Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296323732> ?p ?o ?g. }
- W4296323732 abstract "Abstract In eukaryotic cells, biological activities are executed in distinct cellular compartments or organelles. Canonical organelles with membrane‐bound structures are well understood. Cells also inherently contain versatile membrane‐less organelles (MLOs) that feature liquid or gel‐like bodies. A biophysical process termed liquid–liquid phase separation (LLPS) elucidates how MLOs form through dynamic biomolecule assembly. LLPS‐related molecules often have multivalency, which is essential for low‐affinity inter‐ or intra‐molecule interactions to trigger phase separation. Accumulating evidence shows that LLPS concentrates and organizes desired molecules or segregates unneeded molecules in cells. Thus, MLOs have tunable functional specificity in response to environmental stimuli and metabolic processes. Aberrant LLPS is widely associated with several hallmarks of cancer, including sustained proliferative signaling, growth suppressor evasion, cell death resistance, telomere maintenance, DNA damage repair, etc. Insights into the molecular mechanisms of LLPS provide new insights into cancer therapeutics. Here, the current understanding of the emerging concepts of LLPS and its involvement in cancer are comprehensively reviewed." @default.
- W4296323732 created "2022-09-20" @default.
- W4296323732 creator A5017459777 @default.
- W4296323732 creator A5028710085 @default.
- W4296323732 creator A5044934330 @default.
- W4296323732 creator A5045155907 @default.
- W4296323732 creator A5045309022 @default.
- W4296323732 date "2022-09-18" @default.
- W4296323732 modified "2023-10-14" @default.
- W4296323732 title "Emerging Implications of Phase Separation in Cancer" @default.
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