Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296588461> ?p ?o ?g. }
- W4296588461 abstract "SUMMARY Within the chromatin, distal elements interact with promoters to regulate specific transcriptional programs. Histone acetylation, interfering with the net charges of the nucleosomes, is a key player in this regulation. Here, we report that the onco-protein SET is a critical determinant for the levels of histone acetylation within enhancers. We disclose that conditions in which SET is accumulated, including the severe Schinzel-Giedion Syndrome (SGS), are characterized by a failure in the usage of the distal regulatory regions typically employed during fate commitment. This is accompanied by the usage of alternative enhancers leading to a massive rewiring of the distal control of the gene transcription. This represents a (mal)adaptive mechanism that, on one side, allows to achieve a certain degree of differentiation, while on the other affects the fine and corrected maturation of the cells. Thus, we propose the differential in cis -regulation as a contributing factor to the pathological basis of the SET-related disorders in humans, including SGS, neurodevelopmental disorders, myeloproliferative diseases, and cancer." @default.
- W4296588461 created "2022-09-22" @default.
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- W4296588461 date "2022-09-13" @default.
- W4296588461 modified "2023-09-26" @default.
- W4296588461 title "Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition" @default.
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