FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296473013> ?p ?o ?g. }

• W4296473013 abstract "Oral mucositis is a painful inflammatory response that can lead to infection, cachexia, and therapy termination. This immune-related adverse event (IRAE) has been well documented within the newly developing field of immunotherapy. This case series presents three patients, aged 73 to 81 years, who were undergoing treatment with programmed death-1 (PD-1) immunotherapy for cancer; each patient developed grade III mucositis, one after the fourth cycle and two after the seventh. All three patients had no prior history of oral pathology, yet each patient reported ulcerated and inflamed oral mucosa that was swollen and painful. These lesions involved various locations within the oral cavity and caused irritation to the point of dysphagia and odynophagia. Conservative treatments such as oral anesthetic and mouthwashes with antimicrobial properties had minimal effects. Each patient thereafter was started on systemic glucocorticoids in addition to the local treatments. The initiation of a systemic treatment resulted in a resolution of the oral lesions allowing each patient the option to return to their prior immunotherapy. Mucositis is uncommon and has no standardized treatment. This case series emphasizes the debilitative result of immunotherapy-induced mucositis and illustrates the need for systemic glucocorticoids. While conservative treatments such as oral mouthwashes can be effective in treating the symptoms of mucositis, the initiation of high-dose steroids with a prolonged taper has been shown to treat the condition at its source. Early recognition of mucositis with prompt initiation of steroids has proven to be the effective mainstay treatment to relieve mucositis while limiting pauses in cancer treatment." @default.
• W4296473013 created "2022-09-21" @default.
• W4296473013 creator A5002123419 @default.
• W4296473013 creator A5010246604 @default.
• W4296473013 creator A5016600727 @default.
• W4296473013 creator A5025013482 @default.
• W4296473013 creator A5026359252 @default.
• W4296473013 creator A5033001790 @default.
• W4296473013 creator A5070394464 @default.
• W4296473013 date "2022-09-20" @default.
• W4296473013 modified "2023-10-04" @default.
• W4296473013 title "A Therapy-Terminating Event: Programmed Death-1 Inhibitor-Induced Mucositis" @default.
• W4296473013 cites W1479969397 @default.
• W4296473013 cites W1971881051 @default.
• W4296473013 cites W1978454448 @default.
• W4296473013 cites W1990177213 @default.
• W4296473013 cites W1990675339 @default.
• W4296473013 cites W2010121426 @default.
• W4296473013 cites W2035838265 @default.
• W4296473013 cites W2094052190 @default.
• W4296473013 cites W2095826876 @default.
• W4296473013 cites W2118982164 @default.
• W4296473013 cites W2150048477 @default.
• W4296473013 cites W2152470413 @default.
• W4296473013 cites W2160834915 @default.
• W4296473013 cites W2161550811 @default.
• W4296473013 cites W2169586708 @default.
• W4296473013 cites W2469222194 @default.
• W4296473013 cites W2550419061 @default.
• W4296473013 cites W2560367415 @default.
• W4296473013 cites W2572174216 @default.
• W4296473013 cites W2583586879 @default.
• W4296473013 cites W2605157312 @default.
• W4296473013 cites W2762554941 @default.
• W4296473013 cites W2765103483 @default.
• W4296473013 cites W3092643048 @default.
• W4296473013 cites W3143804789 @default.
• W4296473013 doi "https://doi.org/10.7759/cureus.29377" @default.
• W4296473013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36304369" @default.
• W4296473013 hasPublicationYear "2022" @default.
• W4296473013 type Work @default.
• W4296473013 citedByCount "0" @default.
• W4296473013 crossrefType "journal-article" @default.
• W4296473013 hasAuthorship W4296473013A5002123419 @default.
• W4296473013 hasAuthorship W4296473013A5010246604 @default.
• W4296473013 hasAuthorship W4296473013A5016600727 @default.
• W4296473013 hasAuthorship W4296473013A5025013482 @default.
• W4296473013 hasAuthorship W4296473013A5026359252 @default.
• W4296473013 hasAuthorship W4296473013A5033001790 @default.
• W4296473013 hasAuthorship W4296473013A5070394464 @default.
• W4296473013 hasBestOaLocation W42964730131 @default.
• W4296473013 hasConcept C121608353 @default.
• W4296473013 hasConcept C126322002 @default.
• W4296473013 hasConcept C141071460 @default.
• W4296473013 hasConcept C142724271 @default.
• W4296473013 hasConcept C16005928 @default.
• W4296473013 hasConcept C197934379 @default.
• W4296473013 hasConcept C2776694085 @default.
• W4296473013 hasConcept C2776980227 @default.
• W4296473013 hasConcept C2777701055 @default.
• W4296473013 hasConcept C2778496288 @default.
• W4296473013 hasConcept C2779409057 @default.
• W4296473013 hasConcept C2780596822 @default.
• W4296473013 hasConcept C71924100 @default.
• W4296473013 hasConceptScore W4296473013C121608353 @default.
• W4296473013 hasConceptScore W4296473013C126322002 @default.
• W4296473013 hasConceptScore W4296473013C141071460 @default.
• W4296473013 hasConceptScore W4296473013C142724271 @default.
• W4296473013 hasConceptScore W4296473013C16005928 @default.
• W4296473013 hasConceptScore W4296473013C197934379 @default.
• W4296473013 hasConceptScore W4296473013C2776694085 @default.
• W4296473013 hasConceptScore W4296473013C2776980227 @default.
• W4296473013 hasConceptScore W4296473013C2777701055 @default.
• W4296473013 hasConceptScore W4296473013C2778496288 @default.
• W4296473013 hasConceptScore W4296473013C2779409057 @default.
• W4296473013 hasConceptScore W4296473013C2780596822 @default.
• W4296473013 hasConceptScore W4296473013C71924100 @default.
• W4296473013 hasLocation W42964730131 @default.
• W4296473013 hasLocation W42964730132 @default.
• W4296473013 hasLocation W42964730133 @default.
• W4296473013 hasOpenAccess W4296473013 @default.
• W4296473013 hasPrimaryLocation W42964730131 @default.
• W4296473013 hasRelatedWork W2003938723 @default.
• W4296473013 hasRelatedWork W2047967234 @default.
• W4296473013 hasRelatedWork W2110228884 @default.
• W4296473013 hasRelatedWork W2145438024 @default.
• W4296473013 hasRelatedWork W2439875401 @default.
• W4296473013 hasRelatedWork W2743648883 @default.
• W4296473013 hasRelatedWork W3011587781 @default.
• W4296473013 hasRelatedWork W378165227 @default.
• W4296473013 hasRelatedWork W4296473013 @default.
• W4296473013 hasRelatedWork W4385420628 @default.
• W4296473013 isParatext "false" @default.
• W4296473013 isRetracted "false" @default.
• W4296473013 workType "article" @default.