- W4296267817 cites W2033944234 @default.
- W4296267817 cites W2034921827 @default.
- W4296267817 cites W2041767510 @default.
- W4296267817 cites W2042649578 @default.
- W4296267817 cites W2049210214 @default.
- W4296267817 cites W2049937845 @default.
- W4296267817 cites W2050005812 @default.
- W4296267817 cites W2054036171 @default.
- W4296267817 cites W2064085069 @default.
- W4296267817 cites W2089934054 @default.
- W4296267817 cites W2090393009 @default.
- W4296267817 cites W2093922657 @default.
- W4296267817 cites W2093975264 @default.
- W4296267817 cites W2112191611 @default.
- W4296267817 cites W2118205426 @default.
- W4296267817 cites W2119304571 @default.
- W4296267817 cites W2120212949 @default.
- W4296267817 cites W2123510813 @default.
- W4296267817 cites W2123671921 @default.
- W4296267817 cites W2125968610 @default.
- W4296267817 cites W2128390299 @default.
- W4296267817 cites W2140072587 @default.
- W4296267817 cites W2144014980 @default.
- W4296267817 cites W2159416433 @default.
- W4296267817 cites W2169305592 @default.
- W4296267817 cites W2237033277 @default.
- W4296267817 cites W2268527404 @default.
- W4296267817 cites W2336817397 @default.
- W4296267817 cites W2462096982 @default.
- W4296267817 cites W2483077624 @default.
- W4296267817 cites W2555368980 @default.
- W4296267817 cites W2568451132 @default.
- W4296267817 cites W2579787940 @default.
- W4296267817 cites W2589473806 @default.
- W4296267817 cites W2774743973 @default.
- W4296267817 cites W2781873092 @default.
- W4296267817 cites W2789953486 @default.
- W4296267817 cites W2790776377 @default.
- W4296267817 cites W2795420872 @default.
- W4296267817 cites W2821881508 @default.
- W4296267817 cites W2883289270 @default.
- W4296267817 cites W2899168667 @default.
- W4296267817 cites W2907677510 @default.
- W4296267817 cites W2912963935 @default.
- W4296267817 cites W2920898291 @default.
- W4296267817 cites W2923429175 @default.
- W4296267817 cites W2925260201 @default.
- W4296267817 cites W2927435434 @default.
- W4296267817 cites W2944544314 @default.
- W4296267817 cites W2951680676 @default.
- W4296267817 cites W2972869264 @default.
- W4296267817 cites W3011279621 @default.
- W4296267817 cites W3033588563 @default.
- W4296267817 cites W3086984767 @default.
- W4296267817 cites W3095045330 @default.
- W4296267817 cites W3130905873 @default.
- W4296267817 cites W3154875337 @default.
- W4296267817 cites W3156494517 @default.
- W4296267817 cites W3163472963 @default.
- W4296267817 cites W3188138729 @default.
- W4296267817 cites W3193192169 @default.
- W4296267817 cites W4253817277 @default.
- W4296267817 doi "https://doi.org/10.3390/molecules27186075" @default.
- W4296267817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36144807" @default.
- W4296267817 hasPublicationYear "2022" @default.
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