FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296323662> ?p ?o ?g. }

• W4296323662 endingPage "R693" @default.
• W4296323662 startingPage "R682" @default.
• W4296323662 abstract "Storage and voiding functions in urinary bladder are well-known, yet fundamental physiological events coordinating these behaviors remain elusive. We sought to understand how voiding function is influenced by the rate at which the bladder fills. We hypothesized that faster filling rates would increase afferent sensory activity and increase micturition rate. In vivo, this would mean animals experiencing faster bladder filling would void more frequently with smaller void volumes. To test this hypothesis, we measured afferent nerve activity during different filling rates using an ex vivo mouse bladder preparation and assessed voiding frequency in normally behaving mice noninvasively (UroVoid). Bladder afferent nerve activity depended on the filling rate, with faster filling increasing afferent nerve activity at a given volume. Voiding behavior in vivo was measured in UroVoid cages. Male and female mice were given access to tap water or, to induce faster bladder filling rates, water containing 5% sucrose. Fluid intake increased dramatically in mice consuming 5% sucrose. As expected, micturition frequency was elevated in the sucrose group. However, even with the greatly increased rate of urine production, void volumes were unchanged in both genders. Although faster filling rates generated higher afferent nerve rates ex vivo, this did not translate into more frequent, smaller-volume voids in vivo. This suggests afferent nerve activity is only one factor contributing to the switch from bladder filling to micturition. Together with afferent nerve activity, higher centers in the central nervous system and the state of arousal are likely critical to coordinating the micturition reflex." @default.
• W4296323662 created "2022-09-20" @default.
• W4296323662 creator A5007365638 @default.
• W4296323662 creator A5048090770 @default.
• W4296323662 creator A5053147031 @default.
• W4296323662 creator A5083362507 @default.
• W4296323662 date "2022-11-01" @default.
• W4296323662 modified "2023-09-30" @default.
• W4296323662 title "Afferent nerve activity in a mouse model increases with faster bladder filling rates in vitro, but voiding behavior remains unaltered in vivo" @default.
• W4296323662 cites W134695497 @default.
• W4296323662 cites W1490106730 @default.
• W4296323662 cites W1978838803 @default.
• W4296323662 cites W1999606060 @default.
• W4296323662 cites W2008969125 @default.
• W4296323662 cites W2011149743 @default.
• W4296323662 cites W2013956200 @default.
• W4296323662 cites W2018489619 @default.
• W4296323662 cites W2029949538 @default.
• W4296323662 cites W2039617311 @default.
• W4296323662 cites W2050055410 @default.
• W4296323662 cites W2060915281 @default.
• W4296323662 cites W2137384640 @default.
• W4296323662 cites W2153762549 @default.
• W4296323662 cites W2158914805 @default.
• W4296323662 cites W2159456498 @default.
• W4296323662 cites W2163502299 @default.
• W4296323662 cites W2167804359 @default.
• W4296323662 cites W2301223913 @default.
• W4296323662 cites W2418890105 @default.
• W4296323662 cites W2476934550 @default.
• W4296323662 cites W2523101893 @default.
• W4296323662 cites W2593450222 @default.
• W4296323662 cites W2594028599 @default.
• W4296323662 cites W2887711694 @default.
• W4296323662 cites W2904495069 @default.
• W4296323662 cites W2908874880 @default.
• W4296323662 cites W2964384112 @default.
• W4296323662 cites W3040640042 @default.
• W4296323662 cites W3100320478 @default.
• W4296323662 cites W3197659322 @default.
• W4296323662 cites W4241550402 @default.
• W4296323662 doi "https://doi.org/10.1152/ajpregu.00156.2022" @default.
• W4296323662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36121145" @default.
• W4296323662 hasPublicationYear "2022" @default.
• W4296323662 type Work @default.
• W4296323662 citedByCount "3" @default.
• W4296323662 countsByYear W42963236622023 @default.
• W4296323662 crossrefType "journal-article" @default.
• W4296323662 hasAuthorship W4296323662A5007365638 @default.
• W4296323662 hasAuthorship W4296323662A5048090770 @default.
• W4296323662 hasAuthorship W4296323662A5053147031 @default.
• W4296323662 hasAuthorship W4296323662A5083362507 @default.
• W4296323662 hasBestOaLocation W42963236621 @default.
• W4296323662 hasConcept C105702510 @default.
• W4296323662 hasConcept C126894567 @default.
• W4296323662 hasConcept C134018914 @default.
• W4296323662 hasConcept C150903083 @default.
• W4296323662 hasConcept C175768497 @default.
• W4296323662 hasConcept C185592680 @default.
• W4296323662 hasConcept C207001950 @default.
• W4296323662 hasConcept C2779263132 @default.
• W4296323662 hasConcept C2779762690 @default.
• W4296323662 hasConcept C42219234 @default.
• W4296323662 hasConcept C71924100 @default.
• W4296323662 hasConcept C77411442 @default.
• W4296323662 hasConcept C86803240 @default.
• W4296323662 hasConceptScore W4296323662C105702510 @default.
• W4296323662 hasConceptScore W4296323662C126894567 @default.
• W4296323662 hasConceptScore W4296323662C134018914 @default.
• W4296323662 hasConceptScore W4296323662C150903083 @default.
• W4296323662 hasConceptScore W4296323662C175768497 @default.
• W4296323662 hasConceptScore W4296323662C185592680 @default.
• W4296323662 hasConceptScore W4296323662C207001950 @default.
• W4296323662 hasConceptScore W4296323662C2779263132 @default.
• W4296323662 hasConceptScore W4296323662C2779762690 @default.
• W4296323662 hasConceptScore W4296323662C42219234 @default.
• W4296323662 hasConceptScore W4296323662C71924100 @default.
• W4296323662 hasConceptScore W4296323662C77411442 @default.
• W4296323662 hasConceptScore W4296323662C86803240 @default.
• W4296323662 hasFunder F4320337357 @default.
• W4296323662 hasIssue "5" @default.
• W4296323662 hasLocation W42963236621 @default.
• W4296323662 hasLocation W42963236622 @default.
• W4296323662 hasLocation W42963236623 @default.
• W4296323662 hasOpenAccess W4296323662 @default.
• W4296323662 hasPrimaryLocation W42963236621 @default.
• W4296323662 hasRelatedWork W188685642 @default.
• W4296323662 hasRelatedWork W1964117362 @default.
• W4296323662 hasRelatedWork W2083934770 @default.
• W4296323662 hasRelatedWork W2091858576 @default.
• W4296323662 hasRelatedWork W2334311845 @default.
• W4296323662 hasRelatedWork W2403329915 @default.
• W4296323662 hasRelatedWork W2404865242 @default.
• W4296323662 hasRelatedWork W2409676275 @default.
• W4296323662 hasRelatedWork W2748952813 @default.
• W4296323662 hasRelatedWork W2994220471 @default.
• W4296323662 hasVolume "323" @default.
• W4296323662 isParatext "false" @default.

• next