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- W4296328908 abstract "Dehydroepiandrosterone (DHEA) is the most abundant steroid hormone in primates, which is predominantly synthesized in the adrenal cortex. A characteristic curve of growth and decline of its synthesis during life was observed, together with the corresponding formation of its sulphate ester (DHEAS). High levels of plasma circulating DHEA are suggested as a marker of human longevity, and various pathophysiological conditions lead to a decreased DHEA level, including adrenal insufficiency, severe systemic diseases, acute stress, and anorexia. More recent studies have established the importance of DHEA in the central nervous system (CNS). A specific intranuclear receptor for DHEA has not yet been identified; however, highly specific membrane receptors have been detected in endothelial cells, the heart, kidney, liver, and the brain. Research shows that DHEA and DHEAS, as well as their metabolites, have a wide range of effects on numerous organs and organ systems, which places them in the group of potential pharmacological agents useful in various clinical entities. Their action as neurosteroids is especially interesting due to potential neuroprotective, pro-cognitive, anxiolytic, and antidepressant effects. Evidence from clinical studies supports the use of DHEA in hypoadrenal individuals and in treating depression and associated cognitive disorders. However, there is also an increasing trend of recreational DHEA misuse in healthy people, as it is classified as a dietary supplement in some countries. This article aims to provide a critical review regarding the biological and pharmacological effects of DHEA, its mechanism of action, and potential therapeutic use, especially in CNS disorders." @default.
- W4296328908 created "2022-09-20" @default.
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- W4296328908 date "2023-05-10" @default.
- W4296328908 modified "2023-10-08" @default.
- W4296328908 title "Dehydroepiandrosterone (DHEA): Pharmacological Effects and Potential Therapeutic Application" @default.
- W4296328908 cites W1165140024 @default.
- W4296328908 cites W1526282183 @default.
- W4296328908 cites W1600934558 @default.
- W4296328908 cites W1679218678 @default.
- W4296328908 cites W1882553787 @default.
- W4296328908 cites W1974944534 @default.
- W4296328908 cites W1975511488 @default.
- W4296328908 cites W1976651476 @default.
- W4296328908 cites W1976917710 @default.
- W4296328908 cites W1978530682 @default.
- W4296328908 cites W1980941499 @default.
- W4296328908 cites W1983149607 @default.
- W4296328908 cites W1984917548 @default.
- W4296328908 cites W1989366358 @default.
- W4296328908 cites W1989630160 @default.
- W4296328908 cites W1993292496 @default.
- W4296328908 cites W1993452004 @default.
- W4296328908 cites W1999504845 @default.
- W4296328908 cites W1999886179 @default.
- W4296328908 cites W2002032387 @default.
- W4296328908 cites W2004438781 @default.
- W4296328908 cites W2004801894 @default.
- W4296328908 cites W2005988538 @default.
- W4296328908 cites W2006419717 @default.
- W4296328908 cites W2007631668 @default.
- W4296328908 cites W2008660639 @default.
- W4296328908 cites W2014064649 @default.
- W4296328908 cites W2019716845 @default.
- W4296328908 cites W2021437097 @default.
- W4296328908 cites W2022548509 @default.
- W4296328908 cites W2024496855 @default.
- W4296328908 cites W2026362634 @default.
- W4296328908 cites W2026714211 @default.
- W4296328908 cites W2032898754 @default.
- W4296328908 cites W2035959692 @default.
- W4296328908 cites W2036213950 @default.
- W4296328908 cites W2036812496 @default.
- W4296328908 cites W2037425193 @default.
- W4296328908 cites W2040592517 @default.
- W4296328908 cites W2042430625 @default.
- W4296328908 cites W2045061627 @default.
- W4296328908 cites W2050410922 @default.
- W4296328908 cites W2052801093 @default.
- W4296328908 cites W2052875228 @default.
- W4296328908 cites W2053713082 @default.
- W4296328908 cites W2055777558 @default.
- W4296328908 cites W2056633438 @default.
- W4296328908 cites W2058890887 @default.
- W4296328908 cites W2061510403 @default.
- W4296328908 cites W2062340073 @default.
- W4296328908 cites W2063403392 @default.
- W4296328908 cites W2064310817 @default.
- W4296328908 cites W2066385861 @default.
- W4296328908 cites W2067814358 @default.
- W4296328908 cites W2068228829 @default.
- W4296328908 cites W2071763142 @default.
- W4296328908 cites W2073496120 @default.
- W4296328908 cites W2077566909 @default.
- W4296328908 cites W2082759302 @default.
- W4296328908 cites W2099925523 @default.
- W4296328908 cites W2103001937 @default.
- W4296328908 cites W2106559777 @default.
- W4296328908 cites W2109982376 @default.
- W4296328908 cites W2112485745 @default.
- W4296328908 cites W2119552011 @default.
- W4296328908 cites W2121174488 @default.
- W4296328908 cites W2124246726 @default.
- W4296328908 cites W2130325075 @default.
- W4296328908 cites W2137777161 @default.
- W4296328908 cites W2139191414 @default.
- W4296328908 cites W2139910117 @default.
- W4296328908 cites W2145374663 @default.
- W4296328908 cites W2145801998 @default.
- W4296328908 cites W2146164085 @default.
- W4296328908 cites W2149642946 @default.
- W4296328908 cites W2155833469 @default.
- W4296328908 cites W2156090682 @default.
- W4296328908 cites W2164467473 @default.
- W4296328908 cites W2171621354 @default.
- W4296328908 cites W2312001993 @default.
- W4296328908 cites W2346351244 @default.
- W4296328908 cites W2395453590 @default.
- W4296328908 cites W2610376988 @default.
- W4296328908 cites W2753932456 @default.
- W4296328908 cites W2789987748 @default.
- W4296328908 cites W2790378193 @default.