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• W4296802426 abstract "Twenty new malabaricane triterpenoids, astramalabaricosides A-T (1-20), were isolated from the roots of Astragalus membranaceus var. mongholicus (Astragali Radix). Their structures were determined by spectroscopic analysis, and the use of the circular dichroism exciton chirality method, quantum chemical calculations, and chemical methods. Malabaricane triterpenoids, an unusual group with the 6-6-5-tricyclic core, are distributed in plants (e.g., Simaroubaceae, Polypodiaceae, and Fabaceae), a marine sponge, and fungi, and their number obtained to date is limited. Compounds 1-20 were characterized as glycosides with a highly oxygenated side chain, and 13-20 were the first cyclic carbonate derivatives among the malabaricane triterpenoids. The stereocluster formed from the continuous hydroxylated chiral carbons in each highly oxygenated side chain and the 6-6-5-tricyclic core system were entirely segregated, and the independent identification of their stereoconfigurations required considerable effort. The migratory inhibitory and antiproliferative activities of 1-20 were evaluated by wound-healing and cell-viability assays, respectively. Most compounds showed significant migratory inhibitory activity, and a preliminary structure-activity relationship was developed. Malabaricane triterpenoids are being reported in the genus Astragalus for the first time." @default.
• W4296802426 created "2022-09-24" @default.
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• W4296802426 date "2022-09-22" @default.
• W4296802426 modified "2023-10-15" @default.
• W4296802426 title "Astramalabaricosides A–T, Highly Oxygenated Malabaricane Triterpenoids with Migratory Inhibitory Activity from <i>Astragalus membranaceus</i> var. <i>mongholicus</i>" @default.
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• W4296802426 doi "https://doi.org/10.1021/acs.jnatprod.2c00494" @default.
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