FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296807788> ?p ?o ?g. }

• W4296807788 endingPage "3775" @default.
• W4296807788 startingPage "3775" @default.
• W4296807788 abstract "The increasing prevalence of obesity and type 2 diabetes (T2DM) is provoking an important socioeconomic burden mainly in the form of cardiovascular disease (CVD). One successful strategy is the so-called metabolic surgery whose beneficial effects are beyond dietary restrictions and weight loss. One key underlying mechanism behind this surgery is the cooperative improved action of the preproglucagon-derived hormones, glucagon, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) which exert their functions through G protein-coupled receptors (GPCR). Great success has been reached with therapies based on the GLP-1 receptor monoagonism; therefore, a logical and rational approach is the use of the dual and triagonism of GCPC to achieve complete metabolic homeostasis. The present review describes novel findings regarding the complex biology of the preproglucagon-derived hormones, their signaling, and the drug development of their analogues, especially those acting as dual and triagonists. Moreover, the main investigations into animal models and ongoing clinical trials using these unimolecular dual and triagonists are included which have demonstrated their safety, efficacy, and beneficial effects on the CV system. These therapeutic strategies could greatly impact the treatment of CVD with unprecedented benefits which will be revealed in the next years." @default.
• W4296807788 created "2022-09-24" @default.
• W4296807788 creator A5001845805 @default.
• W4296807788 creator A5013131609 @default.
• W4296807788 creator A5032349304 @default.
• W4296807788 creator A5070107898 @default.
• W4296807788 creator A5073736448 @default.
• W4296807788 date "2022-09-13" @default.
• W4296807788 modified "2023-10-03" @default.
• W4296807788 title "Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone Peptide-Derived G Protein Coupled Receptor Agonists" @default.
• W4296807788 cites W1592686897 @default.
• W4296807788 cites W1887007488 @default.
• W4296807788 cites W1969932276 @default.
• W4296807788 cites W1984664578 @default.
• W4296807788 cites W2004456679 @default.
• W4296807788 cites W2004753626 @default.
• W4296807788 cites W2009131397 @default.
• W4296807788 cites W2028502361 @default.
• W4296807788 cites W2047944726 @default.
• W4296807788 cites W2072686461 @default.
• W4296807788 cites W2075567076 @default.
• W4296807788 cites W2080103614 @default.
• W4296807788 cites W2084948079 @default.
• W4296807788 cites W2094758439 @default.
• W4296807788 cites W2097433877 @default.
• W4296807788 cites W2099475256 @default.
• W4296807788 cites W2129033842 @default.
• W4296807788 cites W2129983555 @default.
• W4296807788 cites W2141499934 @default.
• W4296807788 cites W2149717292 @default.
• W4296807788 cites W2154497567 @default.
• W4296807788 cites W2162140339 @default.
• W4296807788 cites W2279717914 @default.
• W4296807788 cites W2340191301 @default.
• W4296807788 cites W2464238397 @default.
• W4296807788 cites W2471889258 @default.
• W4296807788 cites W2484036040 @default.
• W4296807788 cites W2593571692 @default.
• W4296807788 cites W2598447407 @default.
• W4296807788 cites W2608961189 @default.
• W4296807788 cites W2622944243 @default.
• W4296807788 cites W2624032915 @default.
• W4296807788 cites W2738105512 @default.
• W4296807788 cites W2738712721 @default.
• W4296807788 cites W2741958922 @default.
• W4296807788 cites W2768555410 @default.
• W4296807788 cites W2788969344 @default.
• W4296807788 cites W2790574529 @default.
• W4296807788 cites W2795481136 @default.
• W4296807788 cites W2804558913 @default.
• W4296807788 cites W2808030638 @default.
• W4296807788 cites W2808958607 @default.
• W4296807788 cites W2808959426 @default.
• W4296807788 cites W2809236699 @default.
• W4296807788 cites W2810819338 @default.
• W4296807788 cites W2886277721 @default.
• W4296807788 cites W2895135221 @default.
• W4296807788 cites W2895666357 @default.
• W4296807788 cites W2899885364 @default.
• W4296807788 cites W2901306081 @default.
• W4296807788 cites W2901979245 @default.
• W4296807788 cites W2902410297 @default.
• W4296807788 cites W2904780076 @default.
• W4296807788 cites W2920248606 @default.
• W4296807788 cites W2941039646 @default.
• W4296807788 cites W2947957797 @default.
• W4296807788 cites W2948394616 @default.
• W4296807788 cites W2955108563 @default.
• W4296807788 cites W2955219150 @default.
• W4296807788 cites W2965067097 @default.
• W4296807788 cites W2965725909 @default.
• W4296807788 cites W2968073288 @default.
• W4296807788 cites W2978840913 @default.
• W4296807788 cites W2987382375 @default.
• W4296807788 cites W2990541661 @default.
• W4296807788 cites W2990930253 @default.
• W4296807788 cites W2991016692 @default.
• W4296807788 cites W3006226784 @default.
• W4296807788 cites W3008317004 @default.
• W4296807788 cites W3010741823 @default.
• W4296807788 cites W3027852565 @default.
• W4296807788 cites W3038975816 @default.
• W4296807788 cites W3046891294 @default.
• W4296807788 cites W3081515235 @default.
• W4296807788 cites W3090919864 @default.
• W4296807788 cites W3091457409 @default.
• W4296807788 cites W3092613060 @default.
• W4296807788 cites W3110873848 @default.
• W4296807788 cites W3111709040 @default.
• W4296807788 cites W3118758885 @default.
• W4296807788 cites W3121704649 @default.
• W4296807788 cites W3127462604 @default.
• W4296807788 cites W3134075201 @default.
• W4296807788 cites W3134100899 @default.
• W4296807788 cites W3135377013 @default.
• W4296807788 cites W3144177610 @default.
• W4296807788 cites W3160773731 @default.
• W4296807788 cites W3161292733 @default.

• next