Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296793955> ?p ?o ?g. }
- W4296793955 endingPage "5949" @default.
- W4296793955 startingPage "5949" @default.
- W4296793955 abstract "Aphids are one of the most damaging agricultural pests. For the sake of novel eco-friendly compounds with good activity for aphid control, a series of novel geranic acid esters containing substituted aromatic rings were designed by inverting ester groups of lead compounds. All compounds were characterized by HRMS, 1H-NMR, and 13C-NMR. In order to identify the effect of inversion ester groups on activity, a bioassay was conducted. The results showed that the repellent activity against Acyrthosiphon pisum (A. pisum) and the binding affinity with the odorant-binding protein 9 from A. pisum (ApisOBP9) of the compounds were increased after inversion of the ester groups. Particularly, 5f showed the best repellent activity (repellency proportion: 55.6%) and binding affinity (1/Ki: 0.49 µM). Meanwhile, the structure-activity relationships revealed that the introduction of meta-substitution of the benzene ring and halogen atoms, such as Cl and Br, facilitated the biological activity. The further molecular docking results demonstrated that hydrogen bonding interactions and hydrophobic interactions were vital for the binding affinity with ApisOBP9. Additionally, all compounds were predicted to be eco-friendly and their volatile physicochemical properties have been enhanced compared to the leads. The present results provide valuable clues for the further rational design of aphids' behavioral control agents." @default.
- W4296793955 created "2022-09-24" @default.
- W4296793955 creator A5004292559 @default.
- W4296793955 creator A5021293751 @default.
- W4296793955 creator A5028070258 @default.
- W4296793955 creator A5045448501 @default.
- W4296793955 creator A5048720972 @default.
- W4296793955 creator A5054784532 @default.
- W4296793955 creator A5074229634 @default.
- W4296793955 creator A5087777956 @default.
- W4296793955 creator A5091786703 @default.
- W4296793955 date "2022-09-13" @default.
- W4296793955 modified "2023-09-26" @default.
- W4296793955 title "Discovery of Novel Potential Aphid Repellents: Geranic Acid Esters Containing Substituted Aromatic Rings" @default.
- W4296793955 cites W139611266 @default.
- W4296793955 cites W1907817559 @default.
- W4296793955 cites W1919906216 @default.
- W4296793955 cites W1968934296 @default.
- W4296793955 cites W1978949517 @default.
- W4296793955 cites W1992909979 @default.
- W4296793955 cites W2014858249 @default.
- W4296793955 cites W2031372687 @default.
- W4296793955 cites W2047206590 @default.
- W4296793955 cites W2075186867 @default.
- W4296793955 cites W2085313140 @default.
- W4296793955 cites W2096125280 @default.
- W4296793955 cites W2114076611 @default.
- W4296793955 cites W2116961174 @default.
- W4296793955 cites W2127016153 @default.
- W4296793955 cites W2132406623 @default.
- W4296793955 cites W2161848147 @default.
- W4296793955 cites W2460204863 @default.
- W4296793955 cites W2520319948 @default.
- W4296793955 cites W2558700501 @default.
- W4296793955 cites W2591544722 @default.
- W4296793955 cites W2613545412 @default.
- W4296793955 cites W2724166124 @default.
- W4296793955 cites W2769853272 @default.
- W4296793955 cites W2791092652 @default.
- W4296793955 cites W2799886677 @default.
- W4296793955 cites W2801088198 @default.
- W4296793955 cites W2802197963 @default.
- W4296793955 cites W2972113081 @default.
- W4296793955 cites W2997234557 @default.
- W4296793955 cites W3005710086 @default.
- W4296793955 cites W3161553881 @default.
- W4296793955 cites W4283795820 @default.
- W4296793955 cites W2026125645 @default.
- W4296793955 doi "https://doi.org/10.3390/molecules27185949" @default.
- W4296793955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36144685" @default.
- W4296793955 hasPublicationYear "2022" @default.
- W4296793955 type Work @default.
- W4296793955 citedByCount "2" @default.
- W4296793955 countsByYear W42967939552023 @default.
- W4296793955 crossrefType "journal-article" @default.
- W4296793955 hasAuthorship W4296793955A5004292559 @default.
- W4296793955 hasAuthorship W4296793955A5021293751 @default.
- W4296793955 hasAuthorship W4296793955A5028070258 @default.
- W4296793955 hasAuthorship W4296793955A5045448501 @default.
- W4296793955 hasAuthorship W4296793955A5048720972 @default.
- W4296793955 hasAuthorship W4296793955A5054784532 @default.
- W4296793955 hasAuthorship W4296793955A5074229634 @default.
- W4296793955 hasAuthorship W4296793955A5087777956 @default.
- W4296793955 hasAuthorship W4296793955A5091786703 @default.
- W4296793955 hasBestOaLocation W42967939551 @default.
- W4296793955 hasConcept C103319777 @default.
- W4296793955 hasConcept C104488531 @default.
- W4296793955 hasConcept C116073593 @default.
- W4296793955 hasConcept C178790620 @default.
- W4296793955 hasConcept C185592680 @default.
- W4296793955 hasConcept C202751555 @default.
- W4296793955 hasConcept C22508944 @default.
- W4296793955 hasConcept C2775976403 @default.
- W4296793955 hasConcept C2776385806 @default.
- W4296793955 hasConcept C2776988988 @default.
- W4296793955 hasConcept C2777752112 @default.
- W4296793955 hasConcept C2779535332 @default.
- W4296793955 hasConcept C2781350953 @default.
- W4296793955 hasConcept C53105671 @default.
- W4296793955 hasConcept C54355233 @default.
- W4296793955 hasConcept C55493867 @default.
- W4296793955 hasConcept C59822182 @default.
- W4296793955 hasConcept C71240020 @default.
- W4296793955 hasConcept C86803240 @default.
- W4296793955 hasConceptScore W4296793955C103319777 @default.
- W4296793955 hasConceptScore W4296793955C104488531 @default.
- W4296793955 hasConceptScore W4296793955C116073593 @default.
- W4296793955 hasConceptScore W4296793955C178790620 @default.
- W4296793955 hasConceptScore W4296793955C185592680 @default.
- W4296793955 hasConceptScore W4296793955C202751555 @default.
- W4296793955 hasConceptScore W4296793955C22508944 @default.
- W4296793955 hasConceptScore W4296793955C2775976403 @default.
- W4296793955 hasConceptScore W4296793955C2776385806 @default.
- W4296793955 hasConceptScore W4296793955C2776988988 @default.
- W4296793955 hasConceptScore W4296793955C2777752112 @default.
- W4296793955 hasConceptScore W4296793955C2779535332 @default.
- W4296793955 hasConceptScore W4296793955C2781350953 @default.
- W4296793955 hasConceptScore W4296793955C53105671 @default.