Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296618087> ?p ?o ?g. }
- W4296618087 abstract "Immune checkpoint blockade (ICB) therapy is a promising treatment for hepatocellular carcinoma (HCC). However, it is limited by low response rates. Tumour-infiltrating immune cells (TIICs), specifically CD8+ T cells, in the tumour microenvironment (TME) are related to tumour immune responses and are potential predictors for immunotherapeutic and survival outcomes. Therefore, we established a new CD8+ T cell-related genes prognostic index (CD8T-RGPI) for evaluating immune responses and prognostic outcomes for HCC. Using the TCGA databases, we evaluated the RNA-seq data of CD8+ T cell-related genes with gene co-expression network. Then, the CD8T-RGPI model was built by combining univariate Cox regression and the least absolute shrinkage and selection operator (LASSO) Cox regression analyses. The nomogram exhibited a good prediction ability for HCC patients' prognosis in either TCGA or ICGC databases. The CD8T-RGPI was elevated in patients with high T, M and TNM stages. Functional enrichment analyses revealed that in CD8T-RGPI high-risk group, tumour-related and immunosuppressive pathways, such as focal adhesion, aerobic glycolysis, HIF1 transcription factor pathway, IL-4 and IL-13 signalling were significantly enriched. Moreover, for CD8T-RGPI high-risk HCC patients, immune tolerance and immunosurveillance escape was associated with poor therapeutic outcomes for ICB therapy. The CD8T-RGPI low-risk HCC patients with elevated immune infiltration levels were associated with good immunotherapeutic responses to ICB. Our findings provide prospective prognostic biomarkers and elucidate on HCC immunotherapy." @default.
- W4296618087 created "2022-09-23" @default.
- W4296618087 creator A5011678003 @default.
- W4296618087 creator A5014350602 @default.
- W4296618087 creator A5022906854 @default.
- W4296618087 creator A5046292279 @default.
- W4296618087 creator A5053507328 @default.
- W4296618087 creator A5058060903 @default.
- W4296618087 creator A5058610085 @default.
- W4296618087 creator A5085252833 @default.
- W4296618087 creator A5090256491 @default.
- W4296618087 date "2022-09-29" @default.
- W4296618087 modified "2023-09-28" @default.
- W4296618087 title "A <scp>CD8</scp> <sup>+</sup> T cell‐related genes prognostic model for hepatocellular carcinoma patients" @default.
- W4296618087 cites W1966327575 @default.
- W4296618087 cites W2130430382 @default.
- W4296618087 cites W2214074259 @default.
- W4296618087 cites W2606367731 @default.
- W4296618087 cites W2755693293 @default.
- W4296618087 cites W2782930756 @default.
- W4296618087 cites W2893897533 @default.
- W4296618087 cites W2949586081 @default.
- W4296618087 cites W2957823147 @default.
- W4296618087 cites W2980387286 @default.
- W4296618087 cites W2981545603 @default.
- W4296618087 cites W3011803995 @default.
- W4296618087 cites W3011996328 @default.
- W4296618087 cites W3012610662 @default.
- W4296618087 cites W3012668557 @default.
- W4296618087 cites W3036499366 @default.
- W4296618087 cites W3038789517 @default.
- W4296618087 cites W3048777112 @default.
- W4296618087 cites W3093866409 @default.
- W4296618087 cites W3115178885 @default.
- W4296618087 cites W3121605775 @default.
- W4296618087 cites W3122332312 @default.
- W4296618087 cites W3122962572 @default.
- W4296618087 cites W3125168395 @default.
- W4296618087 cites W3128646645 @default.
- W4296618087 cites W3137024013 @default.
- W4296618087 cites W3150549785 @default.
- W4296618087 cites W3155790329 @default.
- W4296618087 cites W3162215872 @default.
- W4296618087 cites W3168371564 @default.
- W4296618087 cites W3171846186 @default.
- W4296618087 cites W3175752499 @default.
- W4296618087 cites W3197277611 @default.
- W4296618087 cites W3198005493 @default.
- W4296618087 cites W3199786216 @default.
- W4296618087 cites W3203252568 @default.
- W4296618087 cites W3211957571 @default.
- W4296618087 cites W3212903603 @default.
- W4296618087 cites W3215943325 @default.
- W4296618087 cites W3216333159 @default.
- W4296618087 cites W4200198881 @default.
- W4296618087 cites W4200503699 @default.
- W4296618087 cites W4206940321 @default.
- W4296618087 cites W4210774372 @default.
- W4296618087 cites W4220671035 @default.
- W4296618087 cites W4226468852 @default.
- W4296618087 cites W4280503962 @default.
- W4296618087 doi "https://doi.org/10.1111/sji.13216" @default.
- W4296618087 hasPublicationYear "2022" @default.
- W4296618087 type Work @default.
- W4296618087 citedByCount "1" @default.
- W4296618087 countsByYear W42966180872023 @default.
- W4296618087 crossrefType "journal-article" @default.
- W4296618087 hasAuthorship W4296618087A5011678003 @default.
- W4296618087 hasAuthorship W4296618087A5014350602 @default.
- W4296618087 hasAuthorship W4296618087A5022906854 @default.
- W4296618087 hasAuthorship W4296618087A5046292279 @default.
- W4296618087 hasAuthorship W4296618087A5053507328 @default.
- W4296618087 hasAuthorship W4296618087A5058060903 @default.
- W4296618087 hasAuthorship W4296618087A5058610085 @default.
- W4296618087 hasAuthorship W4296618087A5085252833 @default.
- W4296618087 hasAuthorship W4296618087A5090256491 @default.
- W4296618087 hasConcept C104317684 @default.
- W4296618087 hasConcept C126322002 @default.
- W4296618087 hasConcept C143998085 @default.
- W4296618087 hasConcept C147483822 @default.
- W4296618087 hasConcept C167672396 @default.
- W4296618087 hasConcept C203014093 @default.
- W4296618087 hasConcept C2777546739 @default.
- W4296618087 hasConcept C2778019345 @default.
- W4296618087 hasConcept C3017392945 @default.
- W4296618087 hasConcept C502942594 @default.
- W4296618087 hasConcept C54355233 @default.
- W4296618087 hasConcept C71924100 @default.
- W4296618087 hasConcept C86803240 @default.
- W4296618087 hasConceptScore W4296618087C104317684 @default.
- W4296618087 hasConceptScore W4296618087C126322002 @default.
- W4296618087 hasConceptScore W4296618087C143998085 @default.
- W4296618087 hasConceptScore W4296618087C147483822 @default.
- W4296618087 hasConceptScore W4296618087C167672396 @default.
- W4296618087 hasConceptScore W4296618087C203014093 @default.
- W4296618087 hasConceptScore W4296618087C2777546739 @default.
- W4296618087 hasConceptScore W4296618087C2778019345 @default.
- W4296618087 hasConceptScore W4296618087C3017392945 @default.
- W4296618087 hasConceptScore W4296618087C502942594 @default.
- W4296618087 hasConceptScore W4296618087C54355233 @default.