Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296573721> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4296573721 abstract "Estimates of the fraction of nucleotide substitutions driven by positive selection vary widely across different species. Accounting for different estimates of positive selection has been difficult, in part because selection on polymorphism within a species is known to obscure a signal of positive selection between species. While methods have been developed to control for the confounding effects of negative selection against deleterious polymorphism, the impact of balancing selection on estimates of positive selection has not been assessed. In Saccharomyces cerevisiae, there is no signal of positive selection within protein coding sequences as the ratio of nonsynonymous to synonymous polymorphism is higher than that of divergence. To investigate the impact of balancing selection on estimates of positive selection we examined five genes with high rates of nonsynonymous polymorphism in S. cerevisiae relative to divergence from S. paradoxus. One of the genes, a high affinity zinc transporter ZRT1, shows an elevated rate of synonymous polymorphism indicative of balancing selection. The high rate of synonymous polymorphism coincides with nonsynonymous divergence between three haplotype groups, which we find to be functionally indistinguishable. We conclude that balancing selection is not likely to be a common cause of genes harboring a large excess of nonsynonymous polymorphism in yeast." @default.
- W4296573721 created "2022-09-21" @default.
- W4296573721 creator A5008350026 @default.
- W4296573721 creator A5077367340 @default.
- W4296573721 date "2012-12-01" @default.
- W4296573721 modified "2023-09-29" @default.
- W4296573721 title "ZRT1 harbors an excess of nonsynonymous polymorphism and shows evidence of balancing selection in Saccharomyces cerevisiae" @default.
- W4296573721 doi "https://doi.org/10.48550/arxiv.1212.0119" @default.
- W4296573721 hasPublicationYear "2012" @default.
- W4296573721 type Work @default.
- W4296573721 citedByCount "0" @default.
- W4296573721 crossrefType "posted-content" @default.
- W4296573721 hasAuthorship W4296573721A5008350026 @default.
- W4296573721 hasAuthorship W4296573721A5077367340 @default.
- W4296573721 hasBestOaLocation W42965737211 @default.
- W4296573721 hasConcept C104317684 @default.
- W4296573721 hasConcept C137848329 @default.
- W4296573721 hasConcept C138025448 @default.
- W4296573721 hasConcept C141231307 @default.
- W4296573721 hasConcept C149904235 @default.
- W4296573721 hasConcept C154945302 @default.
- W4296573721 hasConcept C41008148 @default.
- W4296573721 hasConcept C54355233 @default.
- W4296573721 hasConcept C68873052 @default.
- W4296573721 hasConcept C7386963 @default.
- W4296573721 hasConcept C78458016 @default.
- W4296573721 hasConcept C81917197 @default.
- W4296573721 hasConcept C86803240 @default.
- W4296573721 hasConcept C87253356 @default.
- W4296573721 hasConceptScore W4296573721C104317684 @default.
- W4296573721 hasConceptScore W4296573721C137848329 @default.
- W4296573721 hasConceptScore W4296573721C138025448 @default.
- W4296573721 hasConceptScore W4296573721C141231307 @default.
- W4296573721 hasConceptScore W4296573721C149904235 @default.
- W4296573721 hasConceptScore W4296573721C154945302 @default.
- W4296573721 hasConceptScore W4296573721C41008148 @default.
- W4296573721 hasConceptScore W4296573721C54355233 @default.
- W4296573721 hasConceptScore W4296573721C68873052 @default.
- W4296573721 hasConceptScore W4296573721C7386963 @default.
- W4296573721 hasConceptScore W4296573721C78458016 @default.
- W4296573721 hasConceptScore W4296573721C81917197 @default.
- W4296573721 hasConceptScore W4296573721C86803240 @default.
- W4296573721 hasConceptScore W4296573721C87253356 @default.
- W4296573721 hasLocation W42965737211 @default.
- W4296573721 hasLocation W42965737212 @default.
- W4296573721 hasLocation W42965737213 @default.
- W4296573721 hasOpenAccess W4296573721 @default.
- W4296573721 hasPrimaryLocation W42965737211 @default.
- W4296573721 hasRelatedWork W1940662708 @default.
- W4296573721 hasRelatedWork W1973812096 @default.
- W4296573721 hasRelatedWork W2029056863 @default.
- W4296573721 hasRelatedWork W2029510750 @default.
- W4296573721 hasRelatedWork W2035020365 @default.
- W4296573721 hasRelatedWork W2039199423 @default.
- W4296573721 hasRelatedWork W2057071452 @default.
- W4296573721 hasRelatedWork W2106275073 @default.
- W4296573721 hasRelatedWork W2126740061 @default.
- W4296573721 hasRelatedWork W3100536529 @default.
- W4296573721 isParatext "false" @default.
- W4296573721 isRetracted "false" @default.
- W4296573721 workType "article" @default.