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- W4296479400 abstract "Abstract S7.3 Emergent theories on pathogenic fungal dispersal around the globe, September 23, 2022, 10:30 AM - 12:00 PM Objectives Azole-resistant Aspergillus fumigatus isolates from the environment hamper the treatment of patients suffering from Aspergillus diseases due to cross-resistance with agricultural azoles. Previous work has suggested A. fumigatus likely gains resistance through environmental azole exposure in so-called hotspots. Methods We investigated A. fumigatus resistance at multi-environmental sites including the compost, strawberry, and potatoes, where farmers used azole fungicides for crop protection. Results On average 105 A. fumigatus CFU/g was recovered of which roughly half were itraconazole and tebuconazole resistant. Similar tandem repeat-mediated resistance mechanisms were found in colonies cultured from these environmental sites as reported in clinical azole-resistant isolates. Conclusions Our results suggest that not only azole-containing plant-waste material but also other agricultural crops can be hotspots for resistance selection in A. fumigatus and underscores the need to further investigate transmission routes." @default.
- W4296479400 created "2022-09-21" @default.
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- W4296479400 date "2022-09-01" @default.
- W4296479400 modified "2023-10-14" @default.
- W4296479400 title "S7.3d Environmental surveillance of <i>Aspergillus fumigatus</i> in Dutch agricultural crops" @default.
- W4296479400 doi "https://doi.org/10.1093/mmy/myac072.s7.3d" @default.
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