FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296466690> ?p ?o ?g. }

• W4296466690 endingPage "135" @default.
• W4296466690 startingPage "119" @default.
• W4296466690 abstract "The global population of people over the age of 65 is increasing and expected to reach 1.5 billion by 2050. While aging is associated with a number of chronic illnesses including dementia, the underlying contribution of alcohol misuse in the elderly is understudied. Long-term chronic alcohol misuse can lead to alcohol-associated liver disease, consisting of a spectrum of pathologies, including steatosis and cirrhosis; liver disease can be rapidly accelerated by non-resolving inflammation. Despite this knowledge, the mechanistic underpinnings of dysregulated host immunity and accelerated liver disease progression in the aged by alcohol is unknown. Alcohol misuse in the elderly is on the rise and aging is associated with progressive increases in pro-inflammatory cytokine production. The goals of the current study are to characterize bioactive lipid mediators of inflammation by making use of a murine model of ethanol-induced liver disease in 3-month-old and 20-month-old mice by quantitatively profiling selected oxylipins in liver, brain and plasma. Following chronic ethanol exposure, liver injury, steatosis, and senescence markers were robustly increased in aged mice compared to young adult mice. Expression of proinflammatory cytokines and lipid metabolizing enzymes were increased in liver by both age and ethanol feeding. Lipoxygenase-derived lipid metabolites 9- and 13-hydroxy-octadecadienoic acid and 15-hydroxyeicosatetraenoic acid were increased in liver and plasma in ethanol-fed aged mice and positively correlated with liver injury. In plasma, 9,10-dihydroxy-octadecenoic acid/epoxy-octadecenoic acid plasma ratios correlated with liver injury in ethanol-fed aged mice. Finally, 15-hydroxyeicosatetraenoic acid and 9,10-dihydroxy-octadecenoic acid positively correlated between liver and plasma. Importantly, leukotriene E4, 9,10-dihydroxy-octadecenoic acid and 15-hydroxyeicosatetraenoic acid increased lipid accumulation and ER stress in cultured AML12 hepatocytes. These data highlight the complexity of lipid metabolite networks but identify key mediators that may be used for diagnostic and prognostic markers in early stages of alcohol-related liver disease in patients of all ages." @default.
• W4296466690 created "2022-09-21" @default.
• W4296466690 creator A5009002659 @default.
• W4296466690 creator A5028357387 @default.
• W4296466690 creator A5032064580 @default.
• W4296466690 creator A5038597279 @default.
• W4296466690 creator A5075777572 @default.
• W4296466690 date "2023-03-01" @default.
• W4296466690 modified "2023-09-30" @default.
• W4296466690 title "Profiling the oxylipidome in aged mice after chronic ethanol feeding: Identifying lipid metabolites as drivers of hepatocyte stress" @default.
• W4296466690 cites W1066986691 @default.
• W4296466690 cites W1510294511 @default.
• W4296466690 cites W1519109490 @default.
• W4296466690 cites W1757383019 @default.
• W4296466690 cites W1894408948 @default.
• W4296466690 cites W1923917571 @default.
• W4296466690 cites W1978011510 @default.
• W4296466690 cites W1980048396 @default.
• W4296466690 cites W1987882040 @default.
• W4296466690 cites W1989332145 @default.
• W4296466690 cites W1992303064 @default.
• W4296466690 cites W1995289527 @default.
• W4296466690 cites W1996666118 @default.
• W4296466690 cites W1998323589 @default.
• W4296466690 cites W1998624589 @default.
• W4296466690 cites W2007123357 @default.
• W4296466690 cites W2007288510 @default.
• W4296466690 cites W2012508659 @default.
• W4296466690 cites W2028821112 @default.
• W4296466690 cites W2029970782 @default.
• W4296466690 cites W2036409621 @default.
• W4296466690 cites W2042709372 @default.
• W4296466690 cites W2050631259 @default.
• W4296466690 cites W2053542703 @default.
• W4296466690 cites W2060637877 @default.
• W4296466690 cites W2065721609 @default.
• W4296466690 cites W2066555499 @default.
• W4296466690 cites W2067740038 @default.
• W4296466690 cites W2075780954 @default.
• W4296466690 cites W2077858109 @default.
• W4296466690 cites W2090651132 @default.
• W4296466690 cites W2111187697 @default.
• W4296466690 cites W2114184154 @default.
• W4296466690 cites W2123420560 @default.
• W4296466690 cites W2131486343 @default.
• W4296466690 cites W2140116636 @default.
• W4296466690 cites W2144476483 @default.
• W4296466690 cites W2152331845 @default.
• W4296466690 cites W2152877666 @default.
• W4296466690 cites W2153021040 @default.
• W4296466690 cites W2153646880 @default.
• W4296466690 cites W2161526491 @default.
• W4296466690 cites W2162670203 @default.
• W4296466690 cites W2166021655 @default.
• W4296466690 cites W2171714447 @default.
• W4296466690 cites W2215279754 @default.
• W4296466690 cites W2287176981 @default.
• W4296466690 cites W2396452750 @default.
• W4296466690 cites W2409079155 @default.
• W4296466690 cites W2416122254 @default.
• W4296466690 cites W2556776430 @default.
• W4296466690 cites W2605568460 @default.
• W4296466690 cites W2750224350 @default.
• W4296466690 cites W2754166039 @default.
• W4296466690 cites W2789920657 @default.
• W4296466690 cites W2791354060 @default.
• W4296466690 cites W2794875758 @default.
• W4296466690 cites W2806599368 @default.
• W4296466690 cites W2884081989 @default.
• W4296466690 cites W2889846652 @default.
• W4296466690 cites W2890887034 @default.
• W4296466690 cites W2892624109 @default.
• W4296466690 cites W2903340170 @default.
• W4296466690 cites W2914280463 @default.
• W4296466690 cites W2944567704 @default.
• W4296466690 cites W2947953297 @default.
• W4296466690 cites W2962991401 @default.
• W4296466690 cites W2967638167 @default.
• W4296466690 cites W2975537434 @default.
• W4296466690 cites W3005408539 @default.
• W4296466690 cites W3010215457 @default.
• W4296466690 cites W3032141359 @default.
• W4296466690 cites W3036413078 @default.
• W4296466690 cites W3090476062 @default.
• W4296466690 cites W3120458719 @default.
• W4296466690 cites W3127043380 @default.
• W4296466690 cites W3127639819 @default.
• W4296466690 cites W3181781482 @default.
• W4296466690 cites W3199037729 @default.
• W4296466690 cites W3200424716 @default.
• W4296466690 cites W3209213173 @default.
• W4296466690 cites W4205759455 @default.
• W4296466690 cites W4220997889 @default.
• W4296466690 cites W4230119926 @default.
• W4296466690 cites W4290096308 @default.
• W4296466690 doi "https://doi.org/10.1016/j.alcohol.2022.08.012" @default.
• W4296466690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36150611" @default.
• W4296466690 hasPublicationYear "2023" @default.

• next