FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296818742> ?p ?o ?g. }

• W4296818742 endingPage "105200" @default.
• W4296818742 startingPage "105200" @default.
• W4296818742 abstract "The United States Environmental Protection Agency (EPA) has been pursuing new high throughput in vitro assays to characterize endocrine disrupting chemicals (EDCs) that interact with estrogen receptor signaling. We characterize two new PRL-HeLa cell models expressing either inducible C-terminal (iGFP-ER) or N-terminal (iER-GFP) tagged estrogen receptor-α (ERα) that allows direct visualization of chromatin binding. These models are an order of magnitude more sensitive, detecting 87 - 93% of very weak estrogens tested compared to only 27% by a previous PRL-HeLa variant and compares favorably to the 73% detected by an EPA-developed computational model using in vitro data. Importantly, the chromatin binding assays distinguished agonist- and antagonist-like phenotypes without activity specific assays. Finally, analysis of complex environmentally relevant chemical mixtures demonstrated how chromatin binding data can be used in risk assessment models to predict activity. These new assays should be a useful in vitro tool to screen for estrogenic activity." @default.
• W4296818742 created "2022-09-24" @default.
• W4296818742 creator A5015613726 @default.
• W4296818742 creator A5026736259 @default.
• W4296818742 creator A5067467801 @default.
• W4296818742 creator A5070135589 @default.
• W4296818742 date "2022-10-01" @default.
• W4296818742 modified "2023-09-30" @default.
• W4296818742 title "Sensitive image-based chromatin binding assays using inducible ERα to rapidly characterize estrogenic chemicals and mixtures" @default.
• W4296818742 cites W1789164482 @default.
• W4296818742 cites W1835137027 @default.
• W4296818742 cites W1979801990 @default.
• W4296818742 cites W1993210636 @default.
• W4296818742 cites W2016413285 @default.
• W4296818742 cites W2030718808 @default.
• W4296818742 cites W2040630181 @default.
• W4296818742 cites W2051656824 @default.
• W4296818742 cites W2062244421 @default.
• W4296818742 cites W2074151102 @default.
• W4296818742 cites W2076607897 @default.
• W4296818742 cites W2088832076 @default.
• W4296818742 cites W2109728079 @default.
• W4296818742 cites W2117089877 @default.
• W4296818742 cites W2140321480 @default.
• W4296818742 cites W2168525852 @default.
• W4296818742 cites W2171903133 @default.
• W4296818742 cites W2282228400 @default.
• W4296818742 cites W2296849581 @default.
• W4296818742 cites W2315587854 @default.
• W4296818742 cites W2415893412 @default.
• W4296818742 cites W2429101022 @default.
• W4296818742 cites W2528897263 @default.
• W4296818742 cites W2587870279 @default.
• W4296818742 cites W2734980640 @default.
• W4296818742 cites W2763198880 @default.
• W4296818742 cites W2808538861 @default.
• W4296818742 cites W2884716689 @default.
• W4296818742 cites W2999120350 @default.
• W4296818742 cites W3023395636 @default.
• W4296818742 cites W3033388808 @default.
• W4296818742 cites W3087945846 @default.
• W4296818742 cites W3118911627 @default.
• W4296818742 cites W3202643597 @default.
• W4296818742 cites W4226079108 @default.
• W4296818742 cites W4252231837 @default.
• W4296818742 doi "https://doi.org/10.1016/j.isci.2022.105200" @default.
• W4296818742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36238893" @default.
• W4296818742 hasPublicationYear "2022" @default.
• W4296818742 type Work @default.
• W4296818742 citedByCount "0" @default.
• W4296818742 crossrefType "journal-article" @default.
• W4296818742 hasAuthorship W4296818742A5015613726 @default.
• W4296818742 hasAuthorship W4296818742A5026736259 @default.
• W4296818742 hasAuthorship W4296818742A5067467801 @default.
• W4296818742 hasAuthorship W4296818742A5070135589 @default.
• W4296818742 hasBestOaLocation W42968187421 @default.
• W4296818742 hasConcept C121608353 @default.
• W4296818742 hasConcept C172313692 @default.
• W4296818742 hasConcept C185592680 @default.
• W4296818742 hasConcept C202751555 @default.
• W4296818742 hasConcept C2777164284 @default.
• W4296818742 hasConcept C2777366897 @default.
• W4296818742 hasConcept C33618052 @default.
• W4296818742 hasConcept C530470458 @default.
• W4296818742 hasConcept C54355233 @default.
• W4296818742 hasConcept C552990157 @default.
• W4296818742 hasConcept C55493867 @default.
• W4296818742 hasConcept C70721500 @default.
• W4296818742 hasConcept C83640560 @default.
• W4296818742 hasConcept C84606932 @default.
• W4296818742 hasConcept C86803240 @default.
• W4296818742 hasConcept C95444343 @default.
• W4296818742 hasConceptScore W4296818742C121608353 @default.
• W4296818742 hasConceptScore W4296818742C172313692 @default.
• W4296818742 hasConceptScore W4296818742C185592680 @default.
• W4296818742 hasConceptScore W4296818742C202751555 @default.
• W4296818742 hasConceptScore W4296818742C2777164284 @default.
• W4296818742 hasConceptScore W4296818742C2777366897 @default.
• W4296818742 hasConceptScore W4296818742C33618052 @default.
• W4296818742 hasConceptScore W4296818742C530470458 @default.
• W4296818742 hasConceptScore W4296818742C54355233 @default.
• W4296818742 hasConceptScore W4296818742C552990157 @default.
• W4296818742 hasConceptScore W4296818742C55493867 @default.
• W4296818742 hasConceptScore W4296818742C70721500 @default.
• W4296818742 hasConceptScore W4296818742C83640560 @default.
• W4296818742 hasConceptScore W4296818742C84606932 @default.
• W4296818742 hasConceptScore W4296818742C86803240 @default.
• W4296818742 hasConceptScore W4296818742C95444343 @default.
• W4296818742 hasIssue "10" @default.
• W4296818742 hasLocation W42968187421 @default.
• W4296818742 hasLocation W42968187422 @default.
• W4296818742 hasLocation W42968187423 @default.
• W4296818742 hasLocation W42968187424 @default.
• W4296818742 hasOpenAccess W4296818742 @default.
• W4296818742 hasPrimaryLocation W42968187421 @default.
• W4296818742 hasRelatedWork W2005831605 @default.
• W4296818742 hasRelatedWork W200925908 @default.
• W4296818742 hasRelatedWork W2015949605 @default.

• next