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• W4296794856 endingPage "640" @default.
• W4296794856 startingPage "640" @default.
• W4296794856 abstract "Frequent detection of mycotoxins ochratoxin A (OTA) and citrinin (CIT) in ruminant feed and feedstuff can be a potential threat to feed safety, animal performance and health. Ineffective biodegradation of these mycotoxins by rumen microflora following ingestion of contaminated feeds can lead to their circulatory transport to tissues such as mammary gland as the result of their biodistribution throughout the body. The bovine mammary epithelium plays a pivotal role in maintaining milk yield and composition and contributes to innate immune defense of the udder. The present study is the first to investigate individual effects of OTA and CIT on barrier and innate immune functions of the bovine mammary epithelium using a bovine mammary epithelial cell line (MAC-T). Results indicated that OTA and CIT exposure for 48 h significantly decreased cell viability in a concentration-dependent manner (p < 0.05). A decrease in transepithelial electrical resistance and increase in paracellular flux of FITC-40 kDa dextran was significantly induced by OTA treatment (p < 0.05), but not by CIT after 48 h exposure. qPCR was performed for assessment of expression of tight-junction proteins, Toll-like receptor 4 (TLR4) and cytokines after 4, 24 and 48 h of exposure. Both OTA and CIT markedly downregulated expression of claudin 3 and occludin (p < 0.05), whereas CIT did not affect zonula occludens-1 expression. Expression of TLR4 was significantly upregulated by OTA (p < 0.001) but downregulated by CIT (p < 0.05) at 48 h. Expression of IL-6, TNF-a and TGF-β was significantly upregulated by OTA (p < 0.05), whereas IL-6 and TGF-β expression was downregulated by CIT (p < 0.01). These results suggest that OTA and CIT could potentially differentially modulate barrier and innate immune functions of mammary epithelium. The present study not only throws light on the individual toxicity of each mycotoxin on bovine mammary epithelium but also lays the foundation for future studies on the combined effects of the two mycotoxins." @default.
• W4296794856 created "2022-09-24" @default.
• W4296794856 creator A5000480555 @default.
• W4296794856 creator A5029771436 @default.
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• W4296794856 date "2022-09-16" @default.
• W4296794856 modified "2023-09-25" @default.
• W4296794856 title "Ochratoxin A and Citrinin Differentially Modulate Bovine Mammary Epithelial Cell Permeability and Innate Immune Function" @default.
• W4296794856 cites W148096308 @default.
• W4296794856 cites W1697181001 @default.
• W4296794856 cites W1964101969 @default.
• W4296794856 cites W1968740274 @default.
• W4296794856 cites W1971197093 @default.
• W4296794856 cites W1981140465 @default.
• W4296794856 cites W1986271436 @default.
• W4296794856 cites W1987265868 @default.
• W4296794856 cites W1997647138 @default.
• W4296794856 cites W2000285404 @default.
• W4296794856 cites W2002069093 @default.
• W4296794856 cites W2006501179 @default.
• W4296794856 cites W2006922083 @default.
• W4296794856 cites W2008081537 @default.
• W4296794856 cites W2017283353 @default.
• W4296794856 cites W2018422534 @default.
• W4296794856 cites W2021107465 @default.
• W4296794856 cites W2021763936 @default.
• W4296794856 cites W2022615654 @default.
• W4296794856 cites W2028943470 @default.
• W4296794856 cites W2035725799 @default.
• W4296794856 cites W2052503497 @default.
• W4296794856 cites W2058539845 @default.
• W4296794856 cites W2090675135 @default.
• W4296794856 cites W2105818869 @default.
• W4296794856 cites W2107277218 @default.
• W4296794856 cites W2113842526 @default.
• W4296794856 cites W2117979757 @default.
• W4296794856 cites W2128882073 @default.
• W4296794856 cites W2132822330 @default.
• W4296794856 cites W2137146500 @default.
• W4296794856 cites W2146438991 @default.
• W4296794856 cites W2154612703 @default.
• W4296794856 cites W2162400295 @default.
• W4296794856 cites W2169186082 @default.
• W4296794856 cites W2192080449 @default.
• W4296794856 cites W2199587937 @default.
• W4296794856 cites W2206441267 @default.
• W4296794856 cites W2284092633 @default.
• W4296794856 cites W2291480286 @default.
• W4296794856 cites W2320904587 @default.
• W4296794856 cites W2325481086 @default.
• W4296794856 cites W2328119989 @default.
• W4296794856 cites W2335786924 @default.
• W4296794856 cites W2401013275 @default.
• W4296794856 cites W2551170256 @default.
• W4296794856 cites W2567794902 @default.
• W4296794856 cites W2581332781 @default.
• W4296794856 cites W2585398849 @default.
• W4296794856 cites W2603277017 @default.
• W4296794856 cites W2616119446 @default.
• W4296794856 cites W2625403026 @default.
• W4296794856 cites W2749648053 @default.
• W4296794856 cites W2766995643 @default.
• W4296794856 cites W2768793637 @default.
• W4296794856 cites W2769085246 @default.
• W4296794856 cites W2772535512 @default.
• W4296794856 cites W2776943472 @default.
• W4296794856 cites W2790219279 @default.
• W4296794856 cites W2795247795 @default.
• W4296794856 cites W2797955106 @default.
• W4296794856 cites W2802207531 @default.
• W4296794856 cites W2802264226 @default.
• W4296794856 cites W2808824486 @default.
• W4296794856 cites W2810147622 @default.
• W4296794856 cites W2884635124 @default.
• W4296794856 cites W2885534843 @default.
• W4296794856 cites W2894805676 @default.
• W4296794856 cites W2896940132 @default.
• W4296794856 cites W2897927120 @default.
• W4296794856 cites W2899851803 @default.
• W4296794856 cites W2902736161 @default.
• W4296794856 cites W2904779067 @default.
• W4296794856 cites W2904918763 @default.
• W4296794856 cites W2906395590 @default.
• W4296794856 cites W2909462630 @default.
• W4296794856 cites W2941874449 @default.
• W4296794856 cites W2947702218 @default.
• W4296794856 cites W2950064447 @default.
• W4296794856 cites W2955985518 @default.
• W4296794856 cites W2956078079 @default.
• W4296794856 cites W2965186594 @default.
• W4296794856 cites W2978098693 @default.
• W4296794856 cites W2979703095 @default.
• W4296794856 cites W2981941745 @default.
• W4296794856 cites W2991480638 @default.
• W4296794856 cites W2991876991 @default.
• W4296794856 cites W3004919192 @default.
• W4296794856 cites W3007283026 @default.

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