FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296792098> ?p ?o ?g. }

• W4296792098 endingPage "2281" @default.
• W4296792098 startingPage "2271" @default.
• W4296792098 abstract "To distinguish among predictors of seroconversion, progression to multiple autoantibodies and from multiple autoantibodies to type 1 diabetes in young children.Genetically high-risk newborns (n = 8,502) were followed for a median of 11.2 years (interquartile range 9.3-12.6); 835 (9.8%) developed islet autoantibodies and 283 (3.3%) were diagnosed with type 1 diabetes. Predictors were examined using Cox proportional hazards models.Predictors of seroconversion and progression differed, depending on the type of first appearing autoantibody. Male sex, Finnish residence, having a sibling with type 1 diabetes, the HLA DR4 allele, probiotic use before age 28 days, and single nucleotide polymorphism (SNP) rs689_A (INS) predicted seroconversion to IAA-first (having islet autoantibody to insulin as the first appearing autoantibody). Increased weight at 12 months and SNPs rs12708716_G (CLEC16A) and rs2292239_T (ERBB3) predicted GADA-first (autoantibody to GAD as the first appearing). For those having a father with type 1 diabetes, the SNPs rs2476601_A (PTPN22) and rs3184504_T (SH2B3) predicted both. Younger age at seroconversion predicted progression from single to multiple autoantibodies as well as progression to diabetes, except for those presenting with GADA-first. Family history of type 1 diabetes and the HLA DR4 allele predicted progression to multiple autoantibodies but not diabetes. Sex did not predict progression to multiple autoantibodies, but males progressed more slowly than females from multiple autoantibodies to diabetes. SKAP2 and MIR3681HG SNPs are newly reported to be significantly associated with progression from multiple autoantibodies to type 1 diabetes.Predictors of IAA-first versus GADA-first autoimmunity differ from each other and from the predictors of progression to diabetes." @default.
• W4296792098 created "2022-09-24" @default.
• W4296792098 creator A5001060251 @default.
• W4296792098 creator A5001132124 @default.
• W4296792098 creator A5001557307 @default.
• W4296792098 creator A5001640159 @default.
• W4296792098 creator A5001640598 @default.
• W4296792098 creator A5001739428 @default.
• W4296792098 creator A5001881311 @default.
• W4296792098 creator A5001909300 @default.
• W4296792098 creator A5002824850 @default.
• W4296792098 creator A5003107818 @default.
• W4296792098 creator A5003256895 @default.
• W4296792098 creator A5004105378 @default.
• W4296792098 creator A5004512339 @default.
• W4296792098 creator A5004621969 @default.
• W4296792098 creator A5004895861 @default.
• W4296792098 creator A5005156493 @default.
• W4296792098 creator A5005279462 @default.
• W4296792098 creator A5005786454 @default.
• W4296792098 creator A5005859687 @default.
• W4296792098 creator A5006033112 @default.
• W4296792098 creator A5006331676 @default.
• W4296792098 creator A5006499595 @default.
• W4296792098 creator A5006680848 @default.
• W4296792098 creator A5006967177 @default.
• W4296792098 creator A5007136885 @default.
• W4296792098 creator A5007219692 @default.
• W4296792098 creator A5007390241 @default.
• W4296792098 creator A5007639526 @default.
• W4296792098 creator A5007656583 @default.
• W4296792098 creator A5007853399 @default.
• W4296792098 creator A5008006023 @default.
• W4296792098 creator A5008573099 @default.
• W4296792098 creator A5008664061 @default.
• W4296792098 creator A5008841181 @default.
• W4296792098 creator A5009366716 @default.
• W4296792098 creator A5010083385 @default.
• W4296792098 creator A5010164573 @default.
• W4296792098 creator A5010428487 @default.
• W4296792098 creator A5010627733 @default.
• W4296792098 creator A5011722240 @default.
• W4296792098 creator A5011886992 @default.
• W4296792098 creator A5012112885 @default.
• W4296792098 creator A5012235494 @default.
• W4296792098 creator A5012604073 @default.
• W4296792098 creator A5012641612 @default.
• W4296792098 creator A5012783827 @default.
• W4296792098 creator A5013128015 @default.
• W4296792098 creator A5013309714 @default.
• W4296792098 creator A5013347012 @default.
• W4296792098 creator A5013682639 @default.
• W4296792098 creator A5013928770 @default.
• W4296792098 creator A5014208337 @default.
• W4296792098 creator A5014942240 @default.
• W4296792098 creator A5015148195 @default.
• W4296792098 creator A5015482136 @default.
• W4296792098 creator A5015649528 @default.
• W4296792098 creator A5016106030 @default.
• W4296792098 creator A5016359506 @default.
• W4296792098 creator A5016753010 @default.
• W4296792098 creator A5017006608 @default.
• W4296792098 creator A5017787850 @default.
• W4296792098 creator A5018123484 @default.
• W4296792098 creator A5018600726 @default.
• W4296792098 creator A5018807567 @default.
• W4296792098 creator A5019614984 @default.
• W4296792098 creator A5019661884 @default.
• W4296792098 creator A5019839364 @default.
• W4296792098 creator A5020362713 @default.
• W4296792098 creator A5021628160 @default.
• W4296792098 creator A5021822020 @default.
• W4296792098 creator A5021879937 @default.
• W4296792098 creator A5022260217 @default.
• W4296792098 creator A5022895698 @default.
• W4296792098 creator A5023070713 @default.
• W4296792098 creator A5023525758 @default.
• W4296792098 creator A5024635734 @default.
• W4296792098 creator A5025639170 @default.
• W4296792098 creator A5025837351 @default.
• W4296792098 creator A5025915235 @default.
• W4296792098 creator A5026404982 @default.
• W4296792098 creator A5026414381 @default.
• W4296792098 creator A5026620118 @default.
• W4296792098 creator A5026837875 @default.
• W4296792098 creator A5027375274 @default.
• W4296792098 creator A5027984154 @default.
• W4296792098 creator A5027997496 @default.
• W4296792098 creator A5028053766 @default.
• W4296792098 creator A5028735854 @default.
• W4296792098 creator A5029238451 @default.
• W4296792098 creator A5029311012 @default.
• W4296792098 creator A5029811295 @default.
• W4296792098 creator A5031075927 @default.
• W4296792098 creator A5031467310 @default.
• W4296792098 creator A5032156230 @default.
• W4296792098 creator A5032637491 @default.
• W4296792098 creator A5033949358 @default.

• next