FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296375622> ?p ?o ?g. }

• W4296375622 endingPage "e30232" @default.
• W4296375622 startingPage "e30232" @default.
• W4296375622 abstract "Biliary atresia (BA) is the most common cause of obstructive jaundice during the neonatal period. This study aimed to identify gene expression signature in BA. The datasets were obtained from the Gene Expression Omnibus database. Weighted gene co-expression network analysis identified a critical module associated with BA, whereas Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed the functions of the essential modules. The high-connectivity genes in the most relevant module constructed protein-protein interaction networks via the string website and Cytoscape software. Hub genes screened by lasso regression consisted of a disease classification model using the randomforest method. Receiver operating characteristic curves were used to assess models' sensitivity and specificity and the model was verified using the internal and external validation sets. Ten gene modules were constructed by WGCNA, of which the brown module had a strong positive correlation with BA, comprising 443 genes. Functional enrichment analysis revealed that module genes were mainly involved in biological processes, such as extracellular matrix organization, cell adhesion, inflammatory response, and the Notch pathway (P < .001), whereas these genes were involved in the metabolic pathways and cell adhesion molecules (P < .001). Thirty-nine high-connectivity genes in the brown module constructed protein-protein interaction networks. keratin 7 (KRT7) and C-X-C motif chemokine ligand 8 (CXCL8) were used to construct a diagnostic model that had an accuracy of 93.6% and the area under the receiver operating curves for the model was 0.93. The study provided insight into the signature of gene expression and possible pathogenesis of BA; furthermore, it identified that the combination of KRT7 and CXCL8 could be a potential diagnostic model for BA." @default.
• W4296375622 created "2022-09-20" @default.
• W4296375622 creator A5003481631 @default.
• W4296375622 creator A5025098415 @default.
• W4296375622 creator A5035367988 @default.
• W4296375622 creator A5070756898 @default.
• W4296375622 date "2022-09-16" @default.
• W4296375622 modified "2023-09-26" @default.
• W4296375622 title "Identification of signature of gene expression in biliary atresia using weighted gene co-expression network analysis" @default.
• W4296375622 cites W1966327575 @default.
• W4296375622 cites W1973694149 @default.
• W4296375622 cites W1974082873 @default.
• W4296375622 cites W1978691787 @default.
• W4296375622 cites W1981570048 @default.
• W4296375622 cites W1986155425 @default.
• W4296375622 cites W2006617902 @default.
• W4296375622 cites W2007736073 @default.
• W4296375622 cites W2008116498 @default.
• W4296375622 cites W2013099264 @default.
• W4296375622 cites W2026482022 @default.
• W4296375622 cites W2031688735 @default.
• W4296375622 cites W2060705109 @default.
• W4296375622 cites W2062296104 @default.
• W4296375622 cites W2063957319 @default.
• W4296375622 cites W2071618738 @default.
• W4296375622 cites W2079852562 @default.
• W4296375622 cites W2098411129 @default.
• W4296375622 cites W2098572365 @default.
• W4296375622 cites W2112006422 @default.
• W4296375622 cites W2123377807 @default.
• W4296375622 cites W2134867677 @default.
• W4296375622 cites W2148708580 @default.
• W4296375622 cites W2168469162 @default.
• W4296375622 cites W2170297639 @default.
• W4296375622 cites W2214176511 @default.
• W4296375622 cites W2315476637 @default.
• W4296375622 cites W2334232097 @default.
• W4296375622 cites W2347194146 @default.
• W4296375622 cites W2404906506 @default.
• W4296375622 cites W2475290756 @default.
• W4296375622 cites W2480517066 @default.
• W4296375622 cites W2537083947 @default.
• W4296375622 cites W2572069669 @default.
• W4296375622 cites W2751516044 @default.
• W4296375622 cites W2766272439 @default.
• W4296375622 cites W2890324251 @default.
• W4296375622 cites W2890548773 @default.
• W4296375622 cites W2890949205 @default.
• W4296375622 cites W2973357647 @default.
• W4296375622 cites W2979296967 @default.
• W4296375622 cites W3011593540 @default.
• W4296375622 cites W3034706172 @default.
• W4296375622 cites W3043868530 @default.
• W4296375622 cites W3084804843 @default.
• W4296375622 cites W3202551161 @default.
• W4296375622 cites W4229837924 @default.
• W4296375622 cites W4245148160 @default.
• W4296375622 cites W4294541781 @default.
• W4296375622 doi "https://doi.org/10.1097/md.0000000000030232" @default.
• W4296375622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36123893" @default.
• W4296375622 hasPublicationYear "2022" @default.
• W4296375622 type Work @default.
• W4296375622 citedByCount "0" @default.
• W4296375622 crossrefType "journal-article" @default.
• W4296375622 hasAuthorship W4296375622A5003481631 @default.
• W4296375622 hasAuthorship W4296375622A5025098415 @default.
• W4296375622 hasAuthorship W4296375622A5035367988 @default.
• W4296375622 hasAuthorship W4296375622A5070756898 @default.
• W4296375622 hasBestOaLocation W42963756221 @default.
• W4296375622 hasConcept C104317684 @default.
• W4296375622 hasConcept C126322002 @default.
• W4296375622 hasConcept C141071460 @default.
• W4296375622 hasConcept C150194340 @default.
• W4296375622 hasConcept C152724338 @default.
• W4296375622 hasConcept C18431079 @default.
• W4296375622 hasConcept C2778022302 @default.
• W4296375622 hasConcept C2779243279 @default.
• W4296375622 hasConcept C2779609443 @default.
• W4296375622 hasConcept C2911091166 @default.
• W4296375622 hasConcept C2987395477 @default.
• W4296375622 hasConcept C54355233 @default.
• W4296375622 hasConcept C58471807 @default.
• W4296375622 hasConcept C60644358 @default.
• W4296375622 hasConcept C70721500 @default.
• W4296375622 hasConcept C71924100 @default.
• W4296375622 hasConcept C86803240 @default.
• W4296375622 hasConceptScore W4296375622C104317684 @default.
• W4296375622 hasConceptScore W4296375622C126322002 @default.
• W4296375622 hasConceptScore W4296375622C141071460 @default.
• W4296375622 hasConceptScore W4296375622C150194340 @default.
• W4296375622 hasConceptScore W4296375622C152724338 @default.
• W4296375622 hasConceptScore W4296375622C18431079 @default.
• W4296375622 hasConceptScore W4296375622C2778022302 @default.
• W4296375622 hasConceptScore W4296375622C2779243279 @default.
• W4296375622 hasConceptScore W4296375622C2779609443 @default.
• W4296375622 hasConceptScore W4296375622C2911091166 @default.
• W4296375622 hasConceptScore W4296375622C2987395477 @default.
• W4296375622 hasConceptScore W4296375622C54355233 @default.

• next