FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296564689> ?p ?o ?g. }

• W4296564689 endingPage "5295" @default.
• W4296564689 startingPage "5287" @default.
• W4296564689 abstract "Synthetic lethality (SL) is an emerging therapeutic paradigm in cancer. We introduced a different approach to prioritize SL gene pairs through literature mining and RAS-mutant high-throughput screening (HTS) data. We matched essential genes from text-mining and mutant genes from the COSMIC and CCLE HTS datasets to build a prediction model of SL gene pairs. CCLE gene expression data were used to enrich the essential-mutant SL gene pairs using Spearman’s correlation coefficient and literature mining. In total, 223 essential trigger terms were extracted and ranked. The threshold of the essential gene score (Sg) was set to 10. We identified 586 genes essential for the SL prediction model of colon cancer. Seven essential RAS-mutant SL gene pairs were identified in our model, including CD82-KRAS/NRAS, PEBP1-NRAS, MT-CO2-HRAS, IFI27-NRAS/KRAS, and SUMO1-HRAS gene pairs. Using RAS-mutant HTS data validation, we identified two potential SL gene pairs, including the CD82 (essential gene)–KRAS (mutant gene) pair and CD82–NRAS pair in the DLD-1 colon cancer cell line (Spearman’s correlation p-values = 0.004786 and 0.00249, respectively). Based on further annotations by PubChem, we observed that digitonin targeted the complex comprising CD82, especially in KRAS-mutated HCT116 cancer cells. Moreover, we experimentally demonstrated that CD82 exhibited selective vulnerability in KRAS-mutant colorectal cancer. We used literature mining and HTS data to identify candidates for SL targets for RAS-mutant colon cancer." @default.
• W4296564689 created "2022-09-21" @default.
• W4296564689 creator A5044343503 @default.
• W4296564689 creator A5053912961 @default.
• W4296564689 creator A5062802526 @default.
• W4296564689 creator A5075660053 @default.
• W4296564689 date "2022-01-01" @default.
• W4296564689 modified "2023-10-14" @default.
• W4296564689 title "Literature-based translation from synthetic lethality screening into therapeutics targets: CD82 is a novel target for KRAS mutation in colon cancer" @default.
• W4296564689 cites W1523356059 @default.
• W4296564689 cites W1810524655 @default.
• W4296564689 cites W1895317372 @default.
• W4296564689 cites W1965624042 @default.
• W4296564689 cites W1989006164 @default.
• W4296564689 cites W2001673920 @default.
• W4296564689 cites W2005712021 @default.
• W4296564689 cites W2009931781 @default.
• W4296564689 cites W2021830424 @default.
• W4296564689 cites W2043398720 @default.
• W4296564689 cites W2045953361 @default.
• W4296564689 cites W2060572354 @default.
• W4296564689 cites W2096560421 @default.
• W4296564689 cites W2118151336 @default.
• W4296564689 cites W2123879591 @default.
• W4296564689 cites W2132215082 @default.
• W4296564689 cites W2133102806 @default.
• W4296564689 cites W2149843002 @default.
• W4296564689 cites W2163906048 @default.
• W4296564689 cites W2171972386 @default.
• W4296564689 cites W2209936495 @default.
• W4296564689 cites W2229453122 @default.
• W4296564689 cites W2275768000 @default.
• W4296564689 cites W2279299471 @default.
• W4296564689 cites W2344432445 @default.
• W4296564689 cites W2405904872 @default.
• W4296564689 cites W2618439945 @default.
• W4296564689 cites W2741508285 @default.
• W4296564689 cites W2766798501 @default.
• W4296564689 cites W2883529879 @default.
• W4296564689 cites W2905437169 @default.
• W4296564689 cites W2958222816 @default.
• W4296564689 cites W3005521521 @default.
• W4296564689 cites W3012379248 @default.
• W4296564689 cites W3087229737 @default.
• W4296564689 cites W3113262803 @default.
• W4296564689 cites W3172081492 @default.
• W4296564689 cites W4200222683 @default.
• W4296564689 cites W4291398362 @default.
• W4296564689 cites W2103737370 @default.
• W4296564689 doi "https://doi.org/10.1016/j.csbj.2022.09.025" @default.
• W4296564689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36212540" @default.
• W4296564689 hasPublicationYear "2022" @default.
• W4296564689 type Work @default.
• W4296564689 citedByCount "0" @default.
• W4296564689 crossrefType "journal-article" @default.
• W4296564689 hasAuthorship W4296564689A5044343503 @default.
• W4296564689 hasAuthorship W4296564689A5053912961 @default.
• W4296564689 hasAuthorship W4296564689A5062802526 @default.
• W4296564689 hasAuthorship W4296564689A5075660053 @default.
• W4296564689 hasBestOaLocation W42965646891 @default.
• W4296564689 hasConcept C104317684 @default.
• W4296564689 hasConcept C1167327 @default.
• W4296564689 hasConcept C121608353 @default.
• W4296564689 hasConcept C143065580 @default.
• W4296564689 hasConcept C21790070 @default.
• W4296564689 hasConcept C2778502085 @default.
• W4296564689 hasConcept C2781187634 @default.
• W4296564689 hasConcept C501734568 @default.
• W4296564689 hasConcept C502942594 @default.
• W4296564689 hasConcept C526805850 @default.
• W4296564689 hasConcept C54355233 @default.
• W4296564689 hasConcept C70721500 @default.
• W4296564689 hasConcept C86803240 @default.
• W4296564689 hasConceptScore W4296564689C104317684 @default.
• W4296564689 hasConceptScore W4296564689C1167327 @default.
• W4296564689 hasConceptScore W4296564689C121608353 @default.
• W4296564689 hasConceptScore W4296564689C143065580 @default.
• W4296564689 hasConceptScore W4296564689C21790070 @default.
• W4296564689 hasConceptScore W4296564689C2778502085 @default.
• W4296564689 hasConceptScore W4296564689C2781187634 @default.
• W4296564689 hasConceptScore W4296564689C501734568 @default.
• W4296564689 hasConceptScore W4296564689C502942594 @default.
• W4296564689 hasConceptScore W4296564689C526805850 @default.
• W4296564689 hasConceptScore W4296564689C54355233 @default.
• W4296564689 hasConceptScore W4296564689C70721500 @default.
• W4296564689 hasConceptScore W4296564689C86803240 @default.
• W4296564689 hasFunder F4320310848 @default.
• W4296564689 hasFunder F4320322795 @default.
• W4296564689 hasFunder F4320322933 @default.
• W4296564689 hasLocation W42965646891 @default.
• W4296564689 hasLocation W42965646892 @default.
• W4296564689 hasLocation W42965646893 @default.
• W4296564689 hasLocation W42965646894 @default.
• W4296564689 hasOpenAccess W4296564689 @default.
• W4296564689 hasPrimaryLocation W42965646891 @default.
• W4296564689 hasRelatedWork W2035394593 @default.
• W4296564689 hasRelatedWork W2064446750 @default.
• W4296564689 hasRelatedWork W2159947623 @default.

• next