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• W4296430505 abstract "<h3>Aim</h3> For patients with failing grafts, liver re-transplantation represents an opportunity to improve morbidity and mortality. However, some patients do not survive to receive this opportunity. Through reviewing outcomes in a regraft population in a tertiary liver unit, we aimed to establish factors which may be associated with a suboptimal outcome. <h3>Method</h3> In our liver transplant (LT) unit, all assessments (ax) for regraft conducted between 2017 and 2020 were identified from a transplant database. Hospital records were interrogated for the following data: indication for index LT, reason for regraft, time to complete the ax and present at the LT multidisciplinary team meeting (MDT), MDT outcome and individual patient outcome. <h3>Results</h3> 48 ax were completed, of which 23 were transplanted, 12 were not listed,12 died during the ax period. For those transplanted (male 65%), the average age at regraft ax was 43 years (UKELD 57, MELD 18). 12 (52%) had been undergone first transplant for immune mediated liver disease and 70% were being reassessed for disease recurrence or chronic rejection. Time from reassessment referral to first MDT was 18.7 days and listing for LT was recommended in 60%. Time from MDT discussion to listing was 14.5 days (range 1–60 days). In individuals that died prior to regraft, average age at regraft ax was 40 years (UKELD 59, MELD 23) with the 58% transplanted for rare liver diseases. Indication for regraft ax in the majority (42%) was biliary complications. Time from referral for reassessment and first MDT discussion was 20.4 days with only 3 being listed at that point. Average time to re-discussion was 42 days and time from MDT to listing was 25 days. <h3>Conclusion</h3> There was no significant difference in timings of the regraft assessment process for patients successfully undergoing re-transplantation compared to those with suboptimal outcomes during the ax. However, an indication for re-graft of biliary complications appeared to be associated with a poorer outcome in patients undergoing regraft assessment. Higher UKELD and MELD scores and increased intervals between MDT re-discussions in this cohort likely reflects the complexity of these patients. This may suggest that patients with biliary complications undergoing regraft assessment are at higher risk of deterioration." @default.
• W4296430505 created "2022-09-20" @default.
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• W4296430505 date "2022-09-01" @default.
• W4296430505 modified "2023-09-27" @default.
• W4296430505 title "OP34 Liver re-transplantation: understanding suboptimal outcomes during regraft reassessment" @default.
• W4296430505 doi "https://doi.org/10.1136/gutjnl-2022-basl.47" @default.
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