FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296329144> ?p ?o ?g. }

• W4296329144 endingPage "3085" @default.
• W4296329144 startingPage "3071" @default.
• W4296329144 abstract "Dihydromyricetin (DHM) exerts protective effects in various brain diseases. The aim of this research was to investigate the biological role of DHM in cerebral ischemia reperfusion (I/R) injury.We generated a rat model of cerebral I/R injury by performing middle cerebral artery occlusion/reperfusion (MCAO/R). The neurological score and brain water content of the experimental rats was then evaluated. The infarct volume and extent of apoptosis in brain tissues was then assessed by 2,3,5-triphenyltetrazolium (TTC) and TdT-mediated dUTP nick end labeling (TUNEL) staining. Hippocampal neuronal cells (HT22) were subjected to oxygen-glucose deprivation/reperfusion (OGD/R) and cell counting kit-8 (CCK-8) assays and flow cytometry were performed to detect cell viability and apoptosis. The levels of lipid reactive oxygen species (ROS) and iron were detected and the expression levels of key proteins were assessed by Western blotting.DHM obviously reduced neurological deficits, brain water content, infarct volume and cell apoptosis in the brain tissues of MCAO/R rats. DHM repressed ferroptosis and inhibited the sphingosine kinase 1 (SPHK1)/mammalian target of rapamycin (mTOR) pathway in MCAO/R rats. In addition, DHM promoted cell viability and repressed apoptosis in OGD/R-treated HT22 cells. DHM also suppressed the levels of lipid ROS and intracellular iron in OGD/R-treated HT22 cells. The expression levels of glutathione peroxidase 4 (GPX4) was enhanced while the levels of acyl-CoA synthetase long-chain family member 4 (ACSL4) and phosphatidylethanolamine binding protein 1 (PEBP1) were reduced in OGD/R-treated HT22 cells in the presence of DHM. Moreover, the influence conferred by DHM was abrogated by the overexpression of SPHK1 or treatment with MHY1485 (an activator of mTOR).This research demonstrated that DHM repressed ferroptosis by inhibiting the SPHK1/mTOR signaling pathway, thereby alleviating cerebral I/R injury. Our findings suggest that DHM may be a candidate drug for cerebral I/R injury treatment." @default.
• W4296329144 created "2022-09-20" @default.
• W4296329144 creator A5000971773 @default.
• W4296329144 creator A5008008825 @default.
• W4296329144 creator A5010552097 @default.
• W4296329144 creator A5013297039 @default.
• W4296329144 creator A5046436076 @default.
• W4296329144 creator A5046454314 @default.
• W4296329144 date "2022-09-01" @default.
• W4296329144 modified "2023-10-14" @default.
• W4296329144 title "Dihydromyricetin Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting SPHK1/mTOR Signaling and Targeting Ferroptosis" @default.
• W4296329144 cites W1997183854 @default.
• W4296329144 cites W2087523642 @default.
• W4296329144 cites W2189205651 @default.
• W4296329144 cites W2210473860 @default.
• W4296329144 cites W2265062179 @default.
• W4296329144 cites W2492067543 @default.
• W4296329144 cites W2531638413 @default.
• W4296329144 cites W2607373498 @default.
• W4296329144 cites W2753664146 @default.
• W4296329144 cites W2759395694 @default.
• W4296329144 cites W2792146494 @default.
• W4296329144 cites W2794260661 @default.
• W4296329144 cites W2805666090 @default.
• W4296329144 cites W2890543065 @default.
• W4296329144 cites W2892710900 @default.
• W4296329144 cites W2898097157 @default.
• W4296329144 cites W2899876893 @default.
• W4296329144 cites W2944262472 @default.
• W4296329144 cites W2948351836 @default.
• W4296329144 cites W2981708870 @default.
• W4296329144 cites W2985490000 @default.
• W4296329144 cites W2988395250 @default.
• W4296329144 cites W2994770641 @default.
• W4296329144 cites W3000933596 @default.
• W4296329144 cites W3003960907 @default.
• W4296329144 cites W3007516526 @default.
• W4296329144 cites W3007563346 @default.
• W4296329144 cites W3035851500 @default.
• W4296329144 cites W3042747698 @default.
• W4296329144 cites W3077764649 @default.
• W4296329144 cites W3092745504 @default.
• W4296329144 cites W3110019719 @default.
• W4296329144 cites W3126912132 @default.
• W4296329144 cites W3138634159 @default.
• W4296329144 cites W3157872931 @default.
• W4296329144 cites W3159261210 @default.
• W4296329144 cites W3163967605 @default.
• W4296329144 cites W3165197804 @default.
• W4296329144 cites W3205768401 @default.
• W4296329144 cites W3210906481 @default.
• W4296329144 cites W4211070880 @default.
• W4296329144 cites W4226163023 @default.
• W4296329144 doi "https://doi.org/10.2147/dddt.s378786" @default.
• W4296329144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36118165" @default.
• W4296329144 hasPublicationYear "2022" @default.
• W4296329144 type Work @default.
• W4296329144 citedByCount "7" @default.
• W4296329144 countsByYear W42963291442023 @default.
• W4296329144 crossrefType "journal-article" @default.
• W4296329144 hasAuthorship W4296329144A5000971773 @default.
• W4296329144 hasAuthorship W4296329144A5008008825 @default.
• W4296329144 hasAuthorship W4296329144A5010552097 @default.
• W4296329144 hasAuthorship W4296329144A5013297039 @default.
• W4296329144 hasAuthorship W4296329144A5046436076 @default.
• W4296329144 hasAuthorship W4296329144A5046454314 @default.
• W4296329144 hasBestOaLocation W42963291441 @default.
• W4296329144 hasConcept C126322002 @default.
• W4296329144 hasConcept C153911025 @default.
• W4296329144 hasConcept C185592680 @default.
• W4296329144 hasConcept C190283241 @default.
• W4296329144 hasConcept C196795494 @default.
• W4296329144 hasConcept C25498285 @default.
• W4296329144 hasConcept C2780114680 @default.
• W4296329144 hasConcept C48349386 @default.
• W4296329144 hasConcept C53227056 @default.
• W4296329144 hasConcept C541997718 @default.
• W4296329144 hasConcept C553184892 @default.
• W4296329144 hasConcept C55493867 @default.
• W4296329144 hasConcept C71924100 @default.
• W4296329144 hasConcept C86554907 @default.
• W4296329144 hasConcept C86803240 @default.
• W4296329144 hasConcept C98274493 @default.
• W4296329144 hasConceptScore W4296329144C126322002 @default.
• W4296329144 hasConceptScore W4296329144C153911025 @default.
• W4296329144 hasConceptScore W4296329144C185592680 @default.
• W4296329144 hasConceptScore W4296329144C190283241 @default.
• W4296329144 hasConceptScore W4296329144C196795494 @default.
• W4296329144 hasConceptScore W4296329144C25498285 @default.
• W4296329144 hasConceptScore W4296329144C2780114680 @default.
• W4296329144 hasConceptScore W4296329144C48349386 @default.
• W4296329144 hasConceptScore W4296329144C53227056 @default.
• W4296329144 hasConceptScore W4296329144C541997718 @default.
• W4296329144 hasConceptScore W4296329144C553184892 @default.
• W4296329144 hasConceptScore W4296329144C55493867 @default.
• W4296329144 hasConceptScore W4296329144C71924100 @default.
• W4296329144 hasConceptScore W4296329144C86554907 @default.
• W4296329144 hasConceptScore W4296329144C86803240 @default.

• next