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- W4296817698 abstract "Human fetal membrane mesenchymal stromal cells (hFM-MSCs) are a cell population easily isolable from the amniochorionic membrane of term placentas, without ethical issues or safety limitations. We previously reported that hFM-MSCs share some epigenetic characteristics with pluripotent stem cells and can overcome the mesenchymal commitment. Here, we demonstrated that hFM-MSCs can give rise to spinal motor neurons by the sequential exposure to specific factors that induced a neuralization, caudalization and ventralization of undifferentiated cells, leading to a gradual gene and protein upregulation of early and late MN markers. Also, spontaneous electrical activity (spikes and bursts) was recorded. Finally, when co-cultured with myotubes, differentiated MNs were able to create functional neuromuscular junctions that induced robust skeletal muscle cell contractions. These data demonstrated the hFM-MSCs can generate a mature and functional MN population that may represent an alternative source for regenerative medicine, disease modeling or drug screening." @default.
- W4296817698 created "2022-09-24" @default.
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- W4296817698 date "2022-10-01" @default.
- W4296817698 modified "2023-09-26" @default.
- W4296817698 title "Human fetal membrane-mesenchymal stromal cells generate functional spinal motor neurons in vitro" @default.
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- W4296817698 doi "https://doi.org/10.1016/j.isci.2022.105197" @default.
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- W4296817698 hasPublicationYear "2022" @default.
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