FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296341524> ?p ?o ?g. }

• W4296341524 endingPage "S213" @default.
• W4296341524 startingPage "S213" @default.
• W4296341524 abstract "Introduction: In January 2016, HFHS Transplant Institute began the PROSPECT trial, an interventional trial studying normothermic preservation of the donated liver before transplant using the Liver Organ Care System (OCSTM). The Henry Ford Hospital Transfusion Service (TS) provided the required packed red blood cells (PRBC). Background: The TransMedics (OCSTM) liver trial was an international, randomized trial studying the intervention of a portable liver system to preserve donor livers for transplant. The system utilizes an oxygenated blood-based perfusate mixed with nutrient solution in normothermic perfusion for organ preservation. The TS provided PRBC needed for the study, final PRBC used dictated by the condition and size of the retrieved liver. TS study goal was to secure proper transfusion needs for liver perfusion while also adhering to blood inventory management. Methods: Organ procurement candidates for the PROTECT trial were selected based on pre-determined conditions and consented according to that protocol. Once the patient was consented and the liver transplantation was scheduled, the PROTECT trial team notified the TS,and 5 units of group O Positive, leukoreduced PRBC less than 10 days old were selected, and placed inside a temperature-controlled packaging container along with a remote temperature monitoring device. The container was then transported with the procurement team to the harvesting location. Once the insulated container was returned to the TS, the temperature-monitoring device information was uploaded to verify that the returned PRBC have been stored within their proper temperature limits. Results: The TS support for the PROTECT trial at HFHS occurred from January 2016 until September 2021. The table below shows the activity related to this trial. - Issued Utilized Returned Wasted PRBC units 240 132 104 4 In summary, 29/48 study events used 4 units; 3/48 study events used 5 units; on 15/48 events the organ harvesting was cancelled; all units returned had an acceptable temperature range and returned to the available inventory. For one study event, 4 PRBC were spiked in preparation for use in the perfusate prior to the event being cancelled. These PRBC were discarded and deemed wasted. Conclusions: During the PROTECT trial no PRBCs were wasted due to inappropriate storage conditions. The joint use of a temperature-controlled container and remote temperature monitoring device allowed for the appropriate return of unused PRBCs to the TS blood inventory, thus avoiding any wastage. Only 3/48 events used 5 units, theus issuing 4 PRBC to meet the OCS™ support may suffice, further decreasing the risk for wastage of any PRBC units. After receiving FDA in September 2021, alternatives to maintain the required PRBC temperature should be addressed to minimize wastage at this time of limited blood availability for the support of the TransMedics Organ Care System (OCSTM) for liver organ perfusion." @default.
• W4296341524 created "2022-09-20" @default.
• W4296341524 creator A5039378237 @default.
• W4296341524 creator A5043900419 @default.
• W4296341524 creator A5049761912 @default.
• W4296341524 creator A5071115514 @default.
• W4296341524 date "2022-09-01" @default.
• W4296341524 modified "2023-10-16" @default.
• W4296341524 title "313.5: Meeting Packed Red Blood Cell Requirement for the Transmedics Organ Care System (OCS) Liver Transplantation Trial (PROTECT Trial) At Henry Ford Hospital" @default.
• W4296341524 doi "https://doi.org/10.1097/01.tp.0000886456.96346.d3" @default.
• W4296341524 hasPublicationYear "2022" @default.
• W4296341524 type Work @default.
• W4296341524 citedByCount "0" @default.
• W4296341524 crossrefType "journal-article" @default.
• W4296341524 hasAuthorship W4296341524A5039378237 @default.
• W4296341524 hasAuthorship W4296341524A5043900419 @default.
• W4296341524 hasAuthorship W4296341524A5049761912 @default.
• W4296341524 hasAuthorship W4296341524A5071115514 @default.
• W4296341524 hasBestOaLocation W42963415241 @default.
• W4296341524 hasConcept C113278225 @default.
• W4296341524 hasConcept C126322002 @default.
• W4296341524 hasConcept C141071460 @default.
• W4296341524 hasConcept C146957229 @default.
• W4296341524 hasConcept C194828623 @default.
• W4296341524 hasConcept C2779609443 @default.
• W4296341524 hasConcept C2780014101 @default.
• W4296341524 hasConcept C2780920261 @default.
• W4296341524 hasConcept C2911091166 @default.
• W4296341524 hasConcept C535046627 @default.
• W4296341524 hasConcept C71924100 @default.
• W4296341524 hasConceptScore W4296341524C113278225 @default.
• W4296341524 hasConceptScore W4296341524C126322002 @default.
• W4296341524 hasConceptScore W4296341524C141071460 @default.
• W4296341524 hasConceptScore W4296341524C146957229 @default.
• W4296341524 hasConceptScore W4296341524C194828623 @default.
• W4296341524 hasConceptScore W4296341524C2779609443 @default.
• W4296341524 hasConceptScore W4296341524C2780014101 @default.
• W4296341524 hasConceptScore W4296341524C2780920261 @default.
• W4296341524 hasConceptScore W4296341524C2911091166 @default.
• W4296341524 hasConceptScore W4296341524C535046627 @default.
• W4296341524 hasConceptScore W4296341524C71924100 @default.
• W4296341524 hasIssue "9S" @default.
• W4296341524 hasLocation W42963415241 @default.
• W4296341524 hasLocation W42963415242 @default.
• W4296341524 hasOpenAccess W4296341524 @default.
• W4296341524 hasPrimaryLocation W42963415241 @default.
• W4296341524 hasRelatedWork W2009826220 @default.
• W4296341524 hasRelatedWork W2077379161 @default.
• W4296341524 hasRelatedWork W2233914793 @default.
• W4296341524 hasRelatedWork W2322484421 @default.
• W4296341524 hasRelatedWork W2387637538 @default.
• W4296341524 hasRelatedWork W2466373449 @default.
• W4296341524 hasRelatedWork W2579896967 @default.
• W4296341524 hasRelatedWork W2777165984 @default.
• W4296341524 hasRelatedWork W3031985841 @default.
• W4296341524 hasRelatedWork W4233594613 @default.
• W4296341524 hasVolume "106" @default.
• W4296341524 isParatext "false" @default.
• W4296341524 isRetracted "false" @default.
• W4296341524 workType "article" @default.