FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296642782> ?p ?o ?g. }

• W4296642782 abstract "Abstract Introduction Coronavirus disease 2019 (COVID‐19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID‐19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID‐19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID‐19 to neurologic illness, both short and long term. Methods This article describes what is known so far in terms of links among COVID‐19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS‐CoV‐2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions. Results Successful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe. Discussion The Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long‐term neurocognitive sequelae of SARS‐CoV‐2 infection. Key Points The following review describes what is known so far in terms of molecular and epidemiological links among COVID‐19, the brain, neurological symptoms, and AD and related dementias (ADRD) The primary objective of this large‐scale collaboration is to clarify the pathogenesis of ADRD and to advance our understanding of the impact of a neurotropic virus on the long‐term risk of cognitive decline and other CNS sequelae. No available evidence supports the notion that cognitive impairment after SARS‐CoV‐2 infection is a form of dementia (ADRD or otherwise). The longitudinal methodologies espoused by the consortium are intended to provide data to answer this question as clearly as possible controlling for possible confounders. Our specific hypothesis is that SARS‐CoV‐2 triggers ADRD‐like pathology following the extended olfactory cortical network (EOCN) in older individuals with specific genetic susceptibility. The proposed harmonization strategies and flexible study designs offer the possibility to include large samples of under‐represented racial and ethnic groups, creating a rich set of harmonized cohorts for future studies of the pathophysiology, determinants, long‐term consequences, and trends in cognitive aging, ADRD, and vascular disease. We provide a framework for current and future studies to be carried out within the Consortium. and offers a “green paper” to the research community with a very broad, global base of support, on tools suitable for low‐ and middle‐income countries aimed to compare and combine future longitudinal data on the topic. The Consortium proposes a combination of design and statistical methods as a means of approaching causal inference of the COVID‐19 neuropsychiatric sequelae. We expect that deep phenotyping of neuropsychiatric sequelae may provide a series of candidate syndromes with phenomenological and biological characterization that can be further explored. By generating high‐quality harmonized data across sites we aim to capture both descriptive and, where possible, causal associations." @default.
• W4296642782 created "2022-09-23" @default.
• W4296642782 creator A5000005400 @default.
• W4296642782 creator A5000178337 @default.
• W4296642782 creator A5001912833 @default.
• W4296642782 creator A5002040910 @default.
• W4296642782 creator A5004434116 @default.
• W4296642782 creator A5004538115 @default.
• W4296642782 creator A5004775175 @default.
• W4296642782 creator A5004897106 @default.
• W4296642782 creator A5006702259 @default.
• W4296642782 creator A5007970435 @default.
• W4296642782 creator A5008023001 @default.
• W4296642782 creator A5009082904 @default.
• W4296642782 creator A5009282322 @default.
• W4296642782 creator A5011109380 @default.
• W4296642782 creator A5011863508 @default.
• W4296642782 creator A5011921328 @default.
• W4296642782 creator A5014310950 @default.
• W4296642782 creator A5014631279 @default.
• W4296642782 creator A5016688715 @default.
• W4296642782 creator A5018009645 @default.
• W4296642782 creator A5018529520 @default.
• W4296642782 creator A5020717640 @default.
• W4296642782 creator A5022954543 @default.
• W4296642782 creator A5023556217 @default.
• W4296642782 creator A5024283258 @default.
• W4296642782 creator A5024302085 @default.
• W4296642782 creator A5025094088 @default.
• W4296642782 creator A5025313057 @default.
• W4296642782 creator A5026336275 @default.
• W4296642782 creator A5026553770 @default.
• W4296642782 creator A5027031712 @default.
• W4296642782 creator A5028361013 @default.
• W4296642782 creator A5028606685 @default.
• W4296642782 creator A5032171459 @default.
• W4296642782 creator A5032352602 @default.
• W4296642782 creator A5032816047 @default.
• W4296642782 creator A5033402450 @default.
• W4296642782 creator A5033620415 @default.
• W4296642782 creator A5033666975 @default.
• W4296642782 creator A5033987941 @default.
• W4296642782 creator A5034541609 @default.
• W4296642782 creator A5035118255 @default.
• W4296642782 creator A5036174826 @default.
• W4296642782 creator A5036518738 @default.
• W4296642782 creator A5037517992 @default.
• W4296642782 creator A5038211294 @default.
• W4296642782 creator A5038780154 @default.
• W4296642782 creator A5039041555 @default.
• W4296642782 creator A5040490170 @default.
• W4296642782 creator A5041013576 @default.
• W4296642782 creator A5044769698 @default.
• W4296642782 creator A5045026086 @default.
• W4296642782 creator A5045350239 @default.
• W4296642782 creator A5047390943 @default.
• W4296642782 creator A5049363606 @default.
• W4296642782 creator A5049578735 @default.
• W4296642782 creator A5051635255 @default.
• W4296642782 creator A5052092163 @default.
• W4296642782 creator A5053331010 @default.
• W4296642782 creator A5057278613 @default.
• W4296642782 creator A5057733690 @default.
• W4296642782 creator A5058286274 @default.
• W4296642782 creator A5060100183 @default.
• W4296642782 creator A5062838095 @default.
• W4296642782 creator A5064540155 @default.
• W4296642782 creator A5066465398 @default.
• W4296642782 creator A5067829885 @default.
• W4296642782 creator A5068915202 @default.
• W4296642782 creator A5069166766 @default.
• W4296642782 creator A5071093110 @default.
• W4296642782 creator A5071934380 @default.
• W4296642782 creator A5072218458 @default.
• W4296642782 creator A5072287419 @default.
• W4296642782 creator A5072836874 @default.
• W4296642782 creator A5073964885 @default.
• W4296642782 creator A5074157161 @default.
• W4296642782 creator A5074331541 @default.
• W4296642782 creator A5075394738 @default.
• W4296642782 creator A5075741409 @default.
• W4296642782 creator A5076061467 @default.
• W4296642782 creator A5077411586 @default.
• W4296642782 creator A5078771331 @default.
• W4296642782 creator A5081833036 @default.
• W4296642782 creator A5083114280 @default.
• W4296642782 creator A5083115114 @default.
• W4296642782 creator A5085124093 @default.
• W4296642782 creator A5085153423 @default.
• W4296642782 creator A5085160808 @default.
• W4296642782 creator A5085328315 @default.
• W4296642782 creator A5085401513 @default.
• W4296642782 creator A5085651175 @default.
• W4296642782 creator A5086224910 @default.
• W4296642782 creator A5086898186 @default.
• W4296642782 creator A5087114901 @default.
• W4296642782 creator A5087762288 @default.
• W4296642782 creator A5089813112 @default.
• W4296642782 date "2022-01-01" @default.
• W4296642782 modified "2023-10-14" @default.

• next