Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296483951> ?p ?o ?g. }
- W4296483951 abstract "Insulin and insulin-like growth factor 1 (IGF1) signaling is transduced by insulin receptor substrate 1 (IRS1) and IRS2. To elucidate physiological and redundant roles of insulin and IGF1 signaling in adult hearts, we generated mice with inducible cardiomyocyte-specific deletion of insulin and IGF1 receptors or IRS1 and IRS2. Both models developed dilated cardiomyopathy, and most mice died by 8 weeks post-gene deletion. Heart failure was characterized by cardiomyocyte loss and disarray, increased proapoptotic signaling, and increased autophagy. Suppression of autophagy by activating mTOR signaling did not prevent heart failure. Transcriptional profiling revealed reduced serum response factor (SRF) transcriptional activity and decreased mRNA levels of genes encoding sarcomere and gap junction proteins as early as 3 days post-gene deletion, in concert with ultrastructural evidence of sarcomere disruption and intercalated discs within 1 week after gene deletion. These data confirm conserved roles for constitutive insulin and IGF1 signaling in suppressing autophagic and apoptotic signaling in the adult heart. The present study also identifies an unexpected role for insulin and IGF1 signaling in regulating an SRF-mediated transcriptional program, which maintains expression of genes encoding proteins that support sarcomere integrity in the adult heart, reduction of which results in rapid development of heart failure." @default.
- W4296483951 created "2022-09-21" @default.
- W4296483951 creator A5002350238 @default.
- W4296483951 creator A5011650333 @default.
- W4296483951 creator A5016118935 @default.
- W4296483951 creator A5022475772 @default.
- W4296483951 creator A5033677251 @default.
- W4296483951 creator A5043829844 @default.
- W4296483951 creator A5059594064 @default.
- W4296483951 creator A5060464452 @default.
- W4296483951 creator A5063731996 @default.
- W4296483951 creator A5071079758 @default.
- W4296483951 creator A5084850190 @default.
- W4296483951 creator A5087936952 @default.
- W4296483951 creator A5088133509 @default.
- W4296483951 date "2022-10-01" @default.
- W4296483951 modified "2023-09-26" @default.
- W4296483951 title "Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart" @default.
- W4296483951 cites W1483822327 @default.
- W4296483951 cites W1537487587 @default.
- W4296483951 cites W1634601902 @default.
- W4296483951 cites W1697523131 @default.
- W4296483951 cites W1964592723 @default.
- W4296483951 cites W1966373813 @default.
- W4296483951 cites W1968878147 @default.
- W4296483951 cites W1972850718 @default.
- W4296483951 cites W1972944323 @default.
- W4296483951 cites W1988555532 @default.
- W4296483951 cites W1989324173 @default.
- W4296483951 cites W1996745492 @default.
- W4296483951 cites W2000643542 @default.
- W4296483951 cites W2001962749 @default.
- W4296483951 cites W2004101138 @default.
- W4296483951 cites W2007821852 @default.
- W4296483951 cites W2022183896 @default.
- W4296483951 cites W2022188551 @default.
- W4296483951 cites W2024054858 @default.
- W4296483951 cites W2033429522 @default.
- W4296483951 cites W2035968737 @default.
- W4296483951 cites W2038472472 @default.
- W4296483951 cites W2046419063 @default.
- W4296483951 cites W2047860205 @default.
- W4296483951 cites W2053127486 @default.
- W4296483951 cites W2057993677 @default.
- W4296483951 cites W2066195344 @default.
- W4296483951 cites W2071424594 @default.
- W4296483951 cites W2080204105 @default.
- W4296483951 cites W2081899223 @default.
- W4296483951 cites W2083920985 @default.
- W4296483951 cites W2084697100 @default.
- W4296483951 cites W2087351164 @default.
- W4296483951 cites W2096628719 @default.
- W4296483951 cites W2099704543 @default.
- W4296483951 cites W2099891423 @default.
- W4296483951 cites W2106592406 @default.
- W4296483951 cites W2114170344 @default.
- W4296483951 cites W2116960319 @default.
- W4296483951 cites W2121169322 @default.
- W4296483951 cites W2121989806 @default.
- W4296483951 cites W2122144011 @default.
- W4296483951 cites W2123434632 @default.
- W4296483951 cites W2125708399 @default.
- W4296483951 cites W2125951597 @default.
- W4296483951 cites W2127620022 @default.
- W4296483951 cites W2128536736 @default.
- W4296483951 cites W2130410032 @default.
- W4296483951 cites W2131845382 @default.
- W4296483951 cites W2133615731 @default.
- W4296483951 cites W2139815734 @default.
- W4296483951 cites W2140724737 @default.
- W4296483951 cites W2140725006 @default.
- W4296483951 cites W2142781702 @default.
- W4296483951 cites W2153616813 @default.
- W4296483951 cites W2154993940 @default.
- W4296483951 cites W2326849778 @default.
- W4296483951 cites W2793297943 @default.
- W4296483951 cites W2809656898 @default.
- W4296483951 cites W3013264343 @default.
- W4296483951 cites W4236765824 @default.
- W4296483951 cites W4280532876 @default.
- W4296483951 cites W6736524 @default.
- W4296483951 doi "https://doi.org/10.1128/mcb.00163-22" @default.
- W4296483951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36125265" @default.
- W4296483951 hasPublicationYear "2022" @default.
- W4296483951 type Work @default.
- W4296483951 citedByCount "2" @default.
- W4296483951 countsByYear W42964839512023 @default.
- W4296483951 crossrefType "journal-article" @default.
- W4296483951 hasAuthorship W4296483951A5002350238 @default.
- W4296483951 hasAuthorship W4296483951A5011650333 @default.
- W4296483951 hasAuthorship W4296483951A5016118935 @default.
- W4296483951 hasAuthorship W4296483951A5022475772 @default.
- W4296483951 hasAuthorship W4296483951A5033677251 @default.
- W4296483951 hasAuthorship W4296483951A5043829844 @default.
- W4296483951 hasAuthorship W4296483951A5059594064 @default.
- W4296483951 hasAuthorship W4296483951A5060464452 @default.
- W4296483951 hasAuthorship W4296483951A5063731996 @default.
- W4296483951 hasAuthorship W4296483951A5071079758 @default.
- W4296483951 hasAuthorship W4296483951A5084850190 @default.
- W4296483951 hasAuthorship W4296483951A5087936952 @default.