FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296709650> ?p ?o ?g. }

• W4296709650 abstract "BACKGROUNDInsulin resistance of the brain can unfavorably affect long-term weight maintenance and body fat distribution. Little is known if and how brain insulin sensitivity can be restored in humans. We aimed to evaluate the effects of an exercise intervention on insulin sensitivity of the brain and how this relates to exercise-induced changes in whole-body metabolism and behavior.METHODSIn this clinical trial, sedentary participants who were overweight and obese underwent an 8-week supervised aerobic training intervention. Brain insulin sensitivity was assessed in 21 participants (14 women, 7 men; age range 21-59 years; BMI range 27.5-45.5 kg/m2) using functional MRI, combined with intranasal administration of insulin, before and after the intervention.RESULTSThe exercise program resulted in enhanced brain insulin action to the level of a person of healthy weight, demonstrated by increased insulin-induced striatal activity and strengthened hippocampal functional connectivity. Improved brain insulin action correlated with increased mitochondrial respiration in skeletal muscle, reductions in visceral fat and hunger, as well as improved cognition. Mediation analyses suggest that improved brain insulin responsiveness helps mediate the peripheral exercise effects leading to healthier body fat distribution and reduced perception of hunger.CONCLUSIONOur study demonstrates that an 8-week exercise intervention in sedentary individuals can restore insulin action in the brain. Hence, the ameliorating benefits of exercise toward brain insulin resistance may provide an objective therapeutic target in humans in the challenge to reduce diabetes risk factors.TRIAL REGISTRATIONClinicalTrials.gov (NCT03151590).FUNDINGBMBF/DZD 01GI0925." @default.
• W4296709650 created "2022-09-23" @default.
• W4296709650 creator A5008882033 @default.
• W4296709650 creator A5010961147 @default.
• W4296709650 creator A5011064224 @default.
• W4296709650 creator A5013839934 @default.
• W4296709650 creator A5014505944 @default.
• W4296709650 creator A5014697724 @default.
• W4296709650 creator A5015192785 @default.
• W4296709650 creator A5024563487 @default.
• W4296709650 creator A5033072669 @default.
• W4296709650 creator A5041134719 @default.
• W4296709650 creator A5043503435 @default.
• W4296709650 creator A5056393712 @default.
• W4296709650 creator A5060277438 @default.
• W4296709650 creator A5062462205 @default.
• W4296709650 creator A5066447951 @default.
• W4296709650 creator A5069483581 @default.
• W4296709650 creator A5083123944 @default.
• W4296709650 creator A5084404405 @default.
• W4296709650 date "2022-09-22" @default.
• W4296709650 modified "2023-10-10" @default.
• W4296709650 title "Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese" @default.
• W4296709650 cites W1847471344 @default.
• W4296709650 cites W1921700755 @default.
• W4296709650 cites W1964434833 @default.
• W4296709650 cites W1968074115 @default.
• W4296709650 cites W1970466182 @default.
• W4296709650 cites W1982060139 @default.
• W4296709650 cites W1983538154 @default.
• W4296709650 cites W2003413351 @default.
• W4296709650 cites W2014160361 @default.
• W4296709650 cites W2015620326 @default.
• W4296709650 cites W2021005943 @default.
• W4296709650 cites W2029616112 @default.
• W4296709650 cites W2030421672 @default.
• W4296709650 cites W2031650042 @default.
• W4296709650 cites W2037226098 @default.
• W4296709650 cites W2039771829 @default.
• W4296709650 cites W2040181124 @default.
• W4296709650 cites W2051221009 @default.
• W4296709650 cites W2053859901 @default.
• W4296709650 cites W2057550180 @default.
• W4296709650 cites W2060510350 @default.
• W4296709650 cites W2078940647 @default.
• W4296709650 cites W2086190854 @default.
• W4296709650 cites W2112024831 @default.
• W4296709650 cites W2117740211 @default.
• W4296709650 cites W2128507030 @default.
• W4296709650 cites W2133374742 @default.
• W4296709650 cites W2136915688 @default.
• W4296709650 cites W2148048066 @default.
• W4296709650 cites W2152774501 @default.
• W4296709650 cites W2155621221 @default.
• W4296709650 cites W2170596893 @default.
• W4296709650 cites W2199402593 @default.
• W4296709650 cites W2462157064 @default.
• W4296709650 cites W2497601590 @default.
• W4296709650 cites W2512005241 @default.
• W4296709650 cites W2555506632 @default.
• W4296709650 cites W2586809204 @default.
• W4296709650 cites W2611676290 @default.
• W4296709650 cites W2738415419 @default.
• W4296709650 cites W2766902973 @default.
• W4296709650 cites W2786962139 @default.
• W4296709650 cites W2918857132 @default.
• W4296709650 cites W2926816892 @default.
• W4296709650 cites W2937525912 @default.
• W4296709650 cites W2940449086 @default.
• W4296709650 cites W2951463049 @default.
• W4296709650 cites W2954040700 @default.
• W4296709650 cites W2957698310 @default.
• W4296709650 cites W2974411210 @default.
• W4296709650 cites W2983574747 @default.
• W4296709650 cites W3017215630 @default.
• W4296709650 cites W3027292275 @default.
• W4296709650 cites W3034731041 @default.
• W4296709650 cites W3045828365 @default.
• W4296709650 cites W3080553601 @default.
• W4296709650 cites W3087052420 @default.
• W4296709650 cites W3092482674 @default.
• W4296709650 cites W3128065054 @default.
• W4296709650 cites W3167467420 @default.
• W4296709650 cites W3170389531 @default.
• W4296709650 cites W3210195064 @default.
• W4296709650 cites W4200109598 @default.
• W4296709650 cites W4205857090 @default.
• W4296709650 cites W4206172179 @default.
• W4296709650 cites W4213149191 @default.
• W4296709650 cites W4223529453 @default.
• W4296709650 cites W4229845697 @default.
• W4296709650 cites W4280552691 @default.
• W4296709650 cites W4283068802 @default.
• W4296709650 cites W44929223 @default.
• W4296709650 doi "https://doi.org/10.1172/jci.insight.161498" @default.
• W4296709650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36134657" @default.
• W4296709650 hasPublicationYear "2022" @default.
• W4296709650 type Work @default.
• W4296709650 citedByCount "6" @default.
• W4296709650 countsByYear W42967096502022 @default.

• next