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- W4296784691 endingPage "e1010122" @default.
- W4296784691 startingPage "e1010122" @default.
- W4296784691 abstract "Human RECQL4 is a member of the RecQ family of DNA helicases and functions during DNA replication and repair. RECQL4 mutations are associated with developmental defects and cancer. Although RECQL4 mutations lead to disease, RECQL4 overexpression is also observed in cancer, including breast and prostate. Thus, tight regulation of RECQL4 protein levels is crucial for genome stability. Because mammalian RECQL4 is essential, how cells regulate RECQL4 protein levels is largely unknown. Utilizing budding yeast, we investigated the RECQL4 homolog, HRQ1, during DNA crosslink repair. We find that Hrq1 functions in the error-free template switching pathway to mediate DNA intrastrand crosslink repair. Although Hrq1 mediates repair of cisplatin-induced lesions, it is paradoxically degraded by the proteasome following cisplatin treatment. By identifying the targeted lysine residues, we show that preventing Hrq1 degradation results in increased recombination and mutagenesis. Like yeast, human RECQL4 is similarly degraded upon exposure to crosslinking agents. Furthermore, over-expression of RECQL4 results in increased RAD51 foci, which is dependent on its helicase activity. Using bioinformatic analysis, we observe that RECQL4 overexpression correlates with increased recombination and mutations. Overall, our study uncovers a role for Hrq1/RECQL4 in DNA intrastrand crosslink repair and provides further insight how misregulation of RECQL4 can promote genomic instability, a cancer hallmark." @default.
- W4296784691 created "2022-09-23" @default.
- W4296784691 creator A5003648011 @default.
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- W4296784691 creator A5073085049 @default.
- W4296784691 date "2022-09-20" @default.
- W4296784691 modified "2023-10-07" @default.
- W4296784691 title "Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer" @default.
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- W4296784691 doi "https://doi.org/10.1371/journal.pgen.1010122" @default.
- W4296784691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36126066" @default.
- W4296784691 hasPublicationYear "2022" @default.
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