FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296770176> ?p ?o ?g. }

• W4296770176 endingPage "129" @default.
• W4296770176 startingPage "115" @default.
• W4296770176 abstract "The iron (Fe) metabolism plays important role in regulating systemic metabolism and obesity development. The Fe inside cells can form iron-sulfur (Fe-S) clusters, which are usually assembled into target proteins with the help of a conserved cluster assembly machinery. Family with sequence similarity 96A (FAM96A; also designated CIAO2A) is a cytosolic Fe-S assembly protein involved in the regulation of cellular Fe homeostasis. However, the biological function of FAM96A in vivo is still incompletely defined. Here, we tested the role of FAM96A in regulating organismal Fe metabolism, which is relevant to obesity and adipose tissue homeostasis. We found that in mice genetically lacking FAM96A globally, intracellular Fe homeostasis was interrupted in both white and brown adipocytes, but the systemic Fe level was normal. FAM96A deficiency led to adipocyte hypertrophy and organismal energy expenditure reduction even under nonobesogenic normal chow diet-fed conditions. Mechanistically, FAM96A deficiency promoted mechanistic target of rapamycin (mTOR) signaling in adipocytes, leading to an elevation of de novo lipogenesis and, therefore, fat mass accumulation. Furthermore, it also caused mitochondrial defects, including defects in mitochondrial number, ultrastructure, redox activity, and metabolic function in brown adipocytes, which are known to be critical for the control of energy balance. Moreover, adipocyte-selective FAM96A knockout partially phenocopied global FAM96A deficiency with adipocyte hypertrophy and organismal energy expenditure defects but the mice were resistant to high-fat diet-induced weight gain. Thus, FAM96A in adipocytes may autonomously act as a critical gatekeeper of organismal energy balance by coupling Fe metabolism to adipose tissue homeostasis." @default.
• W4296770176 created "2022-09-23" @default.
• W4296770176 creator A5006065770 @default.
• W4296770176 creator A5017052469 @default.
• W4296770176 creator A5017859483 @default.
• W4296770176 creator A5019005078 @default.
• W4296770176 creator A5029484872 @default.
• W4296770176 creator A5041838620 @default.
• W4296770176 creator A5042548151 @default.
• W4296770176 creator A5052468413 @default.
• W4296770176 creator A5060291926 @default.
• W4296770176 creator A5073124436 @default.
• W4296770176 creator A5087929637 @default.
• W4296770176 creator A5088887574 @default.
• W4296770176 date "2022-11-01" @default.
• W4296770176 modified "2023-10-13" @default.
• W4296770176 title "FAM96A is essential for maintaining organismal energy balance and adipose tissue homeostasis in mice" @default.
• W4296770176 cites W1631449371 @default.
• W4296770176 cites W1936929000 @default.
• W4296770176 cites W1964601437 @default.
• W4296770176 cites W1972766737 @default.
• W4296770176 cites W1976725682 @default.
• W4296770176 cites W1985806842 @default.
• W4296770176 cites W1986346641 @default.
• W4296770176 cites W1995039474 @default.
• W4296770176 cites W1996039273 @default.
• W4296770176 cites W1997684038 @default.
• W4296770176 cites W2013979638 @default.
• W4296770176 cites W2039181523 @default.
• W4296770176 cites W2042212143 @default.
• W4296770176 cites W2055026601 @default.
• W4296770176 cites W2065952016 @default.
• W4296770176 cites W2067997447 @default.
• W4296770176 cites W2081768689 @default.
• W4296770176 cites W2113576333 @default.
• W4296770176 cites W2114381345 @default.
• W4296770176 cites W2125689907 @default.
• W4296770176 cites W2147086995 @default.
• W4296770176 cites W2150680729 @default.
• W4296770176 cites W2155089111 @default.
• W4296770176 cites W2305670323 @default.
• W4296770176 cites W2593816418 @default.
• W4296770176 cites W2626486519 @default.
• W4296770176 cites W2793630235 @default.
• W4296770176 cites W2797532322 @default.
• W4296770176 cites W2885085538 @default.
• W4296770176 cites W2917520831 @default.
• W4296770176 cites W2972618106 @default.
• W4296770176 cites W2985271101 @default.
• W4296770176 cites W3009717183 @default.
• W4296770176 cites W3012064266 @default.
• W4296770176 cites W3015175137 @default.
• W4296770176 cites W3047361803 @default.
• W4296770176 cites W3113985128 @default.
• W4296770176 cites W3129451191 @default.
• W4296770176 cites W3157893392 @default.
• W4296770176 cites W3159800497 @default.
• W4296770176 cites W3175903324 @default.
• W4296770176 cites W4210852169 @default.
• W4296770176 cites W4223419774 @default.
• W4296770176 cites W4225288460 @default.
• W4296770176 cites W4283701282 @default.
• W4296770176 cites W67442820 @default.
• W4296770176 doi "https://doi.org/10.1016/j.freeradbiomed.2022.09.011" @default.
• W4296770176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36150559" @default.
• W4296770176 hasPublicationYear "2022" @default.
• W4296770176 type Work @default.
• W4296770176 citedByCount "1" @default.
• W4296770176 crossrefType "journal-article" @default.
• W4296770176 hasAuthorship W4296770176A5006065770 @default.
• W4296770176 hasAuthorship W4296770176A5017052469 @default.
• W4296770176 hasAuthorship W4296770176A5017859483 @default.
• W4296770176 hasAuthorship W4296770176A5019005078 @default.
• W4296770176 hasAuthorship W4296770176A5029484872 @default.
• W4296770176 hasAuthorship W4296770176A5041838620 @default.
• W4296770176 hasAuthorship W4296770176A5042548151 @default.
• W4296770176 hasAuthorship W4296770176A5052468413 @default.
• W4296770176 hasAuthorship W4296770176A5060291926 @default.
• W4296770176 hasAuthorship W4296770176A5073124436 @default.
• W4296770176 hasAuthorship W4296770176A5087929637 @default.
• W4296770176 hasAuthorship W4296770176A5088887574 @default.
• W4296770176 hasConcept C126322002 @default.
• W4296770176 hasConcept C134018914 @default.
• W4296770176 hasConcept C141359234 @default.
• W4296770176 hasConcept C151955695 @default.
• W4296770176 hasConcept C171089720 @default.
• W4296770176 hasConcept C2491326 @default.
• W4296770176 hasConcept C2776175234 @default.
• W4296770176 hasConcept C2780642333 @default.
• W4296770176 hasConcept C28859421 @default.
• W4296770176 hasConcept C511355011 @default.
• W4296770176 hasConcept C63645605 @default.
• W4296770176 hasConcept C71924100 @default.
• W4296770176 hasConcept C86803240 @default.
• W4296770176 hasConcept C95444343 @default.
• W4296770176 hasConceptScore W4296770176C126322002 @default.
• W4296770176 hasConceptScore W4296770176C134018914 @default.
• W4296770176 hasConceptScore W4296770176C141359234 @default.

• next