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- W4296527701 abstract "Clinical depression is a multifactorial disorder and one of the leading causes of disability worldwide. The alterations in tryptophan metabolism such as changes in the levels of serotonin, kynurenine, and kynurenine acid have been implicated in the etiology of depression for more than 50 years. In recent years, accumulated evidence has revealed that gut microbial communities, besides being essential players in various aspects of host physiology and brain functioning are also implicated in the etiology of depression, particularly through modulation of tryptophan metabolism. Therefore, the aim of this review is to summarize the evidence of the role of gut bacteria in disturbed tryptophan metabolism in depression. We summed up the effects of microbiota on serotonin, kynurenine, and indole pathway of tryptophan conversion relevant for understanding the pathogenesis of depressive behavior. Moreover, we reviewed data regarding the therapeutic effects of probiotics, particularly through the regulation of tryptophan metabolites. Taken together, these findings can open new possibilities for further improvement of treatments for depression based on the microbiota-mediated modulation of the tryptophan pathway." @default.
- W4296527701 created "2022-09-21" @default.
- W4296527701 creator A5013950070 @default.
- W4296527701 creator A5025210885 @default.
- W4296527701 creator A5054964625 @default.
- W4296527701 creator A5083992553 @default.
- W4296527701 date "2022-09-12" @default.
- W4296527701 modified "2023-10-17" @default.
- W4296527701 title "Tryptophan metabolites in depression: Modulation by gut microbiota" @default.
- W4296527701 cites W114145985 @default.
- W4296527701 cites W130054925 @default.
- W4296527701 cites W1519800783 @default.
- W4296527701 cites W1547937746 @default.
- W4296527701 cites W1665140791 @default.
- W4296527701 cites W1692825366 @default.
- W4296527701 cites W1764884642 @default.
- W4296527701 cites W1828538530 @default.
- W4296527701 cites W1833773432 @default.
- W4296527701 cites W1834981029 @default.
- W4296527701 cites W1861219352 @default.
- W4296527701 cites W1964187078 @default.
- W4296527701 cites W1965532359 @default.
- W4296527701 cites W1973172818 @default.
- W4296527701 cites W1976114760 @default.
- W4296527701 cites W1981500982 @default.
- W4296527701 cites W1985615482 @default.
- W4296527701 cites W1986333080 @default.
- W4296527701 cites W1989699877 @default.
- W4296527701 cites W1990454576 @default.
- W4296527701 cites W1992395370 @default.
- W4296527701 cites W1992533315 @default.
- W4296527701 cites W1992860227 @default.
- W4296527701 cites W1993516262 @default.
- W4296527701 cites W1994455271 @default.
- W4296527701 cites W1999356104 @default.
- W4296527701 cites W2000118200 @default.
- W4296527701 cites W2000644842 @default.
- W4296527701 cites W2003982930 @default.
- W4296527701 cites W2004331086 @default.
- W4296527701 cites W2005383727 @default.
- W4296527701 cites W2005776786 @default.
- W4296527701 cites W2008249034 @default.
- W4296527701 cites W2019558409 @default.
- W4296527701 cites W2023634568 @default.
- W4296527701 cites W2033386838 @default.
- W4296527701 cites W2036287976 @default.
- W4296527701 cites W2037457456 @default.
- W4296527701 cites W2039956056 @default.
- W4296527701 cites W2042731928 @default.
- W4296527701 cites W2043077656 @default.
- W4296527701 cites W2044216294 @default.
- W4296527701 cites W2047798386 @default.
- W4296527701 cites W2049821596 @default.
- W4296527701 cites W2050508296 @default.
- W4296527701 cites W2051353156 @default.
- W4296527701 cites W2053472601 @default.
- W4296527701 cites W2055623573 @default.
- W4296527701 cites W2055909204 @default.
- W4296527701 cites W2058331036 @default.
- W4296527701 cites W2059150405 @default.
- W4296527701 cites W2060050678 @default.
- W4296527701 cites W2060415968 @default.
- W4296527701 cites W2062815987 @default.
- W4296527701 cites W2063682731 @default.
- W4296527701 cites W2067909444 @default.
- W4296527701 cites W2068661217 @default.
- W4296527701 cites W2073145669 @default.
- W4296527701 cites W2073714219 @default.
- W4296527701 cites W2077425100 @default.
- W4296527701 cites W2083279903 @default.
- W4296527701 cites W2085139899 @default.
- W4296527701 cites W2085706434 @default.
- W4296527701 cites W2086208662 @default.
- W4296527701 cites W2086727869 @default.
- W4296527701 cites W2087146795 @default.
- W4296527701 cites W2092744841 @default.
- W4296527701 cites W2095028723 @default.
- W4296527701 cites W2096579248 @default.
- W4296527701 cites W2100230238 @default.
- W4296527701 cites W2104247936 @default.
- W4296527701 cites W2106623141 @default.
- W4296527701 cites W2106885532 @default.
- W4296527701 cites W2110985986 @default.
- W4296527701 cites W2115203342 @default.
- W4296527701 cites W2120052544 @default.
- W4296527701 cites W2120283081 @default.
- W4296527701 cites W2120306544 @default.
- W4296527701 cites W2120343652 @default.
- W4296527701 cites W2125984173 @default.
- W4296527701 cites W2137979078 @default.
- W4296527701 cites W2139904925 @default.
- W4296527701 cites W2142148369 @default.
- W4296527701 cites W2146758523 @default.
- W4296527701 cites W2151553159 @default.
- W4296527701 cites W2155897723 @default.
- W4296527701 cites W2158072789 @default.
- W4296527701 cites W2159202946 @default.
- W4296527701 cites W2162323969 @default.
- W4296527701 cites W2162624266 @default.
- W4296527701 cites W2164283010 @default.