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- W4296467515 abstract "The role of microparticles (MPs) and cold in high altitude pulmonary hypertension (HAPH) remains unexplored. We investigated the impact of long-term cold exposure on the pulmonary circulation in lowlanders and high-altitude natives and the role of MPs. Pulmonary hemodynamics were evaluated using Doppler echocardiography at the end of the colder and warmer seasons. We further examined the miRNA content of MPs isolated from the study participants and studied their effects on human pulmonary artery smooth muscle (hPASMCs) and endothelial cells (hPAECs). Long-term exposure to cold environment was associated with an enhanced pulmonary artery pressure in highlanders. Plasma levels of CD62E-positive and CD68-positive MPs increased in response to cold in lowlanders and HAPH highlanders. The miRNA-210 expression contained in MPs differentially changed in response to cold in lowlanders and highlanders. MPs isolated from lowlanders and highlanders increased proliferation and reduced apoptosis of hPASMCs. Further, MPs isolated from warm-exposed HAPH highlanders and cold-exposed highlanders exerted the most pronounced effects on VEGF expression in hPAECs. We demonstrated that prolonged exposure to cold is associated with elevated pulmonary artery pressures, which are most pronounced in high-altitude residents. Further, the numbers of circulating MPs are differentially increased in lowlanders and HAPH highlanders during the colder season." @default.
- W4296467515 created "2022-09-21" @default.
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- W4296467515 date "2022-09-20" @default.
- W4296467515 modified "2023-09-30" @default.
- W4296467515 title "Circulating Microparticles Are Differentially Increased in Lowlanders and Highlanders with High Altitude Induced Pulmonary Hypertension during the Cold Season" @default.
- W4296467515 cites W1529998901 @default.
- W4296467515 cites W1674139320 @default.
- W4296467515 cites W1964185318 @default.
- W4296467515 cites W1966311575 @default.
- W4296467515 cites W1975658126 @default.
- W4296467515 cites W1982296602 @default.
- W4296467515 cites W1983763042 @default.
- W4296467515 cites W1985738981 @default.
- W4296467515 cites W1991416126 @default.
- W4296467515 cites W2003886164 @default.
- W4296467515 cites W2012644815 @default.
- W4296467515 cites W2018721873 @default.
- W4296467515 cites W2022130519 @default.
- W4296467515 cites W2026429147 @default.
- W4296467515 cites W2040308532 @default.
- W4296467515 cites W2049604140 @default.
- W4296467515 cites W2051152628 @default.
- W4296467515 cites W2057657670 @default.
- W4296467515 cites W2071818649 @default.
- W4296467515 cites W2073738635 @default.
- W4296467515 cites W2080350120 @default.
- W4296467515 cites W2080833605 @default.
- W4296467515 cites W2086891360 @default.
- W4296467515 cites W2099426430 @default.
- W4296467515 cites W2100392205 @default.
- W4296467515 cites W2100927341 @default.
- W4296467515 cites W2104161408 @default.
- W4296467515 cites W2104584146 @default.
- W4296467515 cites W2107340529 @default.
- W4296467515 cites W2108601588 @default.
- W4296467515 cites W2109200395 @default.
- W4296467515 cites W2111686577 @default.
- W4296467515 cites W2116000203 @default.
- W4296467515 cites W2119881460 @default.
- W4296467515 cites W2126601545 @default.
- W4296467515 cites W2133533373 @default.
- W4296467515 cites W2149641297 @default.
- W4296467515 cites W2151339427 @default.
- W4296467515 cites W2153982586 @default.
- W4296467515 cites W2284003505 @default.
- W4296467515 cites W2292565922 @default.
- W4296467515 cites W2328481462 @default.
- W4296467515 cites W2337030559 @default.
- W4296467515 cites W2343189502 @default.
- W4296467515 cites W2441368693 @default.
- W4296467515 cites W2522353298 @default.
- W4296467515 cites W2527681716 @default.
- W4296467515 cites W2528453571 @default.
- W4296467515 cites W2552541548 @default.
- W4296467515 cites W2559007131 @default.
- W4296467515 cites W2584358852 @default.
- W4296467515 cites W2597560141 @default.
- W4296467515 cites W2604078889 @default.
- W4296467515 cites W2626585407 @default.
- W4296467515 cites W2762219442 @default.
- W4296467515 cites W2795178293 @default.
- W4296467515 cites W2803249542 @default.
- W4296467515 cites W2809566874 @default.
- W4296467515 cites W2896772915 @default.
- W4296467515 cites W2897481801 @default.
- W4296467515 cites W2901586278 @default.
- W4296467515 cites W2913216057 @default.
- W4296467515 cites W2954949129 @default.
- W4296467515 cites W2970206442 @default.
- W4296467515 cites W2982653531 @default.
- W4296467515 cites W3011411797 @default.