Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296688996> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4296688996 endingPage "428" @default.
- W4296688996 startingPage "423" @default.
- W4296688996 abstract "This research work aimed to develop and evaluate the microsponge formulations for Sulindac sodium. Sulindac sodium a poorly water-soluble drug with high first-pass metabolism is available only as conventional tablets. Thus, an attempt was made to formulate a drug-loaded microsponge to eliminate the first-pass metabolism and also improve the bio-availability of the drug. This work aimed to prepare a stable microsponge formulation of sulindac sodium for the enhancement of bioavailability and reducing the dose frequency. The quasi emulsion solvent diffusion approach was used to create the microsponges. The percentage yield, drug load efficiency, morphological analysis, in vitro drug release and stability studies were evaluated. Based on the result selected for the optimized formulation SM5, the morphology of the optimized formulation was by scanned electron microscopy which was found to be uniform and containing pores without any crystals. The formulation SM5 was found to be in an optimized formulation which shows 92.05% release at 12 hr. Stability studies showed that indicated negligible levels of changes were observed in load efficiency, morphological analysis and in vitro release, indicating the susceptibility to stability problems during storage at room temperature and 40°C/75%RH was observed after 3 months. On the basis of the findings, drug-loaded microsponges show improvised release behaviour and provide an effective modified route of administration" @default.
- W4296688996 created "2022-09-23" @default.
- W4296688996 creator A5058055121 @default.
- W4296688996 creator A5069778475 @default.
- W4296688996 creator A5070662005 @default.
- W4296688996 creator A5071152113 @default.
- W4296688996 date "2022-09-20" @default.
- W4296688996 modified "2023-09-26" @default.
- W4296688996 title "Formulation Development and Evaluation of Drug Loaded Microsponges of Sulindac Sodium" @default.
- W4296688996 doi "https://doi.org/10.5530/ajbls.2022.11.57" @default.
- W4296688996 hasPublicationYear "2022" @default.
- W4296688996 type Work @default.
- W4296688996 citedByCount "0" @default.
- W4296688996 crossrefType "journal-article" @default.
- W4296688996 hasAuthorship W4296688996A5058055121 @default.
- W4296688996 hasAuthorship W4296688996A5069778475 @default.
- W4296688996 hasAuthorship W4296688996A5070662005 @default.
- W4296688996 hasAuthorship W4296688996A5071152113 @default.
- W4296688996 hasBestOaLocation W42966889961 @default.
- W4296688996 hasConcept C105795698 @default.
- W4296688996 hasConcept C169222746 @default.
- W4296688996 hasConcept C178790620 @default.
- W4296688996 hasConcept C181389837 @default.
- W4296688996 hasConcept C185592680 @default.
- W4296688996 hasConcept C192562407 @default.
- W4296688996 hasConcept C2776241388 @default.
- W4296688996 hasConcept C2778484676 @default.
- W4296688996 hasConcept C2780035454 @default.
- W4296688996 hasConcept C2780471494 @default.
- W4296688996 hasConcept C33923547 @default.
- W4296688996 hasConcept C43617362 @default.
- W4296688996 hasConcept C71924100 @default.
- W4296688996 hasConcept C98274493 @default.
- W4296688996 hasConceptScore W4296688996C105795698 @default.
- W4296688996 hasConceptScore W4296688996C169222746 @default.
- W4296688996 hasConceptScore W4296688996C178790620 @default.
- W4296688996 hasConceptScore W4296688996C181389837 @default.
- W4296688996 hasConceptScore W4296688996C185592680 @default.
- W4296688996 hasConceptScore W4296688996C192562407 @default.
- W4296688996 hasConceptScore W4296688996C2776241388 @default.
- W4296688996 hasConceptScore W4296688996C2778484676 @default.
- W4296688996 hasConceptScore W4296688996C2780035454 @default.
- W4296688996 hasConceptScore W4296688996C2780471494 @default.
- W4296688996 hasConceptScore W4296688996C33923547 @default.
- W4296688996 hasConceptScore W4296688996C43617362 @default.
- W4296688996 hasConceptScore W4296688996C71924100 @default.
- W4296688996 hasConceptScore W4296688996C98274493 @default.
- W4296688996 hasIssue "2" @default.
- W4296688996 hasLocation W42966889961 @default.
- W4296688996 hasOpenAccess W4296688996 @default.
- W4296688996 hasPrimaryLocation W42966889961 @default.
- W4296688996 hasRelatedWork W118449968 @default.
- W4296688996 hasRelatedWork W1508531867 @default.
- W4296688996 hasRelatedWork W2030193124 @default.
- W4296688996 hasRelatedWork W2096173832 @default.
- W4296688996 hasRelatedWork W2616206605 @default.
- W4296688996 hasRelatedWork W2744667494 @default.
- W4296688996 hasRelatedWork W3024440267 @default.
- W4296688996 hasRelatedWork W4307128310 @default.
- W4296688996 hasRelatedWork W2181418653 @default.
- W4296688996 hasRelatedWork W2184264123 @default.
- W4296688996 hasVolume "11" @default.
- W4296688996 isParatext "false" @default.
- W4296688996 isRetracted "false" @default.
- W4296688996 workType "article" @default.