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- W4296693399 abstract "N-Acylsulfonamides possess an additional carbonyl function compared to their sulfonamide analogues. Due to their unique physico-chemical properties, interest in molecules containing the N-acylsulfonamide moiety and especially nucleoside derivatives is growing in the field of medicinal chemistry. The recent renewal of interest in antiviral drugs derived from nucleosides containing a sulfonamide function has led us to evaluate the therapeutic potential of N-acylsulfonamide analogues. While these compounds are usually obtained by a difficult acylation of sulfonamides, we report here the easy and efficient synthesis of 20 4'-(N-acylsulfonamide) adenosine derivatives via the sulfo-click reaction. The target compounds were obtained from thioacid and sulfonyl azide synthons in excellent yields and were evaluated as potential inhibitors of the SARS-CoV-2 RNA cap N7-guanine-methyltransferase nsp14." @default.
- W4296693399 created "2022-09-23" @default.
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- W4296693399 date "2022-01-01" @default.
- W4296693399 modified "2023-10-12" @default.
- W4296693399 title "Facile access to 4′-(<i>N</i>-acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap <i>N</i>7-guanine-methyltransferase nsp14" @default.
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- W4296693399 doi "https://doi.org/10.1039/d2ob01569b" @default.
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