Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296700192> ?p ?o ?g. }
- W4296700192 abstract "MR1 is a highly conserved microbial immune-detection system in mammals. It captures vitamin B-related metabolite antigens from diverse microbes and presents them at the cell surface to stimulate MR1-restricted lymphocytes including mucosal-associated invariant T (MAIT) cells. MR1 presentation and MAIT cell recognition mediate homeostasis through host defense and tissue repair. The cellular mechanisms regulating MR1 cell surface expression are critical to its function and MAIT cell recognition, yet they are poorly defined. Here, we report that human MR1 is equipped with a tyrosine-based motif in its cytoplasmic domain that mediates low affinity binding with the endocytic adaptor protein 2 (AP2) complex. This interaction controls the kinetics of MR1 internalization from the cell surface and minimizes recycling. We propose MR1 uses AP2 endocytosis to define the duration of antigen presentation to MAIT cells and the detection of a microbial metabolic signature by the immune system." @default.
- W4296700192 created "2022-09-23" @default.
- W4296700192 creator A5002956492 @default.
- W4296700192 creator A5015434839 @default.
- W4296700192 creator A5017413531 @default.
- W4296700192 creator A5029683006 @default.
- W4296700192 creator A5029800824 @default.
- W4296700192 creator A5041502915 @default.
- W4296700192 creator A5041767515 @default.
- W4296700192 creator A5047260851 @default.
- W4296700192 creator A5053439487 @default.
- W4296700192 creator A5057759042 @default.
- W4296700192 creator A5062346523 @default.
- W4296700192 creator A5071809291 @default.
- W4296700192 creator A5072318020 @default.
- W4296700192 creator A5075184522 @default.
- W4296700192 creator A5081880237 @default.
- W4296700192 creator A5090563573 @default.
- W4296700192 creator A5091121859 @default.
- W4296700192 creator A5091815085 @default.
- W4296700192 date "2022-09-21" @default.
- W4296700192 modified "2023-10-09" @default.
- W4296700192 title "A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells" @default.
- W4296700192 cites W1520091697 @default.
- W4296700192 cites W1564678593 @default.
- W4296700192 cites W1977099733 @default.
- W4296700192 cites W1982688638 @default.
- W4296700192 cites W1984879151 @default.
- W4296700192 cites W1988573003 @default.
- W4296700192 cites W2004794077 @default.
- W4296700192 cites W2017127553 @default.
- W4296700192 cites W2019187704 @default.
- W4296700192 cites W2023132550 @default.
- W4296700192 cites W2032444338 @default.
- W4296700192 cites W2039189450 @default.
- W4296700192 cites W2040646246 @default.
- W4296700192 cites W2050169742 @default.
- W4296700192 cites W2061153820 @default.
- W4296700192 cites W2065252029 @default.
- W4296700192 cites W2066015352 @default.
- W4296700192 cites W2068487285 @default.
- W4296700192 cites W2073247934 @default.
- W4296700192 cites W2078890331 @default.
- W4296700192 cites W2080049667 @default.
- W4296700192 cites W2086341057 @default.
- W4296700192 cites W2104031571 @default.
- W4296700192 cites W2111436070 @default.
- W4296700192 cites W2114083522 @default.
- W4296700192 cites W2127749855 @default.
- W4296700192 cites W2128073840 @default.
- W4296700192 cites W2131134035 @default.
- W4296700192 cites W2136101171 @default.
- W4296700192 cites W2140772054 @default.
- W4296700192 cites W2145089843 @default.
- W4296700192 cites W2152770371 @default.
- W4296700192 cites W2156460811 @default.
- W4296700192 cites W2158266834 @default.
- W4296700192 cites W2159166889 @default.
- W4296700192 cites W2162709457 @default.
- W4296700192 cites W2201689894 @default.
- W4296700192 cites W2236872686 @default.
- W4296700192 cites W2288573834 @default.
- W4296700192 cites W2323955433 @default.
- W4296700192 cites W2327739049 @default.
- W4296700192 cites W2337233942 @default.
- W4296700192 cites W2436945295 @default.
- W4296700192 cites W2514929667 @default.
- W4296700192 cites W2520295551 @default.
- W4296700192 cites W2526887159 @default.
- W4296700192 cites W2545982909 @default.
- W4296700192 cites W2566797669 @default.
- W4296700192 cites W2568848023 @default.
- W4296700192 cites W2586227194 @default.
- W4296700192 cites W2592774439 @default.
- W4296700192 cites W2601885162 @default.
- W4296700192 cites W2614152856 @default.
- W4296700192 cites W2734258797 @default.
- W4296700192 cites W2793567263 @default.
- W4296700192 cites W2830758472 @default.
- W4296700192 cites W2883450285 @default.
- W4296700192 cites W2886403363 @default.
- W4296700192 cites W2921896742 @default.
- W4296700192 cites W2935110817 @default.
- W4296700192 cites W2969596680 @default.
- W4296700192 cites W2970705750 @default.
- W4296700192 cites W2981494076 @default.
- W4296700192 cites W2995506203 @default.
- W4296700192 cites W2996045117 @default.
- W4296700192 cites W2998801145 @default.
- W4296700192 cites W2999041150 @default.
- W4296700192 cites W3009934661 @default.
- W4296700192 cites W3010955735 @default.
- W4296700192 cites W3037239183 @default.
- W4296700192 cites W3043864335 @default.
- W4296700192 cites W3045318893 @default.
- W4296700192 cites W3082258098 @default.
- W4296700192 cites W3087215755 @default.
- W4296700192 cites W3177150916 @default.
- W4296700192 cites W3179327051 @default.
- W4296700192 cites W3183450452 @default.