Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296493510> ?p ?o ?g. }
- W4296493510 endingPage "e0269671" @default.
- W4296493510 startingPage "e0269671" @default.
- W4296493510 abstract "Pathological low birth weight due to fetal growth restriction (FGR) is an important predictor of adverse obstetric and neonatal outcomes. It is more common amongst native lowlanders when gestating in the hypoxic environment of high altitude, whilst populations who have resided at high altitude for many generations are relatively protected. Genetic study of pregnant populations at high altitude permits exploration of the role of hypoxia in FGR pathogenesis, and perhaps of FGR pathogenesis more broadly. We studied the umbilical cord blood DNA of 316 neonates born to pregnant women managed at the Sonam Norboo Memorial Hospital, Ladakh (altitude 3540m) between February 2017 and January 2019. Principal component, admixture and genome wide association studies (GWAS) were applied to dense single nucleotide polymorphism (SNP) genetic data, to explore ancestry and genetic predictors of low birth weight. Our findings support Tibetan ancestry in the Ladakhi population, with subsequent admixture with neighboring Indo-Aryan populations. Fetal growth protection was evident in Ladakhi neonates. Although no variants achieved genome wide significance, we observed nominal association of seven variants across genes (ZBTB38, ZFP36L2, HMGA2, CDKAL1, PLCG1) previously associated with birthweight." @default.
- W4296493510 created "2022-09-21" @default.
- W4296493510 creator A5013502928 @default.
- W4296493510 creator A5034213136 @default.
- W4296493510 creator A5036493579 @default.
- W4296493510 creator A5041098603 @default.
- W4296493510 creator A5042026444 @default.
- W4296493510 creator A5046282498 @default.
- W4296493510 creator A5053355056 @default.
- W4296493510 creator A5057742388 @default.
- W4296493510 creator A5065916946 @default.
- W4296493510 creator A5074063839 @default.
- W4296493510 creator A5080446938 @default.
- W4296493510 creator A5082555545 @default.
- W4296493510 creator A5087491954 @default.
- W4296493510 date "2022-09-20" @default.
- W4296493510 modified "2023-10-01" @default.
- W4296493510 title "Population history and genome wide association studies of birth weight in a native high altitude Ladakhi population" @default.
- W4296493510 cites W1523312042 @default.
- W4296493510 cites W1856439705 @default.
- W4296493510 cites W1974586776 @default.
- W4296493510 cites W2009965116 @default.
- W4296493510 cites W2015568175 @default.
- W4296493510 cites W2017421607 @default.
- W4296493510 cites W2026591397 @default.
- W4296493510 cites W2031792984 @default.
- W4296493510 cites W2032684959 @default.
- W4296493510 cites W2040516688 @default.
- W4296493510 cites W2042936342 @default.
- W4296493510 cites W2043365088 @default.
- W4296493510 cites W2047286107 @default.
- W4296493510 cites W2052092988 @default.
- W4296493510 cites W2062818316 @default.
- W4296493510 cites W2079973462 @default.
- W4296493510 cites W2080873675 @default.
- W4296493510 cites W2085656275 @default.
- W4296493510 cites W2097576041 @default.
- W4296493510 cites W2097968895 @default.
- W4296493510 cites W2099085143 @default.
- W4296493510 cites W2102213696 @default.
- W4296493510 cites W2112861264 @default.
- W4296493510 cites W2119444539 @default.
- W4296493510 cites W2140247198 @default.
- W4296493510 cites W2161633633 @default.
- W4296493510 cites W2166214412 @default.
- W4296493510 cites W2168704508 @default.
- W4296493510 cites W2510387549 @default.
- W4296493510 cites W2519262228 @default.
- W4296493510 cites W2573439428 @default.
- W4296493510 cites W2738493279 @default.
- W4296493510 cites W2790552383 @default.
- W4296493510 cites W2793911400 @default.
- W4296493510 cites W2804191551 @default.
- W4296493510 cites W2896958236 @default.
- W4296493510 cites W2901330346 @default.
- W4296493510 cites W2904806604 @default.
- W4296493510 cites W2949112115 @default.
- W4296493510 cites W2967687053 @default.
- W4296493510 cites W3110963439 @default.
- W4296493510 cites W3167050404 @default.
- W4296493510 doi "https://doi.org/10.1371/journal.pone.0269671" @default.
- W4296493510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36126061" @default.
- W4296493510 hasPublicationYear "2022" @default.
- W4296493510 type Work @default.
- W4296493510 citedByCount "1" @default.
- W4296493510 countsByYear W42964935102023 @default.
- W4296493510 crossrefType "journal-article" @default.
- W4296493510 hasAuthorship W4296493510A5013502928 @default.
- W4296493510 hasAuthorship W4296493510A5034213136 @default.
- W4296493510 hasAuthorship W4296493510A5036493579 @default.
- W4296493510 hasAuthorship W4296493510A5041098603 @default.
- W4296493510 hasAuthorship W4296493510A5042026444 @default.
- W4296493510 hasAuthorship W4296493510A5046282498 @default.
- W4296493510 hasAuthorship W4296493510A5053355056 @default.
- W4296493510 hasAuthorship W4296493510A5057742388 @default.
- W4296493510 hasAuthorship W4296493510A5065916946 @default.
- W4296493510 hasAuthorship W4296493510A5074063839 @default.
- W4296493510 hasAuthorship W4296493510A5080446938 @default.
- W4296493510 hasAuthorship W4296493510A5082555545 @default.
- W4296493510 hasAuthorship W4296493510A5087491954 @default.
- W4296493510 hasBestOaLocation W42964935101 @default.
- W4296493510 hasConcept C104317684 @default.
- W4296493510 hasConcept C105702510 @default.
- W4296493510 hasConcept C106208931 @default.
- W4296493510 hasConcept C135763542 @default.
- W4296493510 hasConcept C139275648 @default.
- W4296493510 hasConcept C153209595 @default.
- W4296493510 hasConcept C186413461 @default.
- W4296493510 hasConcept C2908647359 @default.
- W4296493510 hasConcept C42407357 @default.
- W4296493510 hasConcept C54355233 @default.
- W4296493510 hasConcept C71924100 @default.
- W4296493510 hasConcept C8240015 @default.
- W4296493510 hasConcept C86803240 @default.
- W4296493510 hasConcept C99454951 @default.
- W4296493510 hasConceptScore W4296493510C104317684 @default.
- W4296493510 hasConceptScore W4296493510C105702510 @default.
- W4296493510 hasConceptScore W4296493510C106208931 @default.