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• W4296334383 endingPage "121014" @default.
• W4296334383 startingPage "121014" @default.
• W4296334383 abstract "This research focuses on a new thermo-responsive membrane bioseparation for the human leukocyte enrichment procedure. While leukocytes should be separated from whole blood for safe transfusion, these cells have long been known as efficient biomarkers for medical diagnostic. However, their low relative amount in the blood stream, compared to platelets and erythrocytes, requires a concentration step. In this study, we developed polypropylene membranes with dual functional properties able to selectively catch leukocytes and release them. In these bio-separators, the selective catching property is endowed by a copolymer composed of N-hydroxyethyl acrylamide (HEAA) and butyl methacrylate, referred to as poly(HEAA-co-BMA). The release property is ensured by thermosensitive brushes N-isopropylacrylamide (NIPAAm) contained in poly(NIPAAm-co-BMA) copolymer. After synthesizing and characterizing copolymers with various molar composition, efforts were oriented towards the optimization of each individual property. It was found that H70B30 and N70B30 copolymers (with 70 mol% HEAA or NIPAAm and 30 mol% BMA), provided the best catching and release property, respectively. Then, membranes were coated with both copolymers, characterized and used to selectively catch and release leukocytes. With white blood cell concentrate as the feed, the platelet/leukocyte ratio could be decreased by a 2-fold factor. Using whole blood, the platelet/leukocyte ratio and erythrocyte/leukocyte ratio were divided by 4 and 45, respectively. In other words, leukocytes can be efficiently concentrated using these novel bio-separators, leading to a highly concentrated solution which could benefit their use as biomarkers in diagnosis." @default.
• W4296334383 created "2022-09-20" @default.
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• W4296334383 date "2022-10-01" @default.
• W4296334383 modified "2023-09-26" @default.
• W4296334383 title "Thermo-responsive bioseparation engineered for human leukocyte enrichment process driven by functionalized polypropylene bio-separators" @default.
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• W4296334383 doi "https://doi.org/10.1016/j.memsci.2022.121014" @default.
• W4296334383 hasPublicationYear "2022" @default.
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