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• W4296633645 abstract "Chronic exposure to stressful experiences impairs synaptic plasticity. Previous studies have shown that the spine densities of pyramidal neurons, the turnover of mushroom-type spines, and the excitatory–inhibitory balance in the primary somatosensory cortex (S1) are modulated by stress. Trans-synaptic cell adhesion molecules (CAMs) are implicated in stress-induced synaptic deficits. However, it remains unknown whether stress dysregulates CAMs in S1 and thereby impairs synaptic plasticity. In this study, we applied the early-life stress (ELS), chronic social defeat stress (CSDS), and chronic restraint stress paradigms and measured the mRNA levels of <i>nectin1</i> in S1 of wild-type and conditional forebrain corticotropin-releasing hormone receptor 1 type (CRHR1) conditional knockout mice. We found that ELS increased <i>nectin1</i> mRNA levels in S1 in adult but not adolescent mice. Moreover, CSDS increased the <i>nectin1</i> mRNA levels in S1 in adult mice via the CRH-CRHR1 system. Our findings suggest that S1 is vulnerable to repeated stress exposures at some life stages, and dysregulated <i>nectin1</i> expression may underlie stress-induced structural and functional abnormalities in S1." @default.
• W4296633645 created "2022-09-23" @default.
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• W4296633645 date "2022-09-01" @default.
• W4296633645 modified "2023-09-26" @default.
• W4296633645 title "Effects of chronic stress on <i>nectin1</i> levels in the mouse primary somatosensory cortex" @default.
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• W4296633645 doi "https://doi.org/10.26599/sab.2022.9060013" @default.
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