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- W4296604505 abstract "Cisplatin is cancer chemotherapeutic agent that used in treatment of many types of solid cancers. However, cisplatin administration showed adverse effects including multi-organs toxicity including nephrotoxicity. Garlic is an anti-carcinogenic, antioxidant, anti-diabetic, Reno protective, anti-atherosclerotic, antibacterial, antifungal, and antihypertensive agent. Therefore, present study was conducted to investigate preventive effect of garlic powder on Cisplatin induced nephrotoxicity in male Wister rats. Twenty-one male Wister rats were assigned into three groups namely, C (as control negative group), CP (control positive) received two i.p injection of cisplatin at dose of 8 mg/kg and G-CP received two i.p injection of cisplatin at dose of 8 mg/kg and fed with 10% garlic powder diet. Serum samples were collected and kidney function parameters including creatinine, urea and uric acid levels were measured using colorimetric kits for these parameters. creatinine results showed a significant increasing in CP group rats compared with G-CP group. Urea results showed a significant increasing in CP group rats compared with G-CP group. Also, uric acid results showed a significant increasing in CP group rats compared with G-CP group. In conclusion, rats that fed with 10% garlic powder diet reduced nephrotoxicity that induced by Cisplatin." @default.
- W4296604505 created "2022-09-23" @default.
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- W4296604505 date "2022-08-12" @default.
- W4296604505 modified "2023-09-30" @default.
- W4296604505 title "Preventive effects of garlic powder on cisplatin-induced nephrotoxicity in male wister rats" @default.
- W4296604505 doi "https://doi.org/10.53730/ijhs.v6ns5.10845" @default.
- W4296604505 hasPublicationYear "2022" @default.
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