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- W4296481808 startingPage "11017" @default.
- W4296481808 abstract "Human cytomegalovirus (HCMV) is a significant source of disease for the immunosuppressed and immunonaive. The treatment of HCMV is made more problematic by viral latency, a lifecycle stage in which the virus reduces its own gene expression and produces no infectious virus. The most highly expressed viral gene during HCMV latency is the viral β2.7 long non-coding RNA. Although we have recently shown that the β2.7 lncRNA lowers levels of reactive oxygen species (ROS) during infection in monocytes, how this impacts latency is unclear. We now show that β2.7 is important for establishing and maintaining HCMV latency by aiding the suppression of viral lytic gene expression and that this is directly related to its ability to quench reactive oxygen species (ROS). Consistent with this, we also find that exogenous inducers of ROS cause reactivation of latent HCMV. These effects can be compensated by treatment with an antioxidant to lower ROS levels. Finally, we show that ROS-mediated reactivation is independent of myeloid differentiation, but instead relies on NF-κB activation. Altogether, these results reveal a novel factor that is central to the complex process that underpins HCMV latency. These findings may be of particular relevance in the transplant setting, in which transplanted tissue/organs are subject to very high ROS levels, and HCMV reactivation poses a significant threat." @default.
- W4296481808 created "2022-09-21" @default.
- W4296481808 creator A5012950769 @default.
- W4296481808 creator A5054901372 @default.
- W4296481808 date "2022-09-20" @default.
- W4296481808 modified "2023-09-25" @default.
- W4296481808 title "The Human Cytomegalovirus β2.7 Long Non-Coding RNA Prevents Induction of Reactive Oxygen Species to Maintain Viral Gene Silencing during Latency" @default.
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- W4296481808 doi "https://doi.org/10.3390/ijms231911017" @default.
- W4296481808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36232315" @default.
- W4296481808 hasPublicationYear "2022" @default.
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