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- W4296806005 endingPage "1975" @default.
- W4296806005 startingPage "1975" @default.
- W4296806005 abstract "This study aimed to develop and evaluate thermoresponsive in situ microgels for the local ocular delivery of prednisolone (PRD) (PRD microgels) to improve drug bioavailability and prolong ocular drug residence time. Lipid nanosystems of PRD microemulsions (PRD-MEs) were prepared and evaluated at a drug concentration of 0.25-0.75%. PRD microgels were prepared by incorporating PRD-MEs into 10 and 12% Pluronic® F127 (F127) or combinations of 12% F127 and 1-10% Kolliphor®P188 (F68). PRD microgels were characterized for physicochemical, rheological, and mucoadhesive properties, eye irritation, and stability. Results showed that PRD-MEs were clear, miscible, thermodynamically stable, and spherical with droplet size (16.4 ± 2.2 nm), polydispersity index (0.24 ± 0.01), and zeta potential (-21.03 ± 1.24 mV). The PRD microgels were clear with pH (5.37-5.81), surface tension (30.96-38.90 mN/m), size, and zeta potential of mixed polymeric micelles (20.1-23.9 nm and -1.34 to -10.25 mV, respectively), phase transition temperature (25.3-36 °C), and gelation time (1.44-2.47 min). The FTIR spectra revealed chemical compatibility between PRD and microgel components. PRD microgels showed pseudoplastic flow, viscoelastic and mucoadhesive properties, absence of eye irritation, and drug content (99.3 to 106.3%) with a sustained drug release for 16-24 h. Microgels were physicochemically and rheologically stable for three to six months. Therefore, PRD microgels possess potential vehicles for local ocular delivery." @default.
- W4296806005 created "2022-09-24" @default.
- W4296806005 creator A5001723906 @default.
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- W4296806005 creator A5073338828 @default.
- W4296806005 creator A5081169550 @default.
- W4296806005 creator A5089546426 @default.
- W4296806005 date "2022-09-19" @default.
- W4296806005 modified "2023-10-14" @default.
- W4296806005 title "Microemulsions as Lipid Nanosystems Loaded into Thermoresponsive In Situ Microgels for Local Ocular Delivery of Prednisolone" @default.
- W4296806005 cites W10332664 @default.
- W4296806005 cites W1541621631 @default.
- W4296806005 cites W1741982559 @default.
- W4296806005 cites W1963490806 @default.
- W4296806005 cites W1966341577 @default.
- W4296806005 cites W1967267374 @default.
- W4296806005 cites W1969373623 @default.
- W4296806005 cites W1975717121 @default.
- W4296806005 cites W1975759164 @default.
- W4296806005 cites W1977072597 @default.
- W4296806005 cites W1979276920 @default.
- W4296806005 cites W1987992156 @default.
- W4296806005 cites W1988413525 @default.
- W4296806005 cites W1991968794 @default.
- W4296806005 cites W1995984386 @default.
- W4296806005 cites W1996262004 @default.
- W4296806005 cites W2004172549 @default.
- W4296806005 cites W2009282459 @default.
- W4296806005 cites W2009451101 @default.
- W4296806005 cites W2012245891 @default.
- W4296806005 cites W2021524051 @default.
- W4296806005 cites W2023249776 @default.
- W4296806005 cites W2026940257 @default.
- W4296806005 cites W2028868419 @default.
- W4296806005 cites W2029408225 @default.
- W4296806005 cites W2035492275 @default.
- W4296806005 cites W2036700491 @default.
- W4296806005 cites W2042219297 @default.
- W4296806005 cites W2047019406 @default.
- W4296806005 cites W2051624682 @default.
- W4296806005 cites W2055268089 @default.
- W4296806005 cites W2058848634 @default.
- W4296806005 cites W2064887945 @default.
- W4296806005 cites W2069499038 @default.
- W4296806005 cites W2072608237 @default.
- W4296806005 cites W2074417814 @default.
- W4296806005 cites W2076621865 @default.
- W4296806005 cites W2086062588 @default.
- W4296806005 cites W2089423143 @default.
- W4296806005 cites W2092361616 @default.
- W4296806005 cites W2129509912 @default.
- W4296806005 cites W2144780027 @default.
- W4296806005 cites W2156483611 @default.
- W4296806005 cites W2159813840 @default.
- W4296806005 cites W2163597049 @default.
- W4296806005 cites W2165168239 @default.
- W4296806005 cites W2295839376 @default.
- W4296806005 cites W2554296198 @default.
- W4296806005 cites W2587308098 @default.
- W4296806005 cites W2601493146 @default.
- W4296806005 cites W2605966271 @default.
- W4296806005 cites W2613052595 @default.
- W4296806005 cites W2734723409 @default.
- W4296806005 cites W2767671905 @default.
- W4296806005 cites W2791362637 @default.
- W4296806005 cites W2792122318 @default.
- W4296806005 cites W2799585803 @default.
- W4296806005 cites W2803898745 @default.
- W4296806005 cites W287840921 @default.
- W4296806005 cites W2914817934 @default.
- W4296806005 cites W2944258371 @default.
- W4296806005 cites W2947904839 @default.
- W4296806005 cites W2955620780 @default.
- W4296806005 cites W2971451226 @default.
- W4296806005 cites W2989382082 @default.
- W4296806005 cites W2995362809 @default.
- W4296806005 cites W2999564629 @default.
- W4296806005 cites W2999755547 @default.
- W4296806005 cites W3008673236 @default.
- W4296806005 cites W3023062687 @default.
- W4296806005 cites W3023921650 @default.
- W4296806005 cites W3032541602 @default.
- W4296806005 cites W3037166805 @default.
- W4296806005 cites W3042180409 @default.
- W4296806005 cites W3084234654 @default.
- W4296806005 cites W3084429358 @default.
- W4296806005 cites W3092834112 @default.
- W4296806005 cites W3111286734 @default.
- W4296806005 cites W3130816984 @default.
- W4296806005 cites W3180373357 @default.
- W4296806005 cites W3195951839 @default.
- W4296806005 cites W3200660792 @default.
- W4296806005 cites W3214550567 @default.
- W4296806005 cites W4200139149 @default.
- W4296806005 cites W4207010050 @default.
- W4296806005 cites W4213243714 @default.