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- W4296390228 abstract "The fundamental commonality across pharmacotherapies for the epilepsies is the modulation of neuronal excitability. This poses a clear challenge—patterned neuronal excitation is essential to normal function, thus disrupting this activity leads to side effects. Moreover, the efficacy of current pharmacotherapy remains incomplete despite decades of drug development. Approaches that allow for the selective targeting of critical populations of cells and particular pathways in the brain have the potential to both avoid side effects and improve efficacy. Chemogenetic methods, which combine the selective expression of designer receptors with designer drugs, have rapidly grown in use in the neurosciences, including in epilepsy. This review will briefly highlight the history of chemogenetics, their applications to date in epilepsy, and the potential (and potential hurdles to overcome) for future translation." @default.
- W4296390228 created "2022-09-20" @default.
- W4296390228 creator A5036232159 @default.
- W4296390228 date "2022-09-01" @default.
- W4296390228 modified "2023-10-16" @default.
- W4296390228 title "Seizing Control of Neuronal Activity: Chemogenetic Applications in Epilepsy" @default.
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- W4296390228 doi "https://doi.org/10.1177/15357597221120348" @default.
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