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• W4296701253 abstract "T cells specific for SARS-CoV-2 are thought to protect against infection and development of COVID-19, but direct evidence for this is lacking. Here, we associated whole-blood-based measurement of SARS-CoV-2-specific interferon-γ-positive T cell responses with positive COVID-19 diagnostic (PCR and/or lateral flow) test results up to 6 months post-blood sampling. Amongst 148 participants donating venous blood samples, SARS-CoV-2-specific T cell response magnitude is significantly greater in those who remain protected versus those who become infected (P < 0.0001); relatively low magnitude T cell response results in a 43.2% risk of infection, whereas high magnitude reduces this risk to 5.4%. These findings are recapitulated in a further 299 participants testing a scalable capillary blood-based assay that could facilitate the acquisition of population-scale T cell immunity data (14.9% and 4.4%, respectively). Hence, measurement of SARS-CoV-2-specific T cells can prognosticate infection risk and should be assessed when monitoring individual and population immunity status." @default.
• W4296701253 created "2022-09-23" @default.
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• W4296701253 date "2022-09-21" @default.
• W4296701253 modified "2023-10-15" @default.
• W4296701253 title "Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity" @default.
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• W4296701253 doi "https://doi.org/10.1038/s41467-022-32985-8" @default.
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