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- W4296628513 endingPage "100640" @default.
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- W4296628513 abstract "Dedifferentiation in renal cell carcinoma (RCC), either sarcomatoid or rhabdoid, is an infrequent event that may occur heterogeneously in the setting of any RCC histology and is associated with poor outcomes. Sarcomatoid dedifferentiation is associated with inferior survival with angiogenesis targeted therapy and infrequent responses to cytotoxic chemotherapy. However, immune checkpoint therapy has significantly improved outcomes for patients with sarcomatoid dedifferentiation. Biologically, sarcomatoid dedifferentiation has increased programmed death-ligand 1 (PD-L1) expression and an inflamed tumor microenvironment, in addition to other distinct molecular alterations. Less is known about rhabdoid dedifferentiation from either a clinical, biological, or therapeutic perspective. In this focused review, we will discuss the prognostic implications, outcomes with systemic therapy, and underlying biology in RCC with either sarcomatoid or rhabdoid dedifferentiation present." @default.
- W4296628513 created "2022-09-23" @default.
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- W4296628513 date "2022-01-01" @default.
- W4296628513 modified "2023-10-14" @default.
- W4296628513 title "The significance of sarcomatoid and rhabdoid dedifferentiation in renal cell carcinoma" @default.
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- W4296628513 doi "https://doi.org/10.1016/j.ctarc.2022.100640" @default.
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