Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296301461> ?p ?o ?g. }
- W4296301461 endingPage "121807" @default.
- W4296301461 startingPage "121807" @default.
- W4296301461 abstract "We hypothesized that the host microbiome may influence foreign body responses following biomaterial implantation. To test this, we implanted a variety of clinically relevant biomaterials into germ-free or antibiotic-treated mice. Surprisingly, these mice displayed less fibrous tissue deposition, reduced host cell recruitment to the implant site, and differential expression of angiogenic and inflammatory markers. These observations were reversed upon fecal microbiome reconstitution, confirming a causal role of the host microbiome. In a clinically relevant disease model, microbiome-depleted mice cleared hyaluronic acid and bone marrow mononuclear cells from ischemic hind limb tissues more slowly, resulting in an improved therapeutic response. Findings were confirmed in pigs which showed reduced fibrotic responses to a variety of implanted materials. Lastly, we profiled changes in the host microbiome following material implantation, implicating several key bacteria phyla." @default.
- W4296301461 created "2022-09-19" @default.
- W4296301461 creator A5008596372 @default.
- W4296301461 creator A5025015296 @default.
- W4296301461 creator A5025072573 @default.
- W4296301461 creator A5038200268 @default.
- W4296301461 creator A5053209567 @default.
- W4296301461 creator A5054802081 @default.
- W4296301461 creator A5059343029 @default.
- W4296301461 creator A5068897692 @default.
- W4296301461 creator A5072228476 @default.
- W4296301461 creator A5073884080 @default.
- W4296301461 creator A5090508429 @default.
- W4296301461 date "2022-10-01" @default.
- W4296301461 modified "2023-10-18" @default.
- W4296301461 title "The gut microbiota regulates acute foreign body reaction and tissue repair after biomaterial implantation" @default.
- W4296301461 cites W1482515349 @default.
- W4296301461 cites W1918132278 @default.
- W4296301461 cites W1968596406 @default.
- W4296301461 cites W2023506796 @default.
- W4296301461 cites W2051278851 @default.
- W4296301461 cites W2072064533 @default.
- W4296301461 cites W2077553363 @default.
- W4296301461 cites W2106944257 @default.
- W4296301461 cites W2113552312 @default.
- W4296301461 cites W2116846792 @default.
- W4296301461 cites W2124632458 @default.
- W4296301461 cites W2128695989 @default.
- W4296301461 cites W2133856765 @default.
- W4296301461 cites W2143996426 @default.
- W4296301461 cites W2260859913 @default.
- W4296301461 cites W2381299150 @default.
- W4296301461 cites W2461853012 @default.
- W4296301461 cites W2467200611 @default.
- W4296301461 cites W2552730765 @default.
- W4296301461 cites W2555487689 @default.
- W4296301461 cites W2598919558 @default.
- W4296301461 cites W2599718320 @default.
- W4296301461 cites W2616296979 @default.
- W4296301461 cites W2785553342 @default.
- W4296301461 cites W2886282415 @default.
- W4296301461 cites W2891057921 @default.
- W4296301461 cites W2895403307 @default.
- W4296301461 cites W2896600834 @default.
- W4296301461 cites W2899852374 @default.
- W4296301461 cites W2900697674 @default.
- W4296301461 cites W2952564192 @default.
- W4296301461 cites W2963276645 @default.
- W4296301461 cites W2967185215 @default.
- W4296301461 cites W2969684055 @default.
- W4296301461 cites W2989764828 @default.
- W4296301461 cites W2995878355 @default.
- W4296301461 cites W3013859689 @default.
- W4296301461 cites W3027262121 @default.
- W4296301461 cites W3035053176 @default.
- W4296301461 cites W3039929706 @default.
- W4296301461 cites W3085310956 @default.
- W4296301461 cites W3097338697 @default.
- W4296301461 cites W3119859966 @default.
- W4296301461 cites W3125291951 @default.
- W4296301461 cites W3126673609 @default.
- W4296301461 cites W3161185190 @default.
- W4296301461 cites W3165816312 @default.
- W4296301461 cites W3177044329 @default.
- W4296301461 cites W3184669190 @default.
- W4296301461 cites W3210640813 @default.
- W4296301461 cites W4200245074 @default.
- W4296301461 doi "https://doi.org/10.1016/j.biomaterials.2022.121807" @default.
- W4296301461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36166894" @default.
- W4296301461 hasPublicationYear "2022" @default.
- W4296301461 type Work @default.
- W4296301461 citedByCount "2" @default.
- W4296301461 countsByYear W42963014612023 @default.
- W4296301461 crossrefType "journal-article" @default.
- W4296301461 hasAuthorship W4296301461A5008596372 @default.
- W4296301461 hasAuthorship W4296301461A5025015296 @default.
- W4296301461 hasAuthorship W4296301461A5025072573 @default.
- W4296301461 hasAuthorship W4296301461A5038200268 @default.
- W4296301461 hasAuthorship W4296301461A5053209567 @default.
- W4296301461 hasAuthorship W4296301461A5054802081 @default.
- W4296301461 hasAuthorship W4296301461A5059343029 @default.
- W4296301461 hasAuthorship W4296301461A5068897692 @default.
- W4296301461 hasAuthorship W4296301461A5072228476 @default.
- W4296301461 hasAuthorship W4296301461A5073884080 @default.
- W4296301461 hasAuthorship W4296301461A5090508429 @default.
- W4296301461 hasConcept C136229726 @default.
- W4296301461 hasConcept C142724271 @default.
- W4296301461 hasConcept C143121216 @default.
- W4296301461 hasConcept C203014093 @default.
- W4296301461 hasConcept C2778414984 @default.
- W4296301461 hasConcept C2780007613 @default.
- W4296301461 hasConcept C2780942790 @default.
- W4296301461 hasConcept C60644358 @default.
- W4296301461 hasConcept C71924100 @default.
- W4296301461 hasConcept C86803240 @default.
- W4296301461 hasConcept C89423630 @default.
- W4296301461 hasConcept C95444343 @default.
- W4296301461 hasConceptScore W4296301461C136229726 @default.