Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296773054> ?p ?o ?g. }
- W4296773054 endingPage "105791" @default.
- W4296773054 startingPage "105791" @default.
- W4296773054 abstract "This study investigated the antimicrobial and antibiofilm activity of KWI18, a new synthetic peptide. KWI18 was tested against planktonic cells and Pseudomonas aeruginosa and Candida parapsilosis biofilms. Time-kill and synergism assays were performed. Sorbitol, ergosterol, lipid peroxidation, and protein oxidation assays were used to gain insight into the mechanism of action of the peptide. Toxicity was evaluated against erythrocytes and Galleria mellonella. KWI18 showed antimicrobial activity, with minimum inhibitory concentration (MIC) values ranging from 0.5 to 10 μM. KWI18 at 10 × MIC reduced P. aeruginosa and C. parapsilosis biofilm formation and cell viability. Time-kill assays revealed that KWI18 inhibited the growth of P. aeruginosa in 4 h and that of C. parapsilosis in 6 h. The mechanism of action was related to ergosterol as well as induction of oxidative damage in cells and biofilms. Furthermore, KWI18 demonstrated low toxicity to erythrocytes and G. mellonella. KWI18 proved to be an effective antibiofilm agent, opening opportunities for the development of new antimicrobials." @default.
- W4296773054 created "2022-09-23" @default.
- W4296773054 creator A5016425590 @default.
- W4296773054 creator A5025622675 @default.
- W4296773054 creator A5039289153 @default.
- W4296773054 creator A5048114099 @default.
- W4296773054 creator A5053954992 @default.
- W4296773054 creator A5082297196 @default.
- W4296773054 date "2022-11-01" @default.
- W4296773054 modified "2023-10-04" @default.
- W4296773054 title "Prevention of hospital pathogen biofilm formation by antimicrobial peptide KWI18" @default.
- W4296773054 cites W1479789413 @default.
- W4296773054 cites W1494389875 @default.
- W4296773054 cites W1578742152 @default.
- W4296773054 cites W1779541940 @default.
- W4296773054 cites W1878373862 @default.
- W4296773054 cites W1884430856 @default.
- W4296773054 cites W1922101630 @default.
- W4296773054 cites W1970942356 @default.
- W4296773054 cites W1971642218 @default.
- W4296773054 cites W1990291110 @default.
- W4296773054 cites W1992192767 @default.
- W4296773054 cites W1999311978 @default.
- W4296773054 cites W2020799333 @default.
- W4296773054 cites W2024121327 @default.
- W4296773054 cites W2035152794 @default.
- W4296773054 cites W2045916983 @default.
- W4296773054 cites W2048054335 @default.
- W4296773054 cites W2050516505 @default.
- W4296773054 cites W2070574680 @default.
- W4296773054 cites W2076025899 @default.
- W4296773054 cites W2081359387 @default.
- W4296773054 cites W2084845164 @default.
- W4296773054 cites W2086368575 @default.
- W4296773054 cites W2124030991 @default.
- W4296773054 cites W2129723345 @default.
- W4296773054 cites W2144440398 @default.
- W4296773054 cites W2155201844 @default.
- W4296773054 cites W2157512355 @default.
- W4296773054 cites W2160780417 @default.
- W4296773054 cites W2163316049 @default.
- W4296773054 cites W2167896918 @default.
- W4296773054 cites W2169309331 @default.
- W4296773054 cites W2239430955 @default.
- W4296773054 cites W2239738725 @default.
- W4296773054 cites W2337957188 @default.
- W4296773054 cites W2356497820 @default.
- W4296773054 cites W2400575045 @default.
- W4296773054 cites W2507236629 @default.
- W4296773054 cites W2512702013 @default.
- W4296773054 cites W2556828189 @default.
- W4296773054 cites W2562261325 @default.
- W4296773054 cites W2567713795 @default.
- W4296773054 cites W2594090044 @default.
- W4296773054 cites W2601774570 @default.
- W4296773054 cites W2611615560 @default.
- W4296773054 cites W2626779258 @default.
- W4296773054 cites W2725083931 @default.
- W4296773054 cites W2742876372 @default.
- W4296773054 cites W2761783016 @default.
- W4296773054 cites W2767230632 @default.
- W4296773054 cites W2779985585 @default.
- W4296773054 cites W2780495254 @default.
- W4296773054 cites W2903234151 @default.
- W4296773054 cites W2905860627 @default.
- W4296773054 cites W2917735218 @default.
- W4296773054 cites W2934656438 @default.
- W4296773054 cites W2934966967 @default.
- W4296773054 cites W2936188727 @default.
- W4296773054 cites W2944679601 @default.
- W4296773054 cites W2946458716 @default.
- W4296773054 cites W2959707286 @default.
- W4296773054 cites W2983336787 @default.
- W4296773054 cites W2989651072 @default.
- W4296773054 cites W2991460964 @default.
- W4296773054 cites W2991592716 @default.
- W4296773054 cites W2994634742 @default.
- W4296773054 cites W2999664232 @default.
- W4296773054 cites W3013493164 @default.
- W4296773054 cites W3017609301 @default.
- W4296773054 cites W3039303197 @default.
- W4296773054 cites W3044519894 @default.
- W4296773054 cites W3047777575 @default.
- W4296773054 cites W3047966324 @default.
- W4296773054 cites W3083001420 @default.
- W4296773054 cites W3110914523 @default.
- W4296773054 cites W3134522229 @default.
- W4296773054 cites W3137585844 @default.
- W4296773054 cites W3156824858 @default.
- W4296773054 cites W3159592417 @default.
- W4296773054 cites W3164106853 @default.
- W4296773054 cites W3164122911 @default.
- W4296773054 cites W3164325402 @default.
- W4296773054 cites W3196245670 @default.
- W4296773054 cites W3200335034 @default.
- W4296773054 cites W4230690150 @default.
- W4296773054 cites W4293247451 @default.
- W4296773054 cites W950347584 @default.