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• W4296794334 endingPage "2420" @default.
• W4296794334 startingPage "2404" @default.
• W4296794334 abstract "Prenatal lead (Pb) exposure is associated with adverse developmental outcomes and to epigenetic alterations such as DNA methylation and hydroxymethylation in animal models and in newborn blood. Given the importance of the placenta in foetal development, we sought to examine how prenatal Pb exposure was associated with differential placental DNA methylation and hydroxymethylation and to identify affected biological pathways linked to developmental outcomes. Maternal (n = 167) and infant (n = 172) toenail and placenta (n = 115) samples for prenatal Pb exposure were obtained from participants in a US birth cohort, and methylation and hydroxymethylation data were quantified using the Illumina Infinium MethylationEPIC BeadChip. An epigenome-wide association study was applied to identify differential methylation and hydroxymethylation associated with Pb exposure. Biological functions of the Pb-associated genes were determined by overrepresentation analysis through ConsensusPathDB. Prenatal Pb quantified from maternal toenail, infant toenail, and placenta was associated with 480, 27, and 2 differentially methylated sites (q < 0.05), respectively, with both increases and decreases associated with exposure. Alternatively, we identified 2, 1, and 14 differentially hydroxymethylated site(s) associated with maternal toenail, infant toenail, and placental Pb, respectively, with most showing increases in hydroxymethylation with exposure. Significantly overrepresented pathways amongst genes associated with differential methylation and hydroxymethylation (q < 0.10) included mechanisms pertaining to nervous system and organ development, calcium transport and regulation, and signalling activities. Our results suggest that both methylation and hydroxymethylation in the placenta can be variable based on Pb exposure and that the pathways impacted could affect placental function." @default.
• W4296794334 created "2022-09-24" @default.
• W4296794334 creator A5012121180 @default.
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• W4296794334 creator A5087167358 @default.
• W4296794334 date "2022-09-23" @default.
• W4296794334 modified "2023-10-10" @default.
• W4296794334 title "Prenatal lead (Pb) exposure is associated with differential placental DNA methylation and hydroxymethylation in a human population" @default.
• W4296794334 cites W1165140024 @default.
• W4296794334 cites W1484220887 @default.
• W4296794334 cites W1883623951 @default.
• W4296794334 cites W1915485606 @default.
• W4296794334 cites W1966531228 @default.
• W4296794334 cites W1968799724 @default.
• W4296794334 cites W1970283692 @default.
• W4296794334 cites W1970547929 @default.
• W4296794334 cites W1975584335 @default.
• W4296794334 cites W1978631323 @default.
• W4296794334 cites W1981543052 @default.
• W4296794334 cites W1984236032 @default.
• W4296794334 cites W1988968873 @default.
• W4296794334 cites W1990542926 @default.
• W4296794334 cites W1997453048 @default.
• W4296794334 cites W1997678698 @default.
• W4296794334 cites W2005528054 @default.
• W4296794334 cites W2006977193 @default.
• W4296794334 cites W2009629707 @default.
• W4296794334 cites W2020740925 @default.
• W4296794334 cites W2022324453 @default.
• W4296794334 cites W2024613932 @default.
• W4296794334 cites W2026255880 @default.
• W4296794334 cites W2027034464 @default.
• W4296794334 cites W2031198121 @default.
• W4296794334 cites W2031977115 @default.
• W4296794334 cites W2032860166 @default.
• W4296794334 cites W2033945038 @default.
• W4296794334 cites W2041282581 @default.
• W4296794334 cites W2054085969 @default.
• W4296794334 cites W2056607606 @default.
• W4296794334 cites W2057472212 @default.
• W4296794334 cites W2059789942 @default.
• W4296794334 cites W2068918812 @default.
• W4296794334 cites W2071137557 @default.
• W4296794334 cites W2077066845 @default.
• W4296794334 cites W2079731478 @default.
• W4296794334 cites W2081182312 @default.
• W4296794334 cites W2088342479 @default.
• W4296794334 cites W2088501324 @default.
• W4296794334 cites W2091284879 @default.
• W4296794334 cites W2093240921 @default.
• W4296794334 cites W2097935950 @default.
• W4296794334 cites W2100825082 @default.
• W4296794334 cites W2101821193 @default.
• W4296794334 cites W2101870168 @default.
• W4296794334 cites W2107665951 @default.
• W4296794334 cites W2108664872 @default.
• W4296794334 cites W2110319588 @default.
• W4296794334 cites W2112674583 @default.
• W4296794334 cites W2119084006 @default.
• W4296794334 cites W2120477407 @default.
• W4296794334 cites W2120806558 @default.
• W4296794334 cites W2120876065 @default.
• W4296794334 cites W2123123442 @default.
• W4296794334 cites W2126489758 @default.
• W4296794334 cites W2127895812 @default.
• W4296794334 cites W2129958809 @default.
• W4296794334 cites W2131118500 @default.
• W4296794334 cites W2131336074 @default.
• W4296794334 cites W2134386050 @default.
• W4296794334 cites W2143240446 @default.
• W4296794334 cites W2146334297 @default.
• W4296794334 cites W2151014102 @default.
• W4296794334 cites W2151223134 @default.
• W4296794334 cites W2152636479 @default.
• W4296794334 cites W2157149147 @default.
• W4296794334 cites W2169353806 @default.
• W4296794334 cites W2180563484 @default.
• W4296794334 cites W2223191640 @default.
• W4296794334 cites W2225190625 @default.
• W4296794334 cites W2279993545 @default.
• W4296794334 cites W2309734139 @default.
• W4296794334 cites W2344467809 @default.
• W4296794334 cites W2347012456 @default.
• W4296794334 cites W2410931920 @default.
• W4296794334 cites W2514501238 @default.
• W4296794334 cites W2558053133 @default.
• W4296794334 cites W2567721002 @default.
• W4296794334 cites W2750633386 @default.
• W4296794334 cites W2757307583 @default.
• W4296794334 cites W2798233554 @default.
• W4296794334 cites W2898617795 @default.
• W4296794334 cites W2903042202 @default.
• W4296794334 cites W2909407563 @default.
• W4296794334 cites W2934806320 @default.
• W4296794334 cites W2966131964 @default.

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