Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296382639> ?p ?o ?g. }
- W4296382639 abstract "Abstract Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a more refined appreciation of the TIME in childhood cancers, rather than a reliance on commonly used biomarkers such as tumour mutation burden (TMB), neoantigen load and PD-L1 expression, is an essential prerequisite for improved immunotherapies in childhood solid cancers. We combined immunohistochemistry (IHC) and molecular profiling to develop an alternative, expression-based signature associated with CD8 + T-cell infiltration of the TIME in high-risk paediatric tumours. Using this novel 15-gene immune signature, Immune Paediatric Signature Score (IPASS), we estimate up to 31% of high-risk cancers harbour infiltrating T-cells. Our data provides new insights into the variable immune-suppressive mechanisms dampening responses in paediatric solid cancers. Effective immune-based interventions in high-risk paediatric cancer will require individualised analysis of the TIME." @default.
- W4296382639 created "2022-09-20" @default.
- W4296382639 creator A5005290498 @default.
- W4296382639 creator A5006887078 @default.
- W4296382639 creator A5007383393 @default.
- W4296382639 creator A5013876134 @default.
- W4296382639 creator A5015202246 @default.
- W4296382639 creator A5015732671 @default.
- W4296382639 creator A5019958748 @default.
- W4296382639 creator A5021443834 @default.
- W4296382639 creator A5025488243 @default.
- W4296382639 creator A5027426012 @default.
- W4296382639 creator A5029940736 @default.
- W4296382639 creator A5035808651 @default.
- W4296382639 creator A5036914684 @default.
- W4296382639 creator A5039295944 @default.
- W4296382639 creator A5040951043 @default.
- W4296382639 creator A5042255572 @default.
- W4296382639 creator A5043292171 @default.
- W4296382639 creator A5044010440 @default.
- W4296382639 creator A5044706959 @default.
- W4296382639 creator A5045001483 @default.
- W4296382639 creator A5046135979 @default.
- W4296382639 creator A5046321083 @default.
- W4296382639 creator A5048989983 @default.
- W4296382639 creator A5050455996 @default.
- W4296382639 creator A5050816601 @default.
- W4296382639 creator A5053561462 @default.
- W4296382639 creator A5053765299 @default.
- W4296382639 creator A5054642128 @default.
- W4296382639 creator A5056614468 @default.
- W4296382639 creator A5060279277 @default.
- W4296382639 creator A5062086264 @default.
- W4296382639 creator A5062700207 @default.
- W4296382639 creator A5064696468 @default.
- W4296382639 creator A5065335349 @default.
- W4296382639 creator A5065759041 @default.
- W4296382639 creator A5067500670 @default.
- W4296382639 creator A5070139120 @default.
- W4296382639 creator A5072009574 @default.
- W4296382639 creator A5073715340 @default.
- W4296382639 creator A5078090612 @default.
- W4296382639 creator A5081047170 @default.
- W4296382639 creator A5082316302 @default.
- W4296382639 creator A5086201555 @default.
- W4296382639 creator A5089500575 @default.
- W4296382639 date "2022-09-19" @default.
- W4296382639 modified "2023-10-05" @default.
- W4296382639 title "A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer" @default.
- W4296382639 cites W1548780175 @default.
- W4296382639 cites W1824670638 @default.
- W4296382639 cites W1931737153 @default.
- W4296382639 cites W1973751980 @default.
- W4296382639 cites W1985987855 @default.
- W4296382639 cites W1996868603 @default.
- W4296382639 cites W2000305183 @default.
- W4296382639 cites W2011458181 @default.
- W4296382639 cites W2023352956 @default.
- W4296382639 cites W2048073154 @default.
- W4296382639 cites W2084659308 @default.
- W4296382639 cites W2089041106 @default.
- W4296382639 cites W2127303484 @default.
- W4296382639 cites W2140235037 @default.
- W4296382639 cites W2150056019 @default.
- W4296382639 cites W2162856391 @default.
- W4296382639 cites W2168401979 @default.
- W4296382639 cites W2171942860 @default.
- W4296382639 cites W2201306698 @default.
- W4296382639 cites W2256496883 @default.
- W4296382639 cites W2346121781 @default.
- W4296382639 cites W2411861063 @default.
- W4296382639 cites W2533508881 @default.
- W4296382639 cites W2561926137 @default.
- W4296382639 cites W2592811885 @default.
- W4296382639 cites W2599073119 @default.
- W4296382639 cites W2610371878 @default.
- W4296382639 cites W2655262992 @default.
- W4296382639 cites W2676309654 @default.
- W4296382639 cites W2753906509 @default.
- W4296382639 cites W2783127976 @default.
- W4296382639 cites W2789869568 @default.
- W4296382639 cites W2807729510 @default.
- W4296382639 cites W2809092757 @default.
- W4296382639 cites W2809205318 @default.
- W4296382639 cites W2810219671 @default.
- W4296382639 cites W2888557095 @default.
- W4296382639 cites W2897815318 @default.
- W4296382639 cites W2904444972 @default.
- W4296382639 cites W2907564726 @default.
- W4296382639 cites W2908847646 @default.
- W4296382639 cites W2942610007 @default.
- W4296382639 cites W2947554843 @default.
- W4296382639 cites W2951675934 @default.
- W4296382639 cites W2952065098 @default.
- W4296382639 cites W2952481429 @default.
- W4296382639 cites W2982017357 @default.
- W4296382639 cites W2988644538 @default.
- W4296382639 cites W2990849834 @default.
- W4296382639 cites W2992921938 @default.
- W4296382639 cites W3009083935 @default.